Gene Symbol: COX13
Description: cytochrome c oxidase subunit VIa
Alias: cytochrome c oxidase subunit VIa
Species: Saccharomyces cerevisiae S288c
Taanman J, Capaldi R. Subunit VIa of yeast cytochrome c oxidase is not necessary for assembly of the enzyme complex but modulates the enzyme activity. Isolation and characterization of the nuclear-coded gene. J Biol Chem. 1993;268:18754-61 pubmed
COX13, the nuclear gene for cytochrome c oxidase subunit VIa of Saccharomyces cerevisiae, has been isolated in two steps...
Chen Y, Taylor E, Dephoure N, Heo J, Tonhato A, Papandreou I, et al
. Identification of a protein mediating respiratory supercomplex stability. Cell Metab. 2012;15:348-60 pubmed publisher
..We suggest that Rcf1 is a member of an evolutionarily conserved protein family that acts to promote respiratory supercomplex assembly and activity. ..
McStay G, Su C, Thomas S, Xu J, Tzagoloff A. Characterization of assembly intermediates containing subunit 1 of yeast cytochrome oxidase. J Biol Chem. 2013;288:26546-56 pubmed publisher
Geier B, Schagger H, Ortwein C, Link T, Hagen W, Brandt U, et al
. Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method. Eur J Biochem. 1995;227:296-302 pubmed
..This high content of fast enzyme was also reflected in the characteristics of optical and EPR spectra for cytochrome-c oxidase purified with our method. ..
Gebert M, Schrempp S, Mehnert C, Heißwolf A, Oeljeklaus S, Ieva R, et al
. Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes. J Cell Biol. 2012;197:595-604 pubmed publisher
..We conclude that Mgr2 is a coupling factor of the presequence translocase crucial for cell growth at elevated temperature and for efficient protein import. ..
Su C, McStay G, Tzagoloff A. The Cox3p assembly module of yeast cytochrome oxidase. Mol Biol Cell. 2014;25:965-76 pubmed publisher
..These studies support our proposal that Cox3p and Cox1p are separate assembly modules with unique compositions of ancillary factors and subunits derived from the nuclear genome. ..
Taanman J, Capaldi R. Purification of yeast cytochrome c oxidase with a subunit composition resembling the mammalian enzyme. J Biol Chem. 1992;267:22481-5 pubmed
..The enzyme isolated in lauryl maltoside contains these same nine different polypeptides and three others, including homologues of subunits VIa and VIb of the mammalian enzyme. ..
Beauvoit B, Bunoust O, Guerin B, Rigoulet M. ATP-regulation of cytochrome oxidase in yeast mitochondria: role of subunit VIa. Eur J Biochem. 1999;263:118-27 pubmed
..This study opens up new prospects for understanding the feedback regulation of the respiratory chain by ATP. ..
Meunier B, Maréchal A, Rich P. Construction of histidine-tagged yeast mitochondrial cytochrome c oxidase for facile purification of mutant forms. Biochem J. 2012;444:199-204 pubmed publisher
..purification of a WT (wild-type) mitochondrial CcO, 6H-WT (yeast CcO with a 6H tag on the nuclear-encoded Cox13 subunit), with a recovery yield of 45%...