CNB1

Summary

Gene Symbol: CNB1
Description: calcineurin regulatory subunit B
Alias: CRV1, YCN2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
    A M Stathopoulos
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Genes Dev 11:3432-44. 1997
  2. pmc Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin
    C Zhao
    Department of Biochemistry, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 18:1013-22. 1998
  3. pmc Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90 and inhibited by calcineurin and Cmk2 in response to endoplasmic reticulum stresses
    Drew D Dudgeon
    Department of Biology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Eukaryot Cell 7:2037-51. 2008
  4. ncbi Identification of a novel region critical for calcineurin function in vivo and in vitro
    B Jiang
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Biol Chem 274:18543-51. 1999
  5. doi Vcx1-D1 (M383I), the Vcx1 mutant with a calcineurin-independent vacuolar Ca(2+)/H(+) exchanger activity, confers calcineurin-independent Mn(2+) tolerance in Saccharomyces cerevisiae
    Yunying Zhao
    a The State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi 214122, People s Republic of China
    Can J Microbiol 62:475-84. 2016
  6. pmc TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy
    Ariadne Vlahakis
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616
    Proc Natl Acad Sci U S A 111:10586-91. 2014
  7. doi ESCRT components regulate the expression of the ER/Golgi calcium pump gene PMR1 through the Rim101/Nrg1 pathway in budding yeast
    Yunying Zhao
    The State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi 214122, China
    J Mol Cell Biol 5:336-44. 2013
  8. pmc Orm proteins integrate multiple signals to maintain sphingolipid homeostasis
    Charulatha Gururaj
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 288:20453-63. 2013
  9. pmc Regulation of ceramide biosynthesis by TOR complex 2
    Sofia Aronova
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA 95616, USA
    Cell Metab 7:148-58. 2008
  10. pmc Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
    Brad J Niles
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:1536-41. 2012

Scientific Experts

  • Frank M Rusnak
  • Antonio Rodriguez
  • Olivier Cagnac
  • Yunying Zhao
  • Jose Ramos
  • Joaquin Arino
  • Ariadne Vlahakis
  • Ted Powers
  • Asier González
  • Amparo Ruiz
  • Dai Hirata
  • Tokichi Miyakawa
  • Huihui Xu
  • Linghuo Jiang
  • Atsunori Shitamukai
  • Charulatha Gururaj
  • Walter A Laviña
  • Brad J Niles
  • Rita T Ferreira
  • Maribel Marquina
  • Lina Barreto
  • Ryohei Tsubakiyama
  • Xiaoyan Wang
  • Jofre Ferrer-Dalmau
  • Aurélie Gardarin
  • Carlos Casado
  • Masaki Mizunuma
  • M Mizunuma
  • Sofia Aronova
  • Drew D Dudgeon
  • Yoshifumi Kobayashi
  • Shuliang Chen
  • M S Cyert
  • Jagoree Roy
  • Mitsuaki Tabuchi
  • Jose M Mulet
  • Shigeko Noma
  • Yan Zhang
  • T Miyakawa
  • D Hirata
  • Jodi Nunnari
  • Martin Graef
  • Amy Chang
  • Yoshinobu Kaneko
  • Minetaka Sugiyama
  • Bing Xiong
  • Ross Federman
  • Ross S Federman
  • Jingcai Du
  • Satoshi Harashima
  • - Hermansyah
  • Liliana Batista-Nascimento
  • Ana R Courelas Silva
  • Catarina Pimentel
  • Huzefa Mogri
  • O Erez
  • Claudina Rodrigues-Pousada
  • Ivan Munoz
  • Samuel Gelis
  • Mari Carmen Alvarez
  • Andrew Hill
  • Regina A Menezes
  • Mark A Sheff
  • Kazunori Kume
  • David M Simpson
  • Anri Gengyo
  • Elaine A Elion
  • Josuke Yamamoto
  • María del Carmen Ruiz
  • Jorge Perez-Valle
  • Stéphane Chédin
  • Emmanuel Godat
  • Maria Platara
  • Gilles Lagniel
  • Jean Labarre
  • T J Kingsbury
  • Lynne Yenush
  • Raquel Serrano
  • Patrice Catty
  • Clara Navarrete
  • Jean Christophe Aude
  • Jose L Martinez
  • Carmen Melero
  • Antonio Casamayor
  • K W Cunningham
  • Patricia M Kane
  • Maureen Tarsio
  • B Jiang
  • Ichitaro Okada
  • Tomomi Inai

Detail Information

Publications45

  1. pmc Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
    A M Stathopoulos
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Genes Dev 11:3432-44. 1997
    ..Thus, in response to multiple signals, calcineurin acts through the Crz1p transcription factor to differentially regulate the expression of several target genes in yeast...
