DCR2

Summary

Gene Symbol: DCR2
Description: phosphoprotein phosphatase
Alias: phosphoprotein phosphatase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Pathak R, Bogomolnaya L, Guo J, Polymenis M. Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:1627-38 pubmed
    ..Here we report that in Saccharomyces cerevisiae overexpression of the dosage-dependent cell cycle regulator genes DCR2 (YLR361C) and GID8 (DCR1/YMR135C) accelerates initiation of DNA replication...
  2. Bogomolnaya L, Pathak R, Guo J, Polymenis M. Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae. Curr Genet. 2006;49:384-92 pubmed
    ..Taken together, our results point to a complex regulation of cell proliferation by RAM proteins, in a non-uniform manner that was not previously anticipated. ..
  3. Guo J, Polymenis M. Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae. EMBO Rep. 2006;7:1124-7 pubmed
    ..Here, we report that the dose-dependent cell-cycle regulator 2 (Dcr2) phosphatase functionally and physically interacts with Ire1...
  4. Pathak R, Blank H, Guo J, Ellis S, Polymenis M. The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2007;361:700-4 pubmed
    ..Our results identify a novel factor that affects the stability of Sic1p, possibly contributing to mechanisms that trigger initiation of cell division. ..