CLN3

Summary

Gene Symbol: CLN3
Description: cyclin CLN3
Alias: DAF1, FUN10, WHI1, cyclin CLN3
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Jeoung D, Oehlen L, Cross F. Cln3-associated kinase activity in Saccharomyces cerevisiae is regulated by the mating factor pathway. Mol Cell Biol. 1998;18:433-41 pubmed
    ..Genetic evidence has suggested that the G1 cyclins Cln1, Cln2, and Cln3 are targets of this pathway whose inhibition results in G1 arrest...
  2. Han B, Aramayo R, Polymenis M. The G1 cyclin Cln3p controls vacuolar biogenesis in Saccharomyces cerevisiae. Genetics. 2003;165:467-76 pubmed
    ..Third, vacuolar segregation was perturbed in cln3delta cells. Our findings reveal a novel role for a eukaryotic G(1) cyclin in cytoplasmic organelle biogenesis and segregation. ..
  3. Miller M, Cross F. Distinct subcellular localization patterns contribute to functional specificity of the Cln2 and Cln3 cyclins of Saccharomyces cerevisiae. Mol Cell Biol. 2000;20:542-55 pubmed
    ..The data presented here support the idea that cyclin function is regulated at the level of subcellular localization and that subcellular localization contributes to the functional specificity of Cln2p and Cln3p. ..
  4. Edgington N, Futcher B. Relationship between the function and the location of G1 cyclins in S. cerevisiae. J Cell Sci. 2001;114:4599-611 pubmed
    ..In addition, one function apparently required shuttling between the two compartments. The G1 cyclin Cln3 required nuclear localization...
  5. Cross F. Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating-pheromone signalling pathway. Mol Cell Biol. 1990;10:6482-90 pubmed
    ..In cln1 cln2 cln3 strains bearing plasmids containing the CLN3 (also called WHI1 or DAF1) coding sequence under the transcriptional control of a galactose-regulated promoter, shift from galactose ..
  6. Martin Yken H, Dagkessamanskaia A, Talibi D, Francois J. KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2, a gene involved in cell cycle progression in Saccharomyces cerevisiae. Curr Genet. 2002;41:323-32 pubmed
    ..that KNR4 is a member of the PKC1 pathway and genetically interacts with BCK2, a gene involved together with Cln3-Cdc28 in the G1 to S transition phase of the cell cycle, was as follows...
  7. Fernandez Sarabia M, Sutton A, Zhong T, Arndt K. SIT4 protein phosphatase is required for the normal accumulation of SWI4, CLN1, CLN2, and HCS26 RNAs during late G1. Genes Dev. 1992;6:2417-28 pubmed
    ..Strains containing mutations in SIT4 are sensitive to the loss of either CLN2 or CLN3 function...
  8. Skotheim J, Di Talia S, Siggia E, Cross F. Positive feedback of G1 cyclins ensures coherent cell cycle entry. Nature. 2008;454:291-6 pubmed publisher
    ..A similar G1/S regulatory network in mammalian cells, comprised of non-orthologous genes, suggests either conservation of regulatory architecture or convergent evolution. ..
  9. Costanzo M, Nishikawa J, Tang X, Millman J, Schub O, Breitkreuz K, et al. CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Cell. 2004;117:899-913 pubmed
    ..Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription. These findings harmonize G1/S control in eukaryotes. ..

More Information

Publications72

  1. Wijnen H, Futcher B. Genetic analysis of the shared role of CLN3 and BCK2 at the G(1)-S transition in Saccharomyces cerevisiae. Genetics. 1999;153:1131-43 pubmed
    ..Activation of SBF and MBF depends on the G(1) cyclin Cln3 and a largely uncharacterized protein called Bck2...
  2. Wang H, Carey L, Cai Y, Wijnen H, Futcher B. Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets. PLoS Biol. 2009;7:e1000189 pubmed publisher
    In yeast, the G1 cyclin Cln3 promotes cell cycle entry by activating the transcription factor SBF. In mammals, there is a parallel system for cell cycle entry in which cyclin dependent kinase (CDK) activates transcription factor E2F/Dp...
  3. Wijnen H, Landman A, Futcher B. The G(1) cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6. Mol Cell Biol. 2002;22:4402-18 pubmed
    In Saccharomyces cerevisiae (budding yeast), commitment to cell division in late G(1) is promoted by the G(1) cyclin Cln3 and its associated cyclin-dependent kinase, Cdc28...
