Genomes and Genes
Gene Symbol: DIG2
Alias: RST2, Dig2p
Species: Saccharomyces cerevisiae S288c
- Gelli A. Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast. Mol Microbiol. 2002;46:845-54 pubmed..and the MAP kinase Fus3 phosphorylates two specific repressor proteins Rst1 and Rst2 (also known as Dig1 and Dig2) to promote Ste12-dependent transcription of mating-specific genes...
- Breitkreutz A, Boucher L, Breitkreutz B, Sultan M, Jurisica I, Tyers M. Phenotypic and transcriptional plasticity directed by a yeast mitogen-activated protein kinase network. Genetics. 2003;165:997-1015 pubmed..and the transcriptional machinery consists of a network of two MAPKs, Fus3 and Kss1; two regulators, Rst1 and Rst2 (a.k.a. Dig1 and Dig2); and two transcription factors, Ste12 and Tec1...
- Blackwell E, Kim H, Stone D. The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2. BMC Cell Biol. 2007;8:44 pubmed..One possibility is that the activation of Fus3 changes its affinity for nuclear and cytoplasmic tethers. Dig1, Dig2, and Ste12 are nuclear proteins that interact with Fus3...
- Chen R, Thorner J. Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinase-dependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae. Genetics. 2010;185:855-70 pubmed publisher..Thus, although there are similarities between haploids and diploids, cell type-specific differences clearly alter the balance of the signaling inputs required to elicit the various nutrient limitation-evoked cellular behaviors. ..
- Houser J, Ford E, Nagiec M, Errede B, Elston T. Positive roles for negative regulators in the mating response of yeast. Mol Syst Biol. 2012;8:586 pubmed publisher..First, we found that the transcriptional repressors Dig1 and Dig2 positively affect transcription by stabilizing Ste12...
- Ranish J, Yi E, Leslie D, Purvine S, Goodlett D, Eng J, et al. The study of macromolecular complexes by quantitative proteomics. Nat Genet. 2003;33:349-55 pubmed