Gene Symbol: COG1
Description: Golgi transport complex subunit COG1
Alias: COD3, LDB11, SEC36, Golgi transport complex subunit COG1
Species: Saccharomyces cerevisiae S288c
Whyte J, Munro S. The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. Dev Cell. 2001;1:527-37 pubmed
Suvorova E, Duden R, Lupashin V. The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins. J Cell Biol. 2002;157:631-43 pubmed
..We propose that the Sec34/35 protein complex acts as a tether that connects cis-Golgi membranes and COPI-coated, retrogradely targeted intra-Golgi vesicles. ..
Fotso P, Koryakina Y, Pavliv O, Tsiomenko A, Lupashin V. Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. J Biol Chem. 2005;280:27613-23 pubmed
..The COG complex is composed of eight subunits that are located in two lobes; Lobe A contains COG1-4, and Lobe B is composed of COG5-8...
Shestakova A, Suvorova E, Pavliv O, Khaidakova G, Lupashin V. Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability. J Cell Biol. 2007;179:1179-92 pubmed
..These data suggest that the COG complex orchestrates vesicular trafficking similarly in yeast and mammalian cells by binding to the t-SNARE Syntaxin5a/Sed5p and enhancing the stability of intra-Golgi SNARE complexes. ..
Kurischko C, Kuravi V, Wannissorn N, Nazarov P, Husain M, Zhang C, et al
. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol Biol Cell. 2008;19:5559-78 pubmed publisher
..These data suggest that an important function for Cbk1 and the RAM signaling network is to regulate growth and secretion via Golgi and Sec2/Sec4-dependent processes. ..
Yen W, Shintani T, Nair U, Cao Y, Richardson B, Li Z, et al
. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol. 2010;188:101-14 pubmed publisher
..In addition, mutations in the COG genes resulted in the mislocalization of Atg8 and Atg9, which are critical components involved in autophagosome formation...
Lees J, Yip C, Walz T, Hughson F. Molecular organization of the COG vesicle tethering complex. Nat Struct Mol Biol. 2010;17:1292-7 pubmed publisher
..of one well-studied example, the conserved oligomeric Golgi (COG) complex, we reconstituted its essential subunits (Cog1, Cog2, Cog3 and Cog4) and used single-particle electron microscopy to reveal a y-shaped structure with three ..
Shemorry A, Hwang C, Varshavsky A. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell. 2013;50:540-51 pubmed publisher
..b>Cog1, a subunit of the Golgi-associated COG complex, is also shown to contain an Ac/N-degron...