Genomes and Genes
Gene Symbol: DRE2
Description: electron carrier DRE2
Alias: electron carrier DRE2
Species: Saccharomyces cerevisiae S288c
- Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, et al. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A. 2014;111:E1695-704 pubmed publisher..Here, we demonstrate that the conserved Fe-S protein-diflavin reductase complex, Dre2-Tah18, plays a critical role in RNR cofactor biosynthesis...
- Yoshikawa Y, Nasuno R, Kawahara N, Nishimura A, Watanabe D, Takagi H. Regulatory mechanism of the flavoprotein Tah18-dependent nitric oxide synthesis and cell death in yeast. Nitric Oxide. 2016;57:85-91 pubmed publisher..that the flavoprotein Tah18, which was previously shown to transfer electrons to the iron-sulfur cluster protein Dre2, is involved in NOS-like activity in the yeast Saccharomyces cerevisiae...
- Netz D, Genau H, Weiler B, Bill E, Pierik A, Lill R. The conserved protein Dre2 uses essential [2Fe-2S] and [4Fe-4S] clusters for its function in cytosolic iron-sulfur protein assembly. Biochem J. 2016;473:2073-85 pubmed publisher..Maturation is initiated by the electron transfer chain NADPH-diflavin reductase Tah18-Fe-S protein Dre2 that facilitates the de novo assembly of a [4Fe-4S] cluster on the scaffold complex Cfd1-Nbp35...
- Li H, Stümpfig M, Zhang C, An X, Stubbe J, Lill R, et al. The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. J Biol Chem. 2017;292:11445-11451 pubmed publisher..2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for ..