Gene Symbol: COQ2
Description: 4-hydroxybenzoate octaprenyltransferase
Alias: 4-hydroxybenzoate octaprenyltransferase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Ashby M, Kutsunai S, Ackerman S, Tzagoloff A, Edwards P. COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase. J Biol Chem. 1992;267:4128-36 pubmed
    ..side chain and subsequent transfer to para-hydroxybenzoate (PHB) are encoded by the nuclear genes COQ1 and COQ2, respectively...
  2. Melzer M, Heide L. Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli. Biochim Biophys Acta. 1994;1212:93-102 pubmed
    ..The amino acid sequence shows striking similarities to 4-HB hexaprenyltransferase from yeast. Sequence homologies to other prenyltransferases are discussed. ..
  3. Ohara K, Kokado Y, Yamamoto H, Sato F, Yazaki K. Engineering of ubiquinone biosynthesis using the yeast coq2 gene confers oxidative stress tolerance in transgenic tobacco. Plant J. 2004;40:734-43 pubmed
    ..UQ biosynthesis was modified by overexpressing the yeast gene coq2, which encodes p-hydroxybenzoate:polyprenyltransferase, to increase the accumulation of UQ-6 in yeast and UQ-10 in ..
  4. Desbats M, Morbidoni V, Silic Benussi M, Doimo M, Ciminale V, Cassina M, et al. The COQ2 genotype predicts the severity of coenzyme Q10 deficiency. Hum Mol Genet. 2016;25:4256-4265 pubmed publisher
    b>COQ2 (p-hydroxybenzoate polyprenyl transferase) encodes the enzyme required for the second step of the final reaction sequence of Coenzyme Q10 (CoQ) biosynthesis...
  5. Payet L, Leroux M, Willison J, Kihara A, Pelosi L, Pierrel F. Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast. Cell Chem Biol. 2016;23:1241-1250 pubmed publisher
  6. Casey J, Threlfall D. Formation of 3-hexaprenyl-4-hydroxybenzoate by matrix-free mitochondrial membrane-rich preparations of yeast. Biochim Biophys Acta. 1978;530:487-502 pubmed
    ..No evidence was obtained for the involvement of either 4-hydroxybenzoyl CoA or 4-hydroxybenzoyl-S-protein in the formation of 3-polyprenyl-4-hydroxybenzoates. ..
  7. Suzuki K, Ueda M, Yuasa M, Nakagawa T, Kawamukai M, Matsuda H. Evidence that Escherichia coli ubiA product is a functional homolog of yeast COQ2, and the regulation of ubiA gene expression. Biosci Biotechnol Biochem. 1994;58:1814-9 pubmed
    ..The respiration-defective phenotype of the ubiA mutant was complemented by expression of the COQ2 gene encoding the 4-hydroxy benzoate hexaprenyl transferase of Saccharomyces cerevisiae and such strains produced ..
  8. Leuenberger D, Bally N, Schatz G, Koehler C. Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J. 1999;18:4816-22 pubmed
    ..Yeast mitochondria thus use multiple pathways for escorting hydrophobic inner membrane proteins across the aqueous intermembrane space. ..
  9. Gin P, Clarke C. Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase. J Biol Chem. 2005;280:2676-81 pubmed
    ..These data suggest that the lipid product of Coq1p or a Q-intermediate derived from polyprenyl diphosphate is involved in stabilizing the Coq3, Coq4, and Coq6 polypeptides. ..

More Information


  1. Barros M, Johnson A, Gin P, Marbois B, Clarke C, Tzagoloff A. The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration. J Biol Chem. 2005;280:42627-35 pubmed
    ..Both activities are restored by exogenous coenzyme Q2. Respiration is also partially rescued by COQ2, COQ7, or COQ8/ABC1, when these genes are present in high copy...
  2. James A, Cocheme H, Murai M, Miyoshi H, Murphy M. Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain. FEBS J. 2010;277:2067-82 pubmed publisher
    ..Here we suggest that CoQ or its redox state may be a signal for growth during the shift to respiration. ..