Genomes and Genes
Gene Symbol: COG3
Description: Golgi transport complex subunit COG3
Alias: GRD20, SEC34, Golgi transport complex subunit COG3
Species: Saccharomyces cerevisiae S288c
- Friedmann E, Salzberg Y, Weinberger A, Shaltiel S, Gerst J. YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. J Biol Chem. 2002;277:35274-81 pubmed..YOS9 interacts genetically with genes involved in ER-Golgi transport, particularly SEC34, whose temperature-sensitive mutant is rescued by YOS9 overexpression...
- Yen W, Shintani T, Nair U, Cao Y, Richardson B, Li Z, et al. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol. 2010;188:101-14 pubmed publisher..In addition, mutations in the COG genes resulted in the mislocalization of Atg8 and Atg9, which are critical components involved in autophagosome formation...
- Lees J, Yip C, Walz T, Hughson F. Molecular organization of the COG vesicle tethering complex. Nat Struct Mol Biol. 2010;17:1292-7 pubmed publisher..example, the conserved oligomeric Golgi (COG) complex, we reconstituted its essential subunits (Cog1, Cog2, Cog3 and Cog4) and used single-particle electron microscopy to reveal a y-shaped structure with three flexible, highly ..
- Shemorry A, Hwang C, Varshavsky A. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell. 2013;50:540-51 pubmed publisher..Cog1, a subunit of the Golgi-associated COG complex, is also shown to contain an Ac/N-degron. Cog2 and Cog3, direct ligands of Cog1, can repress this degron...