Gene Symbol: COA3
Alias: COX25, RRG10, Coa3p
Species: Saccharomyces cerevisiae S288c
Mick D, Vukotic M, Piechura H, Meyer H, Warscheid B, Deckers M, et al
. Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria. J Cell Biol. 2010;191:141-54 pubmed publisher
..In this study, we identify Coa3 (cytochrome oxidase assembly factor 3; Yjl062w-A), a novel regulator of mitochondrial COX1 translation and ..
Reinhold R, Bareth B, Balleininger M, Wissel M, Rehling P, Mick D. Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Hum Mol Genet. 2011;20:2379-93 pubmed publisher
..Thus, exchanging the conserved tyrosine (Y(344)) with aspartate in yeast uncouples translational regulation of Cox1 from cytochrome c oxidase assembly and provides evidence for the dual functionality of Shy1. ..
McStay G, Su C, Tzagoloff A. Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex. FEBS Lett. 2013;587:943-9 pubmed publisher
Cox14p and Coa3p have been shown to regulate translation of the mitochondrial COX1 mRNA and to be required for assembly of cytochrome oxidase...
Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick D, Helbig C, et al
. Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell. 2016;27:1570-80 pubmed publisher
..Our analyses show that Oms1 participates in cytochrome c oxidase assembly by stabilizing newly synthesized Cox1. ..
Fontanesi F, Clemente P, Barrientos A. Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae. J Biol Chem. 2011;286:555-66 pubmed publisher
..Here we present evidence showing that Cox25 is a new essential COX assembly factor that plays some roles similar to Cox14...