Ecm10p

Summary

Gene Symbol: Ecm10p
Description: Hsp70 family ATPase ECM10
Alias: SSC3, Hsp70 family ATPase ECM10
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Sakasegawa Y, Hachiya N, Tsukita S, Kaneko K. Ecm10p localizes in yeast mitochondrial nucleoids and its overexpression induces extensive mitochondrial DNA aggregations. Biochem Biophys Res Commun. 2003;309:217-21 pubmed
    b>Ecm10p was initially identified as a cell wall synthesis-related gene product [Genetics 147 (1997) 435] and also reported as a mitochondrial protein which was partially capable of compensating the phenotypic defect by SSC1 gene mutation [..
  2. Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W, Hell K. ATPase domain and interdomain linker play a key role in aggregation of mitochondrial Hsp70 chaperone Ssc1. J Biol Chem. 2010;285:4423-31 pubmed publisher
    ..In conclusion, our results suggest that interdomain communication makes Ssc1 prone to aggregation. Hep1 counteracts aggregation by binding to this aggregation-prone conformer. ..
  3. Baumann F, Milisav I, Neupert W, Herrmann J. Ecm10, a novel hsp70 homolog in the mitochondrial matrix of the yeast Saccharomyces cerevisiae. FEBS Lett. 2000;487:307-12 pubmed
    ..Deletion of ecm10 leads to synthetic growth defects with ssc1 mutations at low temperature. Our data suggest an overlapping function of Ecm10 and Ssc1. ..
  4. Pareek G, Samaddar M, D Silva P. Primary sequence that determines the functional overlap between mitochondrial heat shock protein 70 Ssc1 and Ssc3 of Saccharomyces cerevisiae. J Biol Chem. 2011;286:19001-13 pubmed publisher
    ..at the biochemical level between mitochondrial heat shock protein 70 (mtHsp70) Ssc1 and an uncharacterized Ssc3 paralog...