  4. Vergés E, Colomina N, Garí E, Gallego C, Aldea M. Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry. Mol Cell. 2007;26:649-62 pubmed
    G1 cyclin Cln3 plays a key role in linking cell growth and proliferation in budding yeast...
  5. de Bruin R, McDonald W, Kalashnikova T, Yates J, Wittenberg C. Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5. Cell. 2004;117:887-98 pubmed
    G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle...
  6. Nash R, Volpe T, Futcher B. Isolation and characterization of WHI3, a size-control gene of Saccharomyces cerevisiae. Genetics. 2001;157:1469-80 pubmed
    ..b>CLN3-1 whi3 cells are extremely small, nearly sterile, and largely nonresponsive to mating factor...
  7. Cross F, Blake C. The yeast Cln3 protein is an unstable activator of Cdc28. Mol Cell Biol. 1993;13:3266-71 pubmed
    The Cln3 cyclin homolog of Saccharomyces cerevisiae functions to promote cell cycle START for only a short time following its synthesis. Cln3 protein is highly unstable and is stabilized by C-terminal truncation...
  8. Huang D, Kaluarachchi S, van Dyk D, Friesen H, Sopko R, Ye W, et al. Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. PLoS Biol. 2009;7:e1000188 pubmed publisher
    ..Phosphorylation and removal of Whi5 by the cyclin-dependent kinase (CDK) Cln3-Cdc28 alleviates the Whi5-dependent repression on SBF and MBF, initiating entry into a new cell cycle...
  9. Mizunuma M, Tsubakiyama R, Ogawa T, Shitamukai A, Kobayashi Y, Inai T, et al. Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast. J Biol Chem. 2013;288:10558-66 pubmed publisher
    ..Phosphorylation of Whi3 by PKA led to its decreased interaction with CLN3 G1 cyclin mRNA and was required for the promotion of G1/S progression...
  10. Manukyan A, Zhang J, Thippeswamy U, Yang J, Zavala N, Mudannayake M, et al. Ccr4 alters cell size in yeast by modulating the timing of CLN1 and CLN2 expression. Genetics. 2008;179:345-57 pubmed publisher
    ..Overexpression of CLN1, CLN2, CLN3, and SWI4 reduces the size of ccr4 delta cells, suggesting that ccr4 delta cells have a G(1)-phase cyclin ..
  11. Tyers M, Futcher B. Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes. Mol Cell Biol. 1993;13:5659-69 pubmed
    ..We have studied the kinase complexes formed between Cdc28 and each of the G1 cyclins Cln1, Cln2, and Cln3. Each complex has a specific array of coprecipitated in vitro substrates...
  12. Yaglom J, Goldberg A, Finley D, Sherman M. The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol Cell Biol. 1996;16:3679-84 pubmed
    The G1 cyclin Cln3 of the yeast Saccharomyces cerevisiae is rapidly degraded by the ubiquitin-proteasome pathway. This process is triggered by p34CDC28-dependent phosphorylation of Cln3...
  13. Wang H, Garí E, Vergés E, Gallego C, Aldea M. Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin-Cdk complex to late G1. EMBO J. 2004;23:180-90 pubmed
    The G1 cyclin Cln3 is a key activator of cell-cycle entry in budding yeast. Here we show that Whi3, a negative G1 regulator of Cln3, interacts in vivo with the cyclin-dependent kinase Cdc28 and regulates its localization in the cell...
  14. Ho Y, Costanzo M, Moore L, Kobayashi R, Andrews B. Regulation of transcription at the Saccharomyces cerevisiae start transition by Stb1, a Swi6-binding protein. Mol Cell Biol. 1999;19:5267-78 pubmed
    ..In vivo accumulation of Stb1 phosphoforms was dependent on CLN1, CLN2, and CLN3, which encode G(1)-specific cyclins for the cyclin-dependent kinase Cdc28, and Stb1 was phosphorylated by Cln-Cdc28 ..
  15. Miller M, Cross F. Mechanisms controlling subcellular localization of the G(1) cyclins Cln2p and Cln3p in budding yeast. Mol Cell Biol. 2001;21:6292-311 pubmed
  16. Tyers M, Tokiwa G, Futcher B. Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 1993;12:1955-68 pubmed
    In the budding yeast Saccharomyces cerevisiae, the G1 cyclins Cln1, Cln2 and Cln3 regulate entry into the cell cycle (Start) by activating the Cdc28 protein kinase...