  2. pmc Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin
    C Zhao
    Department of Biochemistry, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 18:1013-22. 1998
    ..Therefore, a double mutant in calcineurin (CNB1) and FKS1 is inviable due to a deficiency in FKS2 expression...
  3. pmc Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90 and inhibited by calcineurin and Cmk2 in response to endoplasmic reticulum stresses
    Drew D Dudgeon
    Department of Biology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Eukaryot Cell 7:2037-51. 2008
    ..These findings reveal a novel prodeath role for Hsp90 and antideath roles for calcineurin and Cmk2 that extend the life span of S. cerevisiae cells responding to both natural and clinical antifungal compounds...
  4. ncbi Identification of a novel region critical for calcineurin function in vivo and in vitro
    B Jiang
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    J Biol Chem 274:18543-51. 1999
    ....
  5. doi Vcx1-D1 (M383I), the Vcx1 mutant with a calcineurin-independent vacuolar Ca(2+)/H(+) exchanger activity, confers calcineurin-independent Mn(2+) tolerance in Saccharomyces cerevisiae
    Yunying Zhao
    a The State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi 214122, People s Republic of China
    Can J Microbiol 62:475-84. 2016
    ....
  6. pmc TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy
    Ariadne Vlahakis
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616
    Proc Natl Acad Sci U S A 111:10586-91. 2014
    ..Our work reveals that the TORC2 pathway regulates autophagy in an opposing manner to TORC1 to provide a tunable response to cellular metabolic status. ..
  7. doi ESCRT components regulate the expression of the ER/Golgi calcium pump gene PMR1 through the Rim101/Nrg1 pathway in budding yeast
    Yunying Zhao
    The State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi 214122, China
    J Mol Cell Biol 5:336-44. 2013
    ..Collectively, these data have uncovered a function of ESCRT components in regulating PMR1 expression through the Nrg1/Rim101 pathway. Our findings provide important clues for understanding human diseases related to calcium homeostasis. ..
  8. pmc Orm proteins integrate multiple signals to maintain sphingolipid homeostasis
    Charulatha Gururaj
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 288:20453-63. 2013
    ..Conversely, the calcium- and calcineurin-dependent pathway signals ER stress response upon lipid dysregulation in the absence of the Orm proteins to restore ER homeostasis. ..
  9. pmc Regulation of ceramide biosynthesis by TOR complex 2
    Sofia Aronova
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA 95616, USA
    Cell Metab 7:148-58. 2008
    ..Because Ypk2 is activated independently by LCBs, the direct precursors to ceramides, our data suggest a model wherein TORC2 signaling is coupled with LCB levels to control Ypk2 activity and, ultimately, regulate ceramide formation...
  10. pmc Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
    Brad J Niles
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:1536-41. 2012
    ..These findings both extend the scope of cellular processes regulated by Ypk1/2 to include negative regulation of calcineurin and broaden the repertoire of mechanisms for membrane recruitment and activation of a protein kinase...
