Gene Symbol: CYC3
Description: holocytochrome c synthase CYC3
Alias: holocytochrome c synthase CYC3
Species: Saccharomyces cerevisiae S288c
Barros M, Tzagoloff A. Regulation of the heme A biosynthetic pathway in Saccharomyces cerevisiae. FEBS Lett. 2002;516:119-23 pubmed
..The heme profiles of the mutants also suggest positive regulation of heme B farnesylation by the hydroxylated intermediate formed at the subsequent step or by Cox15p itself. ..
Dumont M, Ernst J, Hampsey D, Sherman F. Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae. EMBO J. 1987;6:235-41 pubmed
..We demonstrate here that the nuclear gene, CYC3, in the yeast Saccharomyces cerevisiae, encodes cytochrome c heme lyase (CCHL), the enzyme catalyzing the ..
Dabir D, Leverich E, Kim S, Tsai F, Hirasawa M, Knaff D, et al
. A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1. EMBO J. 2007;26:4801-11 pubmed
..By coupling these pathways, cytochrome c and Ccp1 function efficiently as Erv1-dependent electron acceptors. Thus, we propose that Erv1 utilizes diverse pathways for electron shuttling in the IMS. ..
Dumont M, Cardillo T, Hayes M, Sherman F. Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11:5487-96 pubmed
..Altered apocytochrome c lacking the ability to have heme covalently attached accumulates in mitochondria only to the extent that it remains bound to heme lyase. ..
Corvest V, Murrey D, Hirasawa M, Knaff D, Guiard B, Hamel P. The flavoprotein Cyc2p, a mitochondrial cytochrome c assembly factor, is a NAD(P)H-dependent haem reductase. Mol Microbiol. 2012;83:968-80 pubmed publisher
..We postulate that Cyc2p, possibly in a complex with CCHL, reduces the haem iron prior to haem attachment to the apoforms of cytochrome c and c(1) . ..
Bernard D, Quevillon Cheruel S, Merchant S, Guiard B, Hamel P. Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes. J Biol Chem. 2005;280:39852-9 pubmed
..We postulate that, in vivo, Cyc2p interacts with CCHL and is involved in the reduction of heme prior to its ligation to apocytochrome c by CCHL. ..
Corvest V, Murrey D, Bernard D, Knaff D, Guiard B, Hamel P. c-type cytochrome assembly in Saccharomyces cerevisiae: a key residue for apocytochrome c1/lyase interaction. Genetics. 2010;186:561-71 pubmed publisher
..CC(1)HL-dependent assembly of holocytochrome c(1). We also provide evidence that Cyc2p is dedicated to the CCHL pathway and is not required for the CC(1)HL-dependent assembly of cytochrome c(1). ..