  17. Cross F. DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol Cell Biol. 1988;8:4675-84 pubmed
    ..A dominant mutation (DAF1-1) which causes both alpha-factor resistance and small cell size (volume about 0...
  18. Ferrezuelo F, Aldea M, Futcher B. Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast. Cell Cycle. 2009;8:239-52 pubmed
    ..Bck2 becomes essential in the absence of Cln3, the most upstream activator of this transcriptional program...
  19. Nash R, Tokiwa G, Anand S, Erickson K, Futcher A. The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog. EMBO J. 1988;7:4335-46 pubmed
    b>WHI1-1 is a dominant mutation that reduces cell volume by allowing cells to commit to division at abnormally small sizes, shortening the G1 phase of the cell cycle...
  20. Yaglom J, Linskens M, Sadis S, Rubin D, Futcher B, Finley D. p34Cdc28-mediated control of Cln3 cyclin degradation. Mol Cell Biol. 1995;15:731-41 pubmed
    b>Cln3 cyclin of the budding yeast Saccharomyces cerevisiae is a key regulator of Start, a cell cycle event in G1 phase at which cells become committed to division...
  21. Munoz I, Simon E, Casals N, Clotet J, Arino J. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast. 2003;20:157-69 pubmed
    ..The screening yielded several genes known to perform key roles in cell cycle events, such as CLN3, BCK2 or SWI4, thus proving its usefulness as a tool for this type of studies...
  22. Di Como C, Chang H, Arndt K. Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2. Mol Cell Biol. 1995;15:1835-46 pubmed
    The Saccharomyces cerevisiae CLN3 protein, a G1 cyclin, positively regulates the expression of CLN1 and CLN2, two additional G1 cyclins whose expression during late G1 is activated, in part, by the transcription factors SWI4 and SWI6...
  23. Epstein C, Cross F. Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START. Mol Cell Biol. 1994;14:2041-7 pubmed
    Cell cycle START in Saccharomyces cerevisiae requires at least one of the three CLN genes (CLN1, CLN2, or CLN3)...
  24. Tyers M, Tokiwa G, Nash R, Futcher B. The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J. 1992;11:1773-84 pubmed
    ..have been identified; these include the Cdc28 protein kinase and three cyclin-like proteins, Cln1, Cln2 and Cln3. We find that Cln3 is a very unstable, low abundance protein...
  25. Bastajian N, Friesen H, Andrews B. Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast. PLoS Genet. 2013;9:e1003507 pubmed publisher
    ..Overexpression of BCK2 decreases Yox1 localization to the early G1-specific CLN3 promoter and rescues the lethality caused by overexpression of YOX1...
  26. Di Talia S, Wang H, Skotheim J, Rosebrock A, Futcher B, Cross F. Daughter-specific transcription factors regulate cell size control in budding yeast. PLoS Biol. 2009;7:e1000221 pubmed publisher
    ..However, it has been proposed that daughter-specific, Ace2-dependent repression of expression of the G1 cyclin CLN3 had a dominant role in delaying daughters in G1...
  27. Yang J, Dungrawala H, Hua H, Manukyan A, Abraham L, Lane W, et al. Cell size and growth rate are major determinants of replicative lifespan. Cell Cycle. 2011;10:144-55 pubmed publisher
    ..Indeed, cumulative results revealed that life expectancy is size-dependent, and that the rate at which cells age is determined in large part by the amount of cell growth per generation. ..
  28. Elion E, Grisafi P, Fink G. FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation. Cell. 1990;60:649-64 pubmed
    ..The G1 arrest defect of these fus3 mutants is suppressed by a daf1/whi1 null mutation (also called cln3, a putative cyclin)...
  29. Cai Y, Futcher B. Effects of the yeast RNA-binding protein Whi3 on the half-life and abundance of CLN3 mRNA and other targets. PLoS ONE. 2013;8:e84630 pubmed publisher
    Whi3 is an RNA binding protein known to bind the mRNA of the yeast G1 cyclin gene CLN3. It inhibits CLN3 function, but the mechanism of this inhibition is unclear; in previous studies, Whi3 made no observable difference to CLN3 mRNA ..