  11. pmc Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene
    Xiaoyan Wang
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    BMC Mol Biol 12:51. 2011
    ..The major signal transduction pathways that activate transcription of the FKS2 gene include the cell wall integrity and calcineurin pathways, and the Ste11p pathway...
  12. pmc Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin
    Maribel Marquina
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Genetics 190:1355-64. 2012
    ..Deletion of CNB1, encoding the regulatory subunit of the calcineurin phosphatase, blocked Ypi1-induced expression of ENA1, ..
  13. doi Arsenic stress elicits cytosolic Ca(2+) bursts and Crz1 activation in Saccharomyces cerevisiae
    Rita T Ferreira
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    Microbiology 158:2293-302. 2012
    ..and translocated to the nucleus, and stimulates CDRE-driven expression of the lacZ reporter gene in a Cnb1-dependent manner...
  14. doi Functionally redundant protein phosphatase genes PTP2 and MSG5 co-regulate the calcium signaling pathway in Saccharomyces cerevisiae upon exposure to high extracellular calcium concentration
    Walter A Laviña
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biosci Bioeng 115:138-46. 2013
    ..this paper, we found that the inactivation of calcineurin by the disruption of the calcineurin regulatory subunit, CNB1 or treatment with a calcineurin inhibitor, FK506, can suppress the calcium-sensitive phenotype of the ptp2Δmsg5Δ ..
  15. ncbi Role of protein phosphatases 2C on tolerance to lithium toxicity in the yeast Saccharomyces cerevisiae
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Mol Microbiol 62:263-77. 2006
    ..These results indicate that Ptc1p modulates the function of Ena1p by regulating the Hal3/Ppz1,2 pathway. In conclusion, overexpression of PTC3 and lack of PTC1 affect lithium tolerance in yeast, although through different mechanisms...
  16. pmc Implication of Ca2+ in the regulation of replicative life span of budding yeast
    Ryohei Tsubakiyama
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi Hiroshima 739 8530, Japan
    J Biol Chem 286:28681-7. 2011
    ..Thus, our results indicate that Ca(2+) homeostasis/Ca(2+) signaling are required to regulate longevity in budding yeast...
  17. pmc Vacuolar cation/H+ antiporters of Saccharomyces cerevisiae
    Olivier Cagnac
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Apartado 419, E 18080 Granada, Spain
    J Biol Chem 285:33914-22. 2010
    ..The relative importance of Nhx1p, Vnx1p, and Vcx1p in the vacuolar accumulation of monovalent cations will be discussed...
  18. doi Endoplasmic reticulum is a major target of cadmium toxicity in yeast
    Aurélie Gardarin
    Equipe Transports et Régulations Intracellulaires de Métaux, LCBM iRTSV, CEA Grenoble, 17 rue des Martyrs, F 38054 Grenoble Cedex 9, France
    Mol Microbiol 76:1034-48. 2010
    ..In particular, Cd(2+) activates the calcium channel Cch1/Mid1, which also contributes to Cd(2+) entry into the cell. The results reinforce the interest of using yeast as a cellular model to study toxicity mechanisms in eukaryotic cells...
  19. doi Regulation of Trk-dependent potassium transport by the calcineurin pathway involves the Hal5 kinase
    Carlos Casado
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    FEBS Lett 584:2415-20. 2010
    ..However, the growth defect of cnb1 cells at K(+)-limiting conditions can be rescued in part by overexpression of HAL5, and this mutation further ..
  20. doi Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis
    Jofre Ferrer-Dalmau
    Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Barcelona 08193, Spain
    Biochem J 426:355-64. 2010
    ..Remarkably, the evidence collected indicates that the role of Ref2 in cation homoeostasis may be unrelated to its previously identified function in the formation of mRNA via the APT (for associated with Pta1) complex...
  21. pmc A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants
    Antonio Rodriguez
    Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Mol Cell 33:616-26. 2009
    ..These studies suggest that LxVP-type sites are a common feature of calcineurin substrates, and that immunosuppressant-immunophilin complexes inhibit calcineurin by interfering with this mode of substrate recognition...
