Gene Symbol: CYM1
Alias: MOP112, Cym1p
Species: Saccharomyces cerevisiae S288c
Kambacheld M, Augustin S, Tatsuta T, Muller S, Langer T. Role of the novel metallopeptidase Mop112 and saccharolysin for the complete degradation of proteins residing in different subcompartments of mitochondria. J Biol Chem. 2005;280:20132-9 pubmed
..Here we describe the identification of Mop112, a novel metallopeptidase of the pitrilysin family M16 localized in the intermembrane space of yeast mitochondria...
Alikhani N, Berglund A, Engmann T, Spånning E, Vögtle F, Pavlov P, et al
. Targeting capacity and conservation of PreP homologues localization in mitochondria of different species. J Mol Biol. 2011;410:400-10 pubmed publisher
..by presequence proteases (PrePs) identified in Arabidopsis thaliana (AtPreP), humans (hPreP), and yeast (Cym1/Mop112). The presequences of A...
Taskin A, Kucukkose C, Burger N, Mossmann D, Meisinger C, Vögtle F. The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing. Mol Biol Cell. 2017;28:997-1002 pubmed publisher
..Degradation of mitochondrial peptides is performed by Cym1 in yeast and its homologue, PreP, in humans...
Jønson L, Rehfeld J, Johnsen A. Enhanced peptide secretion by gene disruption of CYM1, a novel protease in Saccharomyces cerevisiae. Eur J Biochem. 2004;271:4788-97 pubmed
..b>Cym1p resembles metalloendoproteases of the pitrilysin family with the HXXEH(X)E(71-77) catalytic domain as seen in ..
Mossmann D, VÃ¶gtle F, Taskin A, Teixeira P, Ring J, Burkhart J, et al
. Amyloid-Î² peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab. 2014;20:662-9 pubmed publisher
..import, presequences are cleaved off by matrix processing peptidases and subsequently degraded by the peptidasome Cym1/PreP, which also degrades Amyloid-beta peptides (AÎ²)...
Joshi A, Fei N, Greenberg M. Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels. FEMS Yeast Res. 2016;16: pubmed publisher
..The genetic interactions observed in this study identify novel physiological modifiers that are required for maintenance of CL levels and mitochondrial morphology. ..