DLD1

Summary

Gene Symbol: DLD1
Description: D-lactate dehydrogenase
Alias: D-lactate dehydrogenase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Rojo E, Guiard B, Neupert W, Stuart R. Sorting of D-lactate dehydrogenase to the inner membrane of mitochondria. Analysis of topogenic signal and energetic requirements. J Biol Chem. 1998;273:8040-7 pubmed
    ..This model also accounts for the driving force of translocation across the outer membrane, in the apparent absence of mt-Hsp70-dependent assisted import and involves the folding of the D-LD in the intermembrane space. ..
  2. Mourier A, Vallortigara J, Yoboue E, Rigoulet M, Devin A. Kinetic activation of yeast mitochondrial D-lactate dehydrogenase by carboxylic acids. Biochim Biophys Acta. 2008;1777:1283-8 pubmed publisher
    ..It is non-competitive, hyperbolic and its dimension is directly related to the number of carboxylic groups on the activator. The physiological meaning of such a regulation is discussed. ..
  3. Kim S, Bae S, Hahn J. Redirection of pyruvate flux toward desired metabolic pathways through substrate channeling between pyruvate kinase and pyruvate-converting enzymes in Saccharomyces cerevisiae. Sci Rep. 2016;6:24145 pubmed publisher
    ..This pyruvate channeling strategy led to an improvement of 2,3-butanediol production by 38%, while showing a limitation in improving lactic acid production due to a reduced activity of lactate dehydrogenase by dockerin tagging. ..
  4. Lodi T, Ferrero I. Isolation of the DLD gene of Saccharomyces cerevisiae encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase. Mol Gen Genet. 1993;238:315-24 pubmed
    ..These results are discussed together with the role of L-LCR and D-LCR in lactate metabolism of S. cerevisiae. ..
  5. Grandier Vazeille X, Bathany K, Chaignepain S, Camougrand N, Manon S, Schmitter J. Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Biochemistry. 2001;40:9758-69 pubmed
    ..The association of these proteins is discussed in terms of NADH-channeling. ..
  6. Becker Kettern J, Paczia N, Conrotte J, Kay D, Guignard C, Jung P, et al. Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. J Biol Chem. 2016;291:6036-58 pubmed publisher
    ..cerevisiae cells in a process that couples D-2HG metabolism to the shuttling of reducing equivalents from cytosolic NADH to the mitochondrial respiratory chain via the D-lactate dehydrogenase Dld1.