  22. pmc Cardiolipin mediates cross-talk between mitochondria and the vacuole
    Shuliang Chen
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Mol Biol Cell 19:5047-58. 2008
    ..Our results demonstrate the existence of a novel mitochondria-vacuole signaling pathway mediated by CL synthesis...
  23. doi Identification of Tup1 and Cyc8 mutations defective in the responses to osmotic stress
    Yoshifumi Kobayashi
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1 3 1 Kagamiyama, Higashi Hiroshima 739 8530, Japan
    Biochem Biophys Res Commun 368:50-5. 2008
    ....
  24. pmc The Saccharomyces cerevisiae RanGTP-binding protein msn5p is involved in different signal transduction pathways
    P M Alepuz
    Departamento de Bioquímica y Biología Molecular Universitat de Valencia and Instituto de Agroquímica y Tecnología de Alimentos CSIC, 46100 Burjassot Valencia, Spain
    Genetics 153:1219-31. 1999
    ..Therefore, Msn5p could be a receptor for several proteins involved in different signaling pathways...
  25. ncbi Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae
    S A Parent
    Merck Research Laboratories, Rahway, NJ 07065
    J Gen Microbiol 139:2973-84. 1993
    ..two genes (CNA1 and CNA2) encoding the alternative forms of the catalytic A subunit of calcineurin, or of the gene (CNB1) encoding the regulatory B subunit, is lethal in an fks1 mutant...
  26. ncbi The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth
    W K Eng
    Department of Biomolecular Disovery, SmithKline Beecham Pharmaceuticals King of Prussia, PA 19406
    Gene 151:61-71. 1994
    ..These data suggest that FKS1 provides a unique cellular function which, when absent, increases FK506 and CsA sensitivity by making the CNs (or a CN-dependent function) essential...
  27. ncbi Cooperation of calcineurin and vacuolar H(+)-ATPase in intracellular Ca2+ homeostasis of yeast cells
    I Tanida
    Department of Plant Sciences, Graduate School of Science, University of Tokyo, Japan
    J Biol Chem 270:10113-9. 1995
    ..their binding proteins and ascribable to inhibition of calcineurin activity; a mutation of a calcineurin subunit (cnb1) shows synthetic lethal interaction with the vma mutation...
  28. ncbi Genetic evidence for the functional redundancy of the calcineurin- and Mpk1-mediated pathways in the regulation of cellular events important for growth in Saccharomyces cerevisiae
    T Nakamura
    Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Higashi Hiroshima, Japan
    Mol Gen Genet 251:211-9. 1996
    ..The mutants were classified into four complementation groups (crv1,2,3 and 4). Crv1 was allelic to cnb1, a mutation in the regulatory subunit of calcineurin...
  29. ncbi Activated calcineurin confers high tolerance to ion stress and alters the budding pattern and cell morphology of yeast cells
    I Mendoza
    Instituto de Recursos Naturales y Agrobiologia, Consejo Superior de Investigaciones Cientificas, P O Box 1052, Sevilla 41080, Spain
    J Biol Chem 271:23061-7. 1996
    ..These results suggest that calcineurin may also act in the establishment of cell polarity...
  30. ncbi Mechanisms of salt tolerance conferred by overexpression of the HAL1 gene in Saccharomyces cerevisiae
    G Rios
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia CSIC, Spain
    Yeast 13:515-28. 1997
    ..As a consequence, osmotic adjustment through glycerolsynthesis, a process not affected by HAL1, is the limiting factor for growth on galactose under NaCl stressed...
  31. ncbi Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast
    M Mizunuma
    Department of Molecular Biotechnology, Graduate School of Engineering, Hiroshima University, Higashi Hiroshima, Japan
    Nature 392:303-6. 1998
    ..These cellular pathways also induce a G2-phase delay in response to hypotonic shock...
