Gene Symbol: COX18
Description: membrane insertase COX18
Alias: OXA2, membrane insertase COX18
Species: Saccharomyces cerevisiae S288c
Fiumera H, Broadley S, Fox T. Translocation of mitochondrially synthesized Cox2 domains from the matrix to the intermembrane space. Mol Cell Biol. 2007;27:4664-73 pubmed
..was largely but not completely unaffected in mutants lacking proteins required for export of the C-tail domain, Cox18 and Mss2...
Fiumera H, Dunham M, Saracco S, Butler C, Kelly J, Fox T. Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18. Genetics. 2009;182:519-28 pubmed publisher
..In Saccharomyces cerevisiae, Oxa1 and its paralog, Cox18, are required for assembly of Cox2, a mitochondrially encoded subunit of cytochrome c oxidase...
Price C, Otto A, Fusetti F, Becher D, Hecker M, Driessen A. Differential effect of YidC depletion on the membrane proteome of Escherichia coli under aerobic and anaerobic growth conditions. Proteomics. 2010;10:3235-47 pubmed publisher
..These included the small metal ion transporter CorA, numerous ABC transporters, as well as the MFS transporters KgtP and ProP, providing a new subset of proteins potentially requiring YidC for membrane biogenesis. ..
Saracco S, Fox T. Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Mol Biol Cell. 2002;13:1122-31 pubmed
..We obtained multiple alleles of COX18, PNT1, and MSS2, as well as mutations in CBP1 and PET309...
van Bloois E, Koningstein G, Bauerschmitt H, Herrmann J, Luirink J. Saccharomyces cerevisiae Cox18 complements the essential Sec-independent function of Escherichia coli YidC. FEBS J. 2007;274:5704-13 pubmed
..Mitochondria of higher eukaryotes contain two distant homologues of YidC: Oxa1 and Cox18/Oxa2. Oxa1 is required for the insertion of membrane proteins into the mitochondrial inner membrane...
Elliott L, Saracco S, Fox T. Multiple roles of the Cox20 chaperone in assembly of Saccharomyces cerevisiae cytochrome c oxidase. Genetics. 2012;190:559-67 pubmed publisher
..The Cox2 C-tail domain is exported post-translationally by the highly conserved translocase Cox18 and associated proteins. We have found that Cox20 is required for efficient export of the Cox2 C-tail...