  30. Sartorel E, Barrey E, Lau R, Thorner J. Plasma membrane aminoglycerolipid flippase function is required for signaling competence in the yeast mating pheromone response pathway. Mol Biol Cell. 2015;26:134-50 pubmed publisher
    ..Thus proper remodeling of plasma membrane aminoglycerolipids and phosphoinositides is necessary for efficient recruitment, stability, and function of the pheromone signaling apparatus. ..
  31. Ryu H, Wilson N, Mehta S, Hwang S, Hochstrasser M. Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes Dev. 2016;30:1881-94 pubmed publisher
    ..Importantly, increased dosage of two genes on ChrI-CLN3 and CCR4, encoding a G1-phase cyclin and a subunit of the Ccr4-Not deadenylase complex, respectively-suppresses ..
  32. Kõivomägi M, Ord M, Iofik A, Valk E, Venta R, Faustova I, et al. Multisite phosphorylation networks as signal processors for Cdk1. Nat Struct Mol Biol. 2013;20:1415-24 pubmed publisher
  33. Richardson H, Wittenberg C, Cross F, Reed S. An essential G1 function for cyclin-like proteins in yeast. Cell. 1989;59:1127-33 pubmed
    ..cerevisiae were found to share limited homology with cyclins. Mutational elimination of the CLN1, CLN2, and DAF1/WHI1 products leads to cell cycle arrest independent of cell type, while expression of any one of the genes allows ..
  34. Anthony C, Zong Q, De Benedetti A. Overexpression of eIF4E in Saccharomyces cerevisiae causes slow growth and decreased alpha-factor response through alterations in CLN3 expression. J Biol Chem. 2001;276:39645-52 pubmed
    ..Activation of Start is presumed to be triggered by a post-transcriptional increase in Cln3 during early G(1)...
  35. Pope P, Bhaduri S, Pryciak P. Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1. Curr Biol. 2014;24:1390-1396 pubmed publisher
    ..Our findings uncover a novel mechanism of Cdk regulation by external signals and shed new light on Far1 function to provide a revised view of cell-cycle arrest in this model system. ..
  36. Landry B, Doyle J, Toczyski D, Benanti J. F-box protein specificity for g1 cyclins is dictated by subcellular localization. PLoS Genet. 2012;8:e1002851 pubmed publisher
    ..The G1 cyclin Cln3 is a key regulator of cell size and cell cycle entry in budding yeast...
  37. Oomuro M, Kato T, Zhou Y, Watanabe D, Motoyama Y, Yamagishi H, et al. Defective quiescence entry promotes the fermentation performance of bottom-fermenting brewer's yeast. J Biosci Bioeng. 2016;122:577-582 pubmed publisher
    ..pastorianus Weihenstephan 34/70: a RIM15 gene disruptant that was defective in entry into G0; and a CLN3?PEST mutant, in which the G1 cyclin Cln3p accumulated at high levels...
  38. Pecani K, Cross F. Degradation of the Mitotic Cyclin Clb3 Is not Required for Mitotic Exit but Is Necessary for G1 Cyclin Control of the Succeeding Cell Cycle. Genetics. 2016;204:1479-1494 pubmed
  39. Talarek N, Gueydon E, Schwob E. Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast. elife. 2017;6: pubmed publisher
    ..Interestingly Cln3-Cdk1 also inhibits Rim15 activity, which enables homeostatic control of Whi5 phosphorylation and cell cycle entry...
  40. Sugimoto K, Matsumoto K, Kornberg R, Reed S, Wittenberg C. Dosage suppressors of the dominant G1 cyclin mutant CLN3-2: identification of a yeast gene encoding a putative RNA/ssDNA binding protein. Mol Gen Genet. 1995;248:712-8 pubmed
    Three G1 cyclins, CLN1, CLN2, and CLN3, have been identified in the budding yeast Saccharomyces cerevisiae. G1 cyclins are essential, albeit functionally redundant, rate-limiting activators of cell cycle initiation...
  41. Cherkasova V, Lyons D, Elion E. Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p. Genetics. 1999;151:989-1004 pubmed
    ..Fus3p and Kss1p together increase the expression of CLN3 and PCL2 genes that promote budding, and Kss1p inhibits the MAP kinase cascade...
  42. Levine K, Huang K, Cross F. Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificities. Mol Cell Biol. 1996;16:6794-803 pubmed
    ..redundant for cell cycle Start: any single CLN gene is sufficient to promote Start, while the cln1 cln2 cln3 triple mutant is Start defective and inviable...