  32. pmc Ion tolerance of Saccharomyces cerevisiae lacking the Ca2+/CaM-dependent phosphatase (calcineurin) is improved by mutations in URE2 or PMA1
    J L Withee
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Genetics 149:865-78. 1998
    ..These studies further characterize the roles that URE2 and PMA1 play in regulating intracellular ion homeostasis...
  33. pmc Identification of a calcineurin-independent pathway required for sodium ion stress response in Saccharomyces cerevisiae
    R W Ganster
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Genetics 150:31-42. 1998
    ..Taken together, our data demonstrate that response to ion stress requires the participation of both calcineurin-dependent and -independent pathways...
  34. ncbi Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae
    C S Hemenway
    Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Mol Gen Genet 261:388-401. 1999
    ..Taken together, our findings support a model in which calcineurin and Lic4 are components of signalling cascades that regulate cation stress responses in yeast...
  35. pmc A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function
    Jagoree Roy
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA
    Mol Cell 25:889-901. 2007
    ..Thus, calcineurin-substrate affinity determines the Ca(2+) concentration dependence and output of signaling in vivo as well as the balance between different branches of calcineurin signaling in an overall biological response...
  36. pmc A conserved family of calcineurin regulators
    T J Kingsbury
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Genes Dev 14:1595-604. 2000
    ....
  37. ncbi Calcineurin: form and function
    F Rusnak
    Section of Hematology Research and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Physiol Rev 80:1483-521. 2000
    ..This review provides a comprehensive examination of the biological roles of calcineurin and reviews aspects related to its structure and catalytic mechanism...
  38. pmc Screening for modulators of spermine tolerance identifies Sky1, the SR protein kinase of Saccharomyces cerevisiae, as a regulator of polyamine transport and ion homeostasis
    O Erez
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 21:175-84. 2001
    ..While deletion or overexpression of SKY1 did not significantly affect Pma1p activity, the ability of overexpressed Sky1p, Ptk1p, and Ptk2p to increase sensitivity to LiCl depends on the integrity of PPZ1 but not of ENA1...
  39. pmc GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast
    M Mizunuma
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi Hiroshima 739 8526, Japan
    EMBO J 20:1074-85. 2001
    ..The Ca2+-activated pathway may play a role in the rapid inactivation of Hsl1 at the cell cycle stage(s) when APC activity is low...
  40. ncbi Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiae
    Atsunori Shitamukai
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi Hiroshima 739 8530, Japan
    J Biol Chem 279:3651-61. 2004
    ..redundant function(s) in the events essential for growth, the simultaneous deletion of both these pathways (Delta cnb1 Delta mpk1) leads to lethality...
  41. pmc Polarized morphogenesis regulator Spa2 is required for the function of putative stretch-activated Ca2+-permeable channel component Mid1 in Saccharomyces cerevisiae
    Shigeko Noma
    Department of Biology, Tokyo Gakugei University, Tokyo 184 8501, Japan
    Eukaryot Cell 4:1353-63. 2005
    ..Therefore, we suggest that Mid1 function is influenced by Spa2 function through polarized morphogenesis...
  42. pmc The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation
    Mitsuaki Tabuchi
    Department of Cellular and Molecular Medicine and Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0668, USA
    Mol Cell Biol 26:5861-75. 2006
    ..Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization...
  43. pmc Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone
    M S Cyert
    Department of Molecular and Cell Biology, University of California 94720
    Mol Cell Biol 12:3460-9. 1992
    ..These antibodies were used to isolate the structural gene (CNB1) encoding this protein from a yeast expression library in the vector lambda gt11...
  44. ncbi Mutual antagonism of target of rapamycin and calcineurin signaling
    Jose M Mulet
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 281:33000-7. 2006
    ..Thus, TORC2-SLM signaling negatively regulates calcineurin, and calcineurin negatively regulates TORC2-SLM. These findings provide a molecular basis for the mutual antagonism of growth and stress...