Gene Symbol: DRE2
Description: electron carrier DRE2
Alias: electron carrier DRE2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Vernis L, Facca C, Delagoutte E, Soler N, Chanet R, Guiard B, et al. A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast. PLoS ONE. 2009;4:e4376 pubmed publisher
    ..b>Dre2, an essential Fe/S cluster protein and homologue of human anti-apoptotic Ciapin1, was identified as a molecular ..
  2. Netz D, Stümpfig M, Dore C, Muhlenhoff U, Pierik A, Lill R. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010;6:758-65 pubmed publisher
    ..and show by cell biological, biochemical and spectroscopic approaches that the complex of Tah18 and the CIA protein Dre2 is part of an electron transfer chain functioning in an early step of cytosolic Fe-S protein biogenesis...
  3. Chanet R, Heude M. Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet. 2003;43:337-50 pubmed
    ..Finally, mutations in three genes of unknown function were isolated (NBP35, DRE2, TAH18)...
  4. Soler N, Delagoutte E, Miron S, Facca C, Baïlle D, D Autréaux B, et al. Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability. Mol Microbiol. 2011;82:54-67 pubmed publisher
    Tah18-Dre2 is a recently identified yeast protein complex, which is highly conserved in human and has been implicated in the regulation of oxidative stress induced cell death and in cytosolic Fe-S proteins synthesis...
  5. Zhang Y, Lyver E, Nakamaru Ogiso E, Yoon H, Amutha B, Lee D, et al. Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis. Mol Cell Biol. 2008;28:5569-82 pubmed publisher
    ..with mitochondrial iron carrier proteins in Saccharomyces cerevisiae, a hypomorphic mutation of the essential DRE2 gene was found to confer lethality when combined with Delta mrs3 and Delta mrs4...
  6. Zhang Y, Liu L, Wu X, An X, Stubbe J, Huang M. Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins. J Biol Chem. 2011;286:41499-509 pubmed publisher
    ..a pathway that is likely dependent on the cytosolic monothiol glutaredoxins Grx3/Grx4 and the Fe-S cluster protein Dre2. rnr4 mutants are defective in iron loading into nascent ? and are hypersensitive to iron depletion and the Tyr(•)..
  7. Zhang Y, Yang C, Dancis A, Nakamaru Ogiso E. EPR studies of wild type and mutant Dre2 identify essential [2Fe--2S] and [4Fe--4S] clusters and their cysteine ligands. J Biochem. 2017;161:67-78 pubmed publisher
    Yeast Dre2 (anamorsin or CIAPIN1) is an essential component for cytosolic Fe/S cluster biosynthesis...
  8. Mirzaei H, Rogers R, Grimes B, Eng J, Aderem A, Aebersold R. Characterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometry. Mol Biosyst. 2010;6:2004-14 pubmed publisher
    ..cerevisiae. We then applied the method to detect toxin induced changes in the poly-ubiquitination profile in complex and enriched protein samples. ..
  9. Soler N, Craescu C, Gallay J, Frapart Y, Mansuy D, Raynal B, et al. A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2. FEBS J. 2012;279:2108-19 pubmed publisher
    Yeast Dre2 is an essential Fe-S cluster-containing protein that has been implicated in cytosolic Fe-S protein biogenesis and in cell death regulation in response to oxidative stress...

More Information


  1. Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, et al. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A. 2014;111:E1695-704 pubmed publisher
    ..Here, we demonstrate that the conserved Fe-S protein-diflavin reductase complex, Dre2-Tah18, plays a critical role in RNR cofactor biosynthesis...
  2. Yoshikawa Y, Nasuno R, Kawahara N, Nishimura A, Watanabe D, Takagi H. Regulatory mechanism of the flavoprotein Tah18-dependent nitric oxide synthesis and cell death in yeast. Nitric Oxide. 2016;57:85-91 pubmed publisher
    ..that the flavoprotein Tah18, which was previously shown to transfer electrons to the iron-sulfur cluster protein Dre2, is involved in NOS-like activity in the yeast Saccharomyces cerevisiae...
  3. Netz D, Genau H, Weiler B, Bill E, Pierik A, Lill R. The conserved protein Dre2 uses essential [2Fe-2S] and [4Fe-4S] clusters for its function in cytosolic iron-sulfur protein assembly. Biochem J. 2016;473:2073-85 pubmed publisher
    ..Maturation is initiated by the electron transfer chain NADPH-diflavin reductase Tah18-Fe-S protein Dre2 that facilitates the de novo assembly of a [4Fe-4S] cluster on the scaffold complex Cfd1-Nbp35...
  4. Li H, Stümpfig M, Zhang C, An X, Stubbe J, Lill R, et al. The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. J Biol Chem. 2017;292:11445-11451 pubmed publisher
    ..2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for ..