  43. Alberghina L, Rossi R, Querin L, Wanke V, Vanoni M. A cell sizer network involving Cln3 and Far1 controls entrance into S phase in the mitotic cycle of budding yeast. J Cell Biol. 2004;167:433-43 pubmed
    ..b>Cln3 Delta, far1 Delta, and strains overexpressing Far1 do not delay budding during an ethanol glucose shift-up as wild ..
  44. Miles S, Li L, Davison J, Breeden L. Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state. PLoS Genet. 2013;9:e1003854 pubmed publisher
    ..Maintaining G1 arrest requires transcriptional repression of the G1 cyclin, CLN3, by Xbp1. Xbp1 is induced as glucose is depleted and it is among the most abundant transcripts in quiescent cells...
  45. Ydenberg C, Rose M. Antagonistic regulation of Fus2p nuclear localization by pheromone signaling and the cell cycle. J Cell Biol. 2009;184:409-22 pubmed publisher
    ..Our results indicate a novel mechanism by which pheromone-induced proteins are regulated during the transition from mitosis to conjugation. ..
  46. Horecka J, Sprague G. Identification and characterization of FAR3, a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae. Genetics. 1996;144:905-21 pubmed
    ..Several of these mutants identified previously known genes, including CLN3, FUS3, and FAR1. In addition, a new gene, FAR3, was identified and characterized...
  47. Bogomolnaya L, Pathak R, Guo J, Cham R, Aramayo R, Polymenis M. Hym1p affects cell cycle progression in Saccharomyces cerevisiae. Curr Genet. 2004;46:183-92 pubmed
    ..Genetic analysis of HYM1, ACE2 and CLN3 mutants suggests that these genes together contribute to the establishment of asynchronous mother-daughter cell ..
  48. Li X, Cai M. Recovery of the yeast cell cycle from heat shock-induced G(1) arrest involves a positive regulation of G(1) cyclin expression by the S phase cyclin Clb5. J Biol Chem. 1999;274:24220-31 pubmed
    ..Here we report our finding that the G(1) cyclin Cln3 and the S cyclin Clb5 are the key factors required for recovery from heat shock-induced G(1) arrest...
  49. Baumgartner B, Bennett M, Ferry M, Johnson T, Tsimring L, Hasty J. Antagonistic gene transcripts regulate adaptation to new growth environments. Proc Natl Acad Sci U S A. 2011;108:21087-92 pubmed publisher
    ..show that the advantage arises from relief of translational competition between GAL1 transcripts and those of cyclin CLN3, a translationally regulated initiator of cell division...
  50. Bhaduri S, Valk E, Winters M, Gruessner B, Loog M, Pryciak P. A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry. Curr Biol. 2015;25:316-25 pubmed publisher
    ..In budding yeast, the decision to begin a new cell cycle is regulated by three G1 cyclins (Cln1-Cln3)...
  51. Dungrawala H, Hua H, Wright J, Abraham L, Kasemsri T, McDowell A, et al. Identification of new cell size control genes in S. cerevisiae. Cell Div. 2012;7:24 pubmed publisher
    ..Further, the small (whi) mutants mrpl49? and cbs1? are dependent on CLN3 for cell size effects...
  52. Adames N, Schuck P, Chen K, Murali T, Tyson J, Peccoud J. Experimental testing of a new integrated model of the budding yeast Start transition. Mol Biol Cell. 2015;26:3966-84 pubmed publisher
    ..The new model incorporates Whi3 inhibition of Cln3 activity, Whi5 inhibition of SBF and MBF transcription factors, and feedback inhibition of Whi5 by G1-S cyclins...
  53. Willems A, Lanker S, Patton E, Craig K, Nason T, Mathias N, et al. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell. 1996;86:453-63 pubmed
    ..is initiated in late G1 phase once the Cdc28 cyclin-dependent kinase is activated by the G1 cyclins Cln1, Cln2, and Cln3. The extreme instability of the Cln proteins couples environmental signals, which regulate Cln synthesis, to cell ..
  54. Stephan O, Koch C. Sin3 is involved in cell size control at Start in Saccharomyces cerevisiae. FEBS J. 2009;276:3810-24 pubmed publisher
    ..We conclude that the Sin3/Rpd3 histