DOM34

Summary

Gene Symbol: DOM34
Description: ribosome dissociation factor DOM34
Alias: ribosome dissociation factor DOM34
Species: Saccharomyces cerevisiae S288c
Products:     DOM34

Top Publications

  1. Shoemaker C, Eyler D, Green R. Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay. Science. 2010;330:369-72 pubmed publisher
    ..Two interacting factors, Dom34 and Hbs1, are genetically implicated in NGD in yeast...
  2. van Wijlick L, Geissen R, Hilbig J, Lagadec Q, Cantero P, Pfeifer E, et al. Dom34 Links Translation to Protein O-mannosylation. PLoS Genet. 2016;12:e1006395 pubmed publisher
    In eukaryotes, Dom34 upregulates translation by securing levels of activatable ribosomal subunits...
  3. Doma M, Parker R. Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation. Nature. 2006;440:561-4 pubmed
    ..No-go decay provides a mechanism for clearing the cell of stalled translation elongation complexes, which could occur as a result of damaged mRNAs or ribosomes, or as a mechanism of post-transcriptional control. ..
  4. Guydosh N, Green R. Dom34 rescues ribosomes in 3' untranslated regions. Cell. 2014;156:950-62 pubmed publisher
    ..The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is ..
  5. Graille M, Chaillet M, van Tilbeurgh H. Structure of yeast Dom34: a protein related to translation termination factor Erf1 and involved in No-Go decay. J Biol Chem. 2008;283:7145-54 pubmed publisher
    The yeast protein Dom34 has been described to play a critical role in a newly identified mRNA decay pathway called No-Go decay. This pathway clears cells from mRNAs inducing translational stalls through endonucleolytic cleavage...
  6. van den Elzen A, Schuller A, Green R, Seraphin B. Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress. EMBO J. 2014;33:265-76 pubmed publisher
    ..The subunits of these inactive ribosomes need to be mobilized for translation restart upon stress relief. The Dom34-Hbs1 complex, together with the Rli1 NTPase (also known as ABCE1), have been shown to split ribosomes stuck on ..
  7. Armakola M, Higgins M, Figley M, Barmada S, Scarborough E, Diaz Z, et al. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012;44:1302-9 pubmed publisher
    ..Our findings provide insight into TDP-43-mediated cytotoxicity and suggest that decreasing Dbr1 activity could be a potential therapeutic approach for ALS. ..
  8. Soudet J, Gelugne J, Belhabich Baumas K, Caizergues Ferrer M, Mougin A. Immature small ribosomal subunits can engage in translation initiation in Saccharomyces cerevisiae. EMBO J. 2010;29:80-92 pubmed publisher
  9. Izawa T, Tsuboi T, Kuroha K, Inada T, Nishikawa S, Endo T. Roles of dom34:hbs1 in nonstop protein clearance from translocators for normal organelle protein influx. Cell Rep. 2012;2:447-53 pubmed publisher
    ..in the cytosol, but are instead released into the ER lumen through stalled ribosome and translocator channels by Dom34:Hbs1...

More Information

Publications20

  1. Becker T, Armache J, Jarasch A, Anger A, Villa E, Sieber H, et al. Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome. Nat Struct Mol Biol. 2011;18:715-20 pubmed publisher
    ..The key factors triggering NGD are Dom34 and Hbs1...
  2. Shoemaker C, Green R. Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast. Proc Natl Acad Sci U S A. 2011;108:E1392-8 pubmed publisher
    ..studies have proposed a direct role for eukaryotic termination factors eRF1 and eRF3 (and the related factors Dom34 and Hbs1) in downstream recycling processes; however, our understanding of the connection between termination and ..
  3. Tsuboi T, Kuroha K, Kudo K, Makino S, Inoue E, Kashima I, et al. Dom34:hbs1 plays a general role in quality-control systems by dissociation of a stalled ribosome at the 3' end of aberrant mRNA. Mol Cell. 2012;46:518-29 pubmed publisher
    ..It has been reported that the Dom34:Hbs1 complex stimulates this endonucleolytic cleavage of mRNA induced by translation arrest in vivo and ..
  4. Carr Schmid A, Pfund C, Craig E, Kinzy T. Novel G-protein complex whose requirement is linked to the translational status of the cell. Mol Cell Biol. 2002;22:2564-74 pubmed
    ..Thus, Hbs1p and Dom34p may function together to help directly or indirectly facilitate the expression either of specific mRNAs or under certain cellular conditions. ..
  5. Schilling V, Peifer C, Buchhaupt M, Lamberth S, Lioutikov A, Rietschel B, et al. Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. Yeast. 2012;29:167-83 pubmed publisher
    ..RPS18B, RRP8, EFG1, UTP30), to ribosome quality control (UBP3, BRE5, UBP6) and to ribosome functional control (DOM34, no-go decay). Deletions in ribosome quality and functional control genes were synthetically sick with ?nep1...
  6. Cole S, LaRiviere F, Merrikh C, Moore M. A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay. Mol Cell. 2009;34:440-50 pubmed publisher
    ..We propose that 18S NRD and NGD are different observable outcomes of the same initiating event: a ribosome stalled inappropriately at a sense codon during translation elongation. ..
  7. Lee H, Kim Y, Kim K, Heo I, Kim S, Kim O, et al. Structural and functional insights into Dom34, a key component of no-go mRNA decay. Mol Cell. 2007;27:938-50 pubmed publisher
    The yeast protein Dom34 is a key component of no-go decay, by which mRNAs with translational stalls are endonucleolytically cleaved and subsequently degraded. However, the identity of the endoribonuclease is unknown...
  8. Davis L, Engebrecht J. Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes. Genetics. 1998;149:45-56 pubmed
    The DOM34 gene of Saccharomyces cerevisiae is similar to genes found in diverse eukaryotes and archaebacteria...
  9. Balagopal V, Parker R. Stm1 modulates translation after 80S formation in Saccharomyces cerevisiae. RNA. 2011;17:835-42 pubmed publisher
    ..We demonstrate that in vitro Stm1 inhibits translation after formation of an 80S complex. This suggests that Stm1 modulates translation and mRNA decapping by controlling translation elongation. ..
  10. van den Elzen A, Henri J, Lazar N, Gas M, Durand D, Lacroute F, et al. Dissection of Dom34-Hbs1 reveals independent functions in two RNA quality control pathways. Nat Struct Mol Biol. 2010;17:1446-52 pubmed publisher
    ..b>Dom34 and Hbs1 are two proteins that are related to translation termination factors and are involved in no-go decay (NGD)..
  11. Passos D, Doma M, Shoemaker C, Muhlrad D, Green R, Weissman J, et al. Analysis of Dom34 and its function in no-go decay. Mol Biol Cell. 2009;20:3025-32 pubmed publisher
    ..The cleavage triggered by No-Go decay is dependent on Dom34p and Hbs1p, and Dom34 has been proposed to be the endonuclease responsible for mRNA cleavage...