Gene Symbol: CST6
Description: Cst6p
Alias: ACA2, SHF1, Cst6p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Garcia Gimeno M, Struhl K. Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol. 2000;20:4340-9 pubmed
    ..family of ATF/CREB transcriptional regulators consists of a repressor, Acr1 (Sko1), and two activators, Aca1 and Aca2. The AP-1 factor Gen4 does not activate transcription through ATF/CREB sites in vivo even though it binds these ..
  2. Saleem R, Rogers R, Ratushny A, Dilworth D, Shannon P, Shteynberg D, et al. Integrated phosphoproteomics analysis of a signaling network governing nutrient response and peroxisome induction. Mol Cell Proteomics. 2010;9:2076-88 pubmed publisher
    ..These include several transcription factors, two of which, Pip2p and Cst6p, must be phosphorylated for the normal transcriptional response of fatty acid-responsive loci encoding peroxisomal ..
  3. Liu G, Bergenholm D, Nielsen J. Genome-Wide Mapping of Binding Sites Reveals Multiple Biological Functions of the Transcription Factor Cst6p in Saccharomyces cerevisiae. MBio. 2016;7: pubmed publisher
    In the model eukaryote Saccharomyces cerevisiae, the transcription factor Cst6p has been reported to play important roles in several biological processes...
  4. Pohlers S, Martin R, Krüger T, Hellwig D, Hänel F, Kniemeyer O, et al. Lipid Signaling via Pkh1/2 Regulates Fungal CO2 Sensing through the Kinase Sch9. MBio. 2017;8: pubmed publisher
    ..To identify the kinase controlling Cst6/Rca1, we screened an S...
  5. Ouspenski I, Elledge S, Brinkley B. New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res. 1999;27:3001-8 pubmed
    ..we conclude that overexpression of CST4 specifically interferes with mitotic chromosome segregation, and CST6 affects some aspect of DNA metabolism. The other CST genes had complex pleiotropic phenotypes...
  6. Wohlschlegel J, Johnson E, Reed S, Yates J. Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem. 2004;279:45662-8 pubmed
    ..Additionally, our global analysis has revealed a number of interesting biological patterns in the list of SUMO targets including a clustering of sumoylation targets within macromolecular complexes. ..
  7. Holbein S, Wengi A, Decourty L, Freimoser F, Jacquier A, Dichtl B. Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation. RNA. 2009;15:837-49 pubmed publisher
    ..Finally, chemical-genetic profiling revealed genome-wide pathways linked to cordycepin activity and identified novel genes involved in poly(A) homeostasis. ..
  8. Cottier F, Raymond M, Kurzai O, Bolstad M, Leewattanapasuk W, Jimenez Lopez C, et al. The bZIP transcription factor Rca1p is a central regulator of a novel CO? sensing pathway in yeast. PLoS Pathog. 2012;8:e1002485 pubmed publisher
    ..ChIP-chip analysis and the identification of Rca1p orthologs in the model yeast Saccharomyces cerevisiae (Cst6p) point to the broad significance of this novel pathway in fungi...
  9. Rep M, Proft M, Remize F, Tamas M, Serrano R, Thevelein J, et al. The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol. 2001;40:1067-83 pubmed
    ..The five Sko1p target genes described here are suitable models for studying the interplay between osmotic and oxidative responses at the molecular and physiological levels. ..

More Information


  1. Steiner W, STEINER E. Fission yeast hotspot sequence motifs are also active in budding yeast. PLoS ONE. 2012;7:e53090 pubmed publisher
    ..cerevisiae. For one of these hotspots, M26 (also called CRE), we identify TFs, Cst6 and Sko1, that activate and inhibit the hotspot, respectively...