Genomes and Genes
Gene Symbol: DIG1
Alias: RST1, Dig1p
Species: Saccharomyces cerevisiae S288c
- Yu R, Pesce C, Colman Lerner A, Lok L, Pincus D, Serra E, et al. Negative feedback that improves information transmission in yeast signalling. Nature. 2008;456:755-61 pubmed publisher..Our work suggests that negative feedback is a general mechanism used in signalling systems to align dose responses and thereby increase the fidelity of information transmission. ..
- Breitkreutz A, Boucher L, Breitkreutz B, Sultan M, Jurisica I, Tyers M. Phenotypic and transcriptional plasticity directed by a yeast mitogen-activated protein kinase network. Genetics. 2003;165:997-1015 pubmed..MAPK module and the transcriptional machinery consists of a network of two MAPKs, Fus3 and Kss1; two regulators, Rst1 and Rst2 (a.k.a. Dig1 and Dig2); and two transcription factors, Ste12 and Tec1...
- Ranish J, Yi E, Leslie D, Purvine S, Goodlett D, Eng J, et al. The study of macromolecular complexes by quantitative proteomics. Nat Genet. 2003;33:349-55 pubmed
- Shock T, Thompson J, Yates J, Madhani H. Hog1 mitogen-activated protein kinase (MAPK) interrupts signal transduction between the Kss1 MAPK and the Tec1 transcription factor to maintain pathway specificity. Eukaryot Cell. 2009;8:606-16 pubmed publisher..the consensus S/TP MAPK phosphorylation sites on Tec1, its DNA-binding partner Ste12, or the associated regulators Dig1 or Dig2...
- Chen R, Thorner J. Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinase-dependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae. Genetics. 2010;185:855-70 pubmed publisher..Thus, although there are similarities between haploids and diploids, cell type-specific differences clearly alter the balance of the signaling inputs required to elicit the various nutrient limitation-evoked cellular behaviors. ..
- Pi H, Chien C, Fields S. Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p. Mol Cell Biol. 1997;17:6410-8 pubmed..By two-hybrid analysis, this minimal domain interacts with two negative regulators, Dig1p and Dig2p (also designated Rst1p and Rst2p), and the interaction is abolished by mutation of the tyrosines...
- Mangus D, Smith M, McSweeney J, Jacobson A. Identification of factors regulating poly(A) tail synthesis and maturation. Mol Cell Biol. 2004;24:4196-206 pubmed..ii) PBP1 itself, confirming directed two-hybrid results and suggesting that Pbp1p can multimerize; (iii) DIG1, encoding a mitogen-activated protein kinase-associated protein; and (iv) PBP4 (YDL053C), a previously ..
- Harbison C, Gordon D, Lee T, Rinaldi N, Macisaac K, Danford T, et al. Transcriptional regulatory code of a eukaryotic genome. Nature. 2004;431:99-104 pubmed..We find that environment-specific use of regulatory elements predicts mechanistic models for the function of a large population of yeast's transcriptional regulators. ..
- Gelli A. Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast. Mol Microbiol. 2002;46:845-54 pubmed..is activated, and the MAP kinase Fus3 phosphorylates two specific repressor proteins Rst1 and Rst2 (also known as Dig1 and Dig2) to promote Ste12-dependent transcription of mating-specific genes...
- Houser J, Ford E, Nagiec M, Errede B, Elston T. Positive roles for negative regulators in the mating response of yeast. Mol Syst Biol. 2012;8:586 pubmed publisher..First, we found that the transcriptional repressors Dig1 and Dig2 positively affect transcription by stabilizing Ste12...
- Ryan O, Shapiro R, Kurat C, Mayhew D, Baryshnikova A, Chin B, et al. Global gene deletion analysis exploring yeast filamentous growth. Science. 2012;337:1353-6 pubmed publisher..cerevisiae and C. albicans. ..
- Nakano A. Identification and characterization of extragenic suppressors of the yeast sec12 ts mutation. J Biochem. 1996;120:642-6 pubmed..rst2 and rst3 are recessive and give pleiotropic phenotypes including slow growth at low temperatures and heterogeneous modification of Sec12p. Their possible roles are discussed. ..
- Blackwell E, Kim H, Stone D. The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2. BMC Cell Biol. 2007;8:44 pubmed..One possibility is that the activation of Fus3 changes its affinity for nuclear and cytoplasmic tethers. Dig1, Dig2, and Ste12 are nuclear proteins that interact with Fus3...