CSM1

Summary

Gene Symbol: CSM1
Description: Csm1p
Alias: Csm1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Corbett K, Harrison S. Molecular architecture of the yeast monopolin complex. Cell Rep. 2012;1:583-9 pubmed publisher
    ..The monopolin subunits Csm1 and Lrs4 form a V-shaped complex that may directly crosslink sister kinetochores...
  2. Petronczki M, Matos J, Mori S, Gregan J, Bogdanova A, Schwickart M, et al. Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1. Cell. 2006;126:1049-64 pubmed
  3. Corbett K, Yip C, Ee L, Walz T, Amon A, Harrison S. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010;142:556-67 pubmed publisher
    ..We show here that the S. cerevisiae Csm1/Lrs4 monopolin subcomplex has a distinctive V-shaped structure, with two pairs of protein-protein interaction ..
  4. Brito I, Monje Casas F, Amon A. The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation. Cell Cycle. 2010;9:3611-8 pubmed
    Lrs4 and Csm1, components of the monopolin complex, localize to the rDNA where they regulate rDNA maintenance and segregation...
  5. Rabitsch K, Petronczki M, Javerzat J, Genier S, Chwalla B, Schleiffer A, et al. Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell. 2003;4:535-48 pubmed
    ..We describe here the identification of a protein complex, Csm1/Lrs4, that is essential for monoorientation of sister kinetochores in Saccharomyces cerevisiae...
  6. Johzuka K, Horiuchi T. The cis element and factors required for condensin recruitment to chromosomes. Mol Cell. 2009;34:26-35 pubmed publisher
    ..Instead, by genetic screening, we identified three genes, TOF2, CSM1, and LRS4, required both for condensin recruitment to the RFB site and for assuring the segregation of rDNA repeats...
  7. Rabitsch K, Toth A, Galova M, Schleiffer A, Schaffner G, Aigner E, et al. A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol. 2001;11:1001-9 pubmed
    ..Reverse genetics using gene expression data is an effective method for identifying new genes involved in specific cellular processes. ..
  8. Wysocka M, Rytka J, Kurlandzka A. Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex. Exp Cell Res. 2004;294:592-602 pubmed
    ..The level of Csm1p does not change throughout the cell cycle, but this protein is absent in mature spores...
  9. Mekhail K, Seebacher J, Gygi S, Moazed D. Role for perinuclear chromosome tethering in maintenance of genome stability. Nature. 2008;456:667-70 pubmed publisher
    ..Our results therefore reveal an ancient mechanism in which interactions between INM proteins and chromosomal proteins ensure genome stability. ..

More Information

Publications10

  1. Sarkar S, Shenoy R, Dalgaard J, Newnham L, Hoffmann E, Millar J, et al. Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I. PLoS Genet. 2013;9:e1003610 pubmed publisher
    ..depends on a four component protein complex referred to as monopolin which consists of two nucleolar proteins Csm1 and Lrs4, meiosis-specific protein Mam1 of unknown function and casein kinase Hrr25...