Genomes and Genes
Gene Symbol: DOM34
Description: ribosome dissociation factor DOM34
Alias: ribosome dissociation factor DOM34
Species: Saccharomyces cerevisiae S288c
- Becker T, Armache J, Jarasch A, Anger A, Villa E, Sieber H, et al. Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome. Nat Struct Mol Biol. 2011;18:715-20 pubmed publisher..The key factors triggering NGD are Dom34 and Hbs1...
- Shoemaker C, Green R. Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast. Proc Natl Acad Sci U S A. 2011;108:E1392-8 pubmed publisher..studies have proposed a direct role for eukaryotic termination factors eRF1 and eRF3 (and the related factors Dom34 and Hbs1) in downstream recycling processes; however, our understanding of the connection between termination and ..
- Tsuboi T, Kuroha K, Kudo K, Makino S, Inoue E, Kashima I, et al. Dom34:hbs1 plays a general role in quality-control systems by dissociation of a stalled ribosome at the 3' end of aberrant mRNA. Mol Cell. 2012;46:518-29 pubmed publisher..It has been reported that the Dom34:Hbs1 complex stimulates this endonucleolytic cleavage of mRNA induced by translation arrest in vivo and ..
- Carr Schmid A, Pfund C, Craig E, Kinzy T. Novel G-protein complex whose requirement is linked to the translational status of the cell. Mol Cell Biol. 2002;22:2564-74 pubmed..Thus, Hbs1p and Dom34p may function together to help directly or indirectly facilitate the expression either of specific mRNAs or under certain cellular conditions. ..
- Schilling V, Peifer C, Buchhaupt M, Lamberth S, Lioutikov A, Rietschel B, et al. Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. Yeast. 2012;29:167-83 pubmed publisher..RPS18B, RRP8, EFG1, UTP30), to ribosome quality control (UBP3, BRE5, UBP6) and to ribosome functional control (DOM34, no-go decay). Deletions in ribosome quality and functional control genes were synthetically sick with ?nep1...
- Cole S, LaRiviere F, Merrikh C, Moore M. A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay. Mol Cell. 2009;34:440-50 pubmed publisher..We propose that 18S NRD and NGD are different observable outcomes of the same initiating event: a ribosome stalled inappropriately at a sense codon during translation elongation. ..
- Lee H, Kim Y, Kim K, Heo I, Kim S, Kim O, et al. Structural and functional insights into Dom34, a key component of no-go mRNA decay. Mol Cell. 2007;27:938-50 pubmed publisherThe yeast protein Dom34 is a key component of no-go decay, by which mRNAs with translational stalls are endonucleolytically cleaved and subsequently degraded. However, the identity of the endoribonuclease is unknown...
- Davis L, Engebrecht J. Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes. Genetics. 1998;149:45-56 pubmedThe DOM34 gene of Saccharomyces cerevisiae is similar to genes found in diverse eukaryotes and archaebacteria...
- Balagopal V, Parker R. Stm1 modulates translation after 80S formation in Saccharomyces cerevisiae. RNA. 2011;17:835-42 pubmed publisher..We demonstrate that in vitro Stm1 inhibits translation after formation of an 80S complex. This suggests that Stm1 modulates translation and mRNA decapping by controlling translation elongation. ..
- van den Elzen A, Henri J, Lazar N, Gas M, Durand D, Lacroute F, et al. Dissection of Dom34-Hbs1 reveals independent functions in two RNA quality control pathways. Nat Struct Mol Biol. 2010;17:1446-52 pubmed publisher..b>Dom34 and Hbs1 are two proteins that are related to translation termination factors and are involved in no-go decay (NGD)..
- Passos D, Doma M, Shoemaker C, Muhlrad D, Green R, Weissman J, et al. Analysis of Dom34 and its function in no-go decay. Mol Biol Cell. 2009;20:3025-32 pubmed publisher..The cleavage triggered by No-Go decay is dependent on Dom34p and Hbs1p, and Dom34 has been proposed to be the endonuclease responsible for mRNA cleavage...