Gene Symbol: COA1
Species: Saccharomyces cerevisiae S288c
Mick D, Wagner K, van der Laan M, Frazier A, Perschil I, Pawlas M, et al
. Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly. EMBO J. 2007;26:4347-58 pubmed
..Formation of these subcomplexes depends on Coa1 (YIL157c), a novel assembly factor that cooperates with Shy1...
Pierrel F, Bestwick M, Cobine P, Khalimonchuk O, Cricco J, Winge D. Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly. EMBO J. 2007;26:4335-46 pubmed
..of cytochrome c oxidase (CcO) in yeast mitochondria is shown to be dependent on a new assembly factor designated Coa1 that associates with the mitochondrial inner membrane...
Mick D, Vukotic M, Piechura H, Meyer H, Warscheid B, Deckers M, et al
. Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria. J Cell Biol. 2010;191:141-54 pubmed publisher
..Our data indicate that Coa1 binding to sequestered Mss51 in complex with Cox14, Coa3, and Cox1 is essential for full inactivation.
Reinhold R, Bareth B, Balleininger M, Wissel M, Rehling P, Mick D. Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Hum Mol Genet. 2011;20:2379-93 pubmed publisher
..Thus, exchanging the conserved tyrosine (Y(344)) with aspartate in yeast uncouples translational regulation of Cox1 from cytochrome c oxidase assembly and provides evidence for the dual functionality of Shy1. ..
Pierrel F, Khalimonchuk O, Cobine P, Bestwick M, Winge D. Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1. Mol Cell Biol. 2008;28:4927-39 pubmed publisher
..Coa2 was identified from its ability to suppress the respiratory deficiency of coa1Delta and shy1Delta cells. Coa1 and Shy1 function at an early step in maturation of the Cox1 subunit of CcO...
Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick D, Helbig C, et al
. Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell. 2016;27:1570-80 pubmed publisher
..Here we isolate a cytochrome c oxidase assembly intermediate in preparatory scale from coa1? mutant cells, using Mss51 as bait...