Gene Symbol: CYC7
Description: cytochrome c
Alias: cytochrome c
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Barrientos A, Pierre D, Lee J, Tzagoloff A. Cytochrome oxidase assembly does not require catalytically active cytochrome C. J Biol Chem. 2003;278:8881-7 pubmed
    b>Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the transfer of electrons from reduced cytochrome c to molecular oxygen...
  2. Allen L, Zhao X, Caughey W, Poyton R. Isoforms of yeast cytochrome c oxidase subunit V affect the binuclear reaction center and alter the kinetics of interaction with the isoforms of yeast cytochrome c. J Biol Chem. 1995;270:110-8 pubmed
    Subunit V, one of the nuclear-coded subunits of yeast cytochrome c oxidase, has two isoforms, Va and Vb. These alter the in vivo intramolecular rates of electron transfer within the holoenzyme (Waterland, R. A., Basu, A., Chance, B...
  3. McStay G, Su C, Thomas S, Xu J, Tzagoloff A. Characterization of assembly intermediates containing subunit 1 of yeast cytochrome oxidase. J Biol Chem. 2013;288:26546-56 pubmed publisher
  4. Wang X, Dumont M, Sherman F. Sequence requirements for mitochondrial import of yeast cytochrome c. J Biol Chem. 1996;271:6594-604 pubmed
    ..intermembrane space, and subsequently covalently attached to heme in a reaction catalyzed by the enzyme cytochrome c heme lyase...
  5. Bien M, Longen S, Wagener N, Chwalla I, Herrmann J, Riemer J. Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione. Mol Cell. 2010;37:516-28 pubmed publisher
    ..The generation of these side products is efficiently counteracted by reduced glutathione. Thus, our findings suggest a role for a glutathione-dependent proofreading during oxidative protein folding by the mitochondrial disulfide relay. ..
  6. Bestwick M, Jeong M, Khalimonchuk O, Kim H, Winge D. Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family. Mol Cell Biol. 2010;30:4480-91 pubmed publisher
    ..of the Leigh mutations, F(249)T and Y(344)D, in Shy1 failed to significantly attenuate the function of Shy1 in cytochrome c oxidase (CcO) biogenesis as seen with the human mutations...