CUS2

Summary

Gene Symbol: CUS2
Description: U2 snRNP complex subunit CUS2
Alias: U2 snRNP complex subunit CUS2
Species: Saccharomyces cerevisiae S288c
Products:     CUS2

Top Publications

  1. Yan D, Perriman R, Igel H, Howe K, Neville M, Ares M. CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif. Mol Cell Biol. 1998;18:5000-9 pubmed
    A screen for suppressors of a U2 snRNA mutation identified CUS2, an atypical member of the RNA recognition motif (RRM) family of RNA binding proteins...
  2. Perriman R, Barta I, Voeltz G, Abelson J, Ares M. ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA. Proc Natl Acad Sci U S A. 2003;100:13857-62 pubmed
    ..Prp5p with an altered ATP-binding domain (Prp5-GNTp) can support growth in vivo, but only in a cus2 deletion strain, mirroring the in vitro results...
  3. Xu Y, Query C. Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly. Mol Cell. 2007;28:838-49 pubmed
  4. Perriman R, Ares M. Invariant U2 snRNA nucleotides form a stem loop to recognize the intron early in splicing. Mol Cell. 2010;38:416-27 pubmed publisher
  5. Rodgers M, Tretbar U, Dehaven A, Alwan A, Luo G, Mast H, et al. Conformational dynamics of stem II of the U2 snRNA. RNA. 2016;22:225-36 pubmed publisher
    ..Together these data suggest that multiple components of the spliceosome may have evolved to switch between conformations corresponding to open or closed active sites with the aid of metal and protein cofactors. ..
  6. Chathoth K, Barrass J, Webb S, Beggs J. A splicing-dependent transcriptional checkpoint associated with prespliceosome formation. Mol Cell. 2014;53:779-90 pubmed publisher
    ..at Ser5 of the largest subunit's heptad repeat accumulates over introns and that this defect requires Cus2 protein...
  7. Carrocci T, Zoerner D, Paulson J, Hoskins A. SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast. Nucleic Acids Res. 2017;45:4837-4852 pubmed publisher
    ..We propose that SF3b1 functions to stabilize weak U2/BS duplexes to drive spliceosome assembly and splicing. ..