Gene Symbol: CPR1
Description: peptidylprolyl isomerase CPR1
Alias: CPH1, CYP1, peptidylprolyl isomerase CPR1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Wu X, Wilcox C, Devasahayam G, Hackett R, Ar valo Rodr guez M, Cardenas M, et al. The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. EMBO J. 2000;19:3727-38 pubmed publisher
    ..In this model, Ess1 binds and isomerizes the CTD of RNA polymerase II, thus altering its interaction with proteins required for transcription of essential cell cycle genes...
  2. Denison C, Rudner A, Gerber S, Bakalarski C, Moazed D, Gygi S. A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics. 2005;4:246-54 pubmed
    ..These data combine with recent works to further our understanding of the breadth and impact of protein sumoylation in a diverse array of biological processes. ..
  3. Breuder T, Hemenway C, Movva N, Cardenas M, Heitman J. Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. Proc Natl Acad Sci U S A. 1994;91:5372-6 pubmed
    ..In yeast strains in which calcineurin is not essential, calcineurin inhibition or mutation of calcineurin confers hypersensitivity to LiCl or NaCl, suggesting that calcineurin regulates cation transport. ..
  4. Shevchenko A, Schaft D, Roguev A, Pijnappel W, Stewart A, Shevchenko A. Deciphering protein complexes and protein interaction networks by tandem affinity purification and mass spectrometry: analytical perspective. Mol Cell Proteomics. 2002;1:204-12 pubmed
    ..Concordance with the results of genome-wide two-hybrid screening was poor (14% of identified interactors overlapped) suggesting that the two approaches may provide complementary views on physical interactions within the proteome. ..
  5. Ansari H, Greco G, Luban J. Cyclophilin A peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export. Mol Cell Biol. 2002;22:6993-7003 pubmed
    ..a phenotype that is suggestive of Cpr1p's function in a cpr1Delta Saccharomyces cerevisiae strain, we screened for CPR1-dependent strains...
  6. Arevalo Rodriguez M, Heitman J. Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. Eukaryot Cell. 2005;4:17-29 pubmed
    ..Our findings reveal a novel nuclear role for cyclophilin A in governing the transcriptional program required for the vegetative to meiotic developmental switch in budding yeast. ..
  7. Brown C, Cui D, Hung G, Chiang H. Cyclophilin A mediates Vid22p function in the import of fructose-1,6-bisphosphatase into Vid vesicles. J Biol Chem. 2001;276:48017-26 pubmed
    ..Our results suggest that Cpr1p mediates Vid22p function and is directly involved in the import of FBPase into Vid vesicles. ..
  8. Kim I, Kim H, Shin S, Kim Y, Lee D, Park K, et al. A cyclophilin A CPR1 overexpression enhances stress acquisition in Saccharomyces cerevisiae. Mol Cells. 2010;29:567-74 pubmed publisher
    ..We found the expression of cyclophilin A, Cpr1, changes in response to exposure to yeast Saccharomyces cerevisiae to abiotic stress conditions...
  9. Coaker G, Falick A, Staskawicz B. Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin. Science. 2005;308:548-50 pubmed
    ..AvrRpt2 is delivered into the plant cell, where it is activated by a eukaryotic factor that we identify as cyclophilin. This activation of AvrRpt2 is necessary for protease activity. Active AvrRpt2 can then directly cleave RIN4. ..

More Information


  1. Haendler B, Keller R, Hiestand P, Kocher H, Wegmann G, Movva N. Yeast cyclophilin: isolation and characterization of the protein, cDNA and gene. Gene. 1989;83:39-46 pubmed
    ..Purified yeast CPH exhibits peptidyl-prolyl cis-trans isomerase activity, albeit to a far lesser extent than the mammalian protein. ..
  2. Vögtle F, Burkhart J, Rao S, Gerbeth C, Hinrichs J, Martinou J, et al. Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics. 2012;11:1840-52 pubmed publisher
    ..We present here the first and comprehensive proteome of IMS proteins of yeast mitochondria with 51 proteins in total. The IMS proteome will serve as a valuable source for further studies on the role of the IMS in cell life and death. ..
  3. Möckli N, Deplazes A, Hassa P, Zhang Z, Peter M, Hottiger M, et al. Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. Biotechniques. 2007;42:725-30 pubmed
    ..The cytoY2H system extends existing methods for the detection of protein interactions by providing a convenient solution for screening a wide range of transcriptionally active proteins. ..
  4. Kovalev N, Nagy P. Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly. J Virol. 2013;87:13330-42 pubmed publisher
    ..Overall, the current work has revealed a regulatory role for the cytosolic single-domain Cpr1-like cyclophilins in RNA virus replication.
  5. Arevalo Rodriguez M, Cardenas M, Wu X, Hanes S, Heitman J. Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. EMBO J. 2000;19:3739-49 pubmed
    ..Our findings support a model in which Ess1 and cyclophilin A modulate the activity of the Sin3-Rpd3 complex, and excess histone deacetylation causes mitotic arrest in ess1 mutants. ..
  6. Mendu V, Chiu M, Barajas D, Li Z, Nagy P. Cpr1 cyclophilin and Ess1 parvulin prolyl isomerases interact with the tombusvirus replication protein and inhibit viral replication in yeast model host. Virology. 2010;406:342-51 pubmed publisher
    ..Replication of Tomato bushy stunt virus replicon RNA increased in cpr1? yeast, while over-expression of Cpr1p decreased viral replication...
  7. Parent S, Nielsen J, Morin N, Chrebet G, Ramadan N, Dahl A, et al. Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae. J Gen Microbiol. 1993;139:2973-84 pubmed
    ..Disruption of the gene encoding FKBP12 (FKB1) or the major, cytosolic cyclophilin (CPH1) in fks1 cells results in the loss of hypersensitivity to the relevant drug...
  8. Pijnappel W, Schaft D, Roguev A, Shevchenko A, Tekotte H, Wilm M, et al. The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev. 2001;15:2991-3004 pubmed
    ..We found that Set3 forms a single complex, Set3C, with Snt1, YIL112w, Sif2, Cpr1, and two putative histone deacetylases, Hos2 and NAD-dependent Hst1...