Gene Symbol: CSM2
Description: Csm2p
Alias: Csm2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Shor E, Weinstein J, Rothstein R. A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Genetics. 2005;169:1275-89 pubmed
    ..Here, we describe the analysis of four additional mutational suppressors of top3 defects: shu1, shu2, psy3, and csm2. These genes belong to one epistasis group and their protein products interact with each other, strongly suggesting ..
  2. Mankouri H, Ngo H, Hickson I. Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3. Mol Biol Cell. 2007;18:4062-73 pubmed
    b>CSM2, PSY3, SHU1, and SHU2 (collectively referred to as the SHU genes) were identified in Saccharomyces cerevisiae as four genes in the same epistasis group that suppress various sgs1 and top3 mutant phenotypes when mutated...
  3. Ball L, Zhang K, Cobb J, Boone C, Xiao W. The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol. 2009;73:89-102 pubmed publisher
    ..Furthermore, this screen identified and assigned four genes, CSM2, PSY3, SHU1 and SHU2, whose products form a stable Shu complex, to the error-free PRR pathway...
  4. Tao Y, Li X, Liu Y, Ruan J, Qi S, Niu L, et al. Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. J Biol Chem. 2012;287:20231-9 pubmed publisher
    The yeast Shu complex, consisting of the proteins Shu1, Shu2, Psy3, and Csm2, maintains genomic stability by coupling post-replication repair to homologous recombination...
  5. She Z, Gao Z, Liu Y, Wang W, Liu G, Shtykova E, et al. Structural and SAXS analysis of the budding yeast SHU-complex proteins. FEBS Lett. 2012;586:2306-12 pubmed publisher
    In Saccharomyces cerevisiae, four proteins, Shu1, Shu2, Psy3 and Csm2, form a stable SHU-complex both in vivo and in vitro. These proteins are involved in the early stages of the homologous recombination DNA damage repair process...
  6. Godin S, Wier A, Kabbinavar F, Bratton Palmer D, Ghodke H, Van Houten B, et al. The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination. Nucleic Acids Res. 2013;41:4525-34 pubmed publisher
    The Saccharomyces cerevisiae Shu complex, consisting of Shu1, Shu2, Csm2 and Psy3, promotes error-free homologous recombination (HR) by an unknown mechanism...
  7. Bernstein K, Reid R, Sunjevaric I, Demuth K, Burgess R, Rothstein R. The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Mol Biol Cell. 2011;22:1599-607 pubmed publisher
    ..We propose that the Shu complex shifts the balance of repair toward Rad51 filament stabilization by inhibiting the disassembly reaction of Srs2. ..
  8. Rabitsch K, Toth A, Galova M, Schleiffer A, Schaffner G, Aigner E, et al. A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol. 2001;11:1001-9 pubmed
    ..Reverse genetics using gene expression data is an effective method for identifying new genes involved in specific cellular processes. ..
  9. Choi K, Szakal B, Chen Y, Branzei D, Zhao X. The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell. 2010;21:2306-14 pubmed publisher

More Information


  1. Karras G, Fumasoni M, Sienski G, Vanoli F, Branzei D, Jentsch S. Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway. Mol Cell. 2013;49:536-46 pubmed publisher
    ..Our findings thus reveal unexpected cooperation in the error-free pathway between the two related clamps and indicate that 9-1-1 plays a broader role in the DNA damage response than previously assumed. ..
  2. Sasanuma H, Tawaramoto M, Lao J, Hosaka H, Sanda E, Suzuki M, et al. A new protein complex promoting the assembly of Rad51 filaments. Nat Commun. 2013;4:1676 pubmed publisher
    ..Here, we identify a new Rad51 mediator complex. The PCSS complex, comprising budding yeast Psy3, Csm2, Shu1 and Shu2 proteins, binds to recombination sites and is required for Rad51 assembly and function during ..
  3. Gaines W, Godin S, Kabbinavar F, Rao T, VanDemark A, Sung P, et al. Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52. Nat Commun. 2015;6:7834 pubmed publisher
    The conserved budding yeast Rad51 paralogues, including Rad55, Rad57, Csm2 and Psy3 are indispensable for homologous recombination (HR)-mediated chromosome damage repair...
  4. Godin S, Zhang Z, Herken B, Westmoreland J, Lee A, Mihalevic M, et al. The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products. Nucleic Acids Res. 2016;44:8199-215 pubmed publisher
    ..Together, our work demonstrates that the Shu complex's promotion of Rad51 pre-synaptic filaments is critical for high-fidelity bypass of multiple replication-blocking lesion. ..
  5. Zhang S, Wang L, Tao Y, Bai T, Lu R, Zhang T, et al. Structural basis for the functional role of the Shu complex in homologous recombination. Nucleic Acids Res. 2017;45:13068-13079 pubmed publisher
    The Shu complex, a conserved regulator consisting of Csm2, Psy3, Shu1 and Shu2 in budding yeast, plays an important role in the assembly of the Rad51-ssDNA filament in homologous recombination...
  6. Xu X, Ball L, Chen W, Tian X, Lambrecht A, Hanna M, et al. The yeast Shu complex utilizes homologous recombination machinery for error-free lesion bypass via physical interaction with a Rad51 paralogue. PLoS ONE. 2013;8:e81371 pubmed publisher
    ..Here we report that the Csm2 subunit of Shu physically interacts with Rad55, an accessory protein involved in HR...