Gene Symbol: COX10
Description: protoheme IX farnesyltransferase
Alias: protoheme IX farnesyltransferase
Species: Saccharomyces cerevisiae S288c
Bestwick M, Khalimonchuk O, Pierrel F, Winge D. The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10. Mol Cell Biol. 2010;30:172-85 pubmed publisher
..The respiratory deficiency of coa2 Delta cells is suppressed either by the presence of a mutant allele of the Cox10 farnesyl transferase involved in heme a biosynthesis or through impaired proteolysis by the disruption of the ..
Khalimonchuk O, Kim H, Watts T, Perez Martinez X, Winge D. Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2. J Biol Chem. 2012;287:26715-26 pubmed publisher
..the heme a cofactor used in cytochrome c oxidase (CcO) is dependent on the sequential action of heme o synthase (Cox10) and heme a synthase (Cox15)...
Tzagoloff A, Nobrega M, Gorman N, Sinclair P. On the functions of the yeast COX10 and COX11 gene products. Biochem Mol Biol Int. 1993;31:593-8 pubmed
b>COX10 and COX11 are nuclear genes of Saccharomyces cerevisiae whose products are localized in mitochondria and are required for the synthesis of cytochrome oxidase...
Pierrel F, Bestwick M, Cobine P, Khalimonchuk O, Cricco J, Winge D. Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly. EMBO J. 2007;26:4335-46 pubmed
..The respiratory defect in coa1Delta cells is suppressed by high-copy MSS51, MDJ1 and COX10. Mss51 functions in Cox1 translation and elongation, whereas Cox10 participates in the biosynthesis of heme a, a ..
Wang Z, Wang Y, Hegg E. Regulation of the heme A biosynthetic pathway: differential regulation of heme A synthase and heme O synthase in Saccharomyces cerevisiae. J Biol Chem. 2009;284:839-47 pubmed publisher
..In eukaryotes, two inner mitochondrial membrane proteins, heme O synthase (Cox10) and heme A synthase (Cox15), are required for heme A biosynthesis...
Bestwick M, Jeong M, Khalimonchuk O, Kim H, Winge D. Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family. Mol Cell Biol. 2010;30:4480-91 pubmed publisher
..A genetic screen for allele-specific suppressors of the G(137)E Shy1 mutant revealed Coa2, Cox10, and a novel factor designated Coa4. Coa2 and Cox10 are previously characterized CcO assembly factors...
Pierrel F, Khalimonchuk O, Cobine P, Bestwick M, Winge D. Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1. Mol Cell Biol. 2008;28:4927-39 pubmed publisher
..Overexpression of Cox10 or Cox5a and Cox6 or attenuation of the proteolytic activity of the m-AAA protease partially restores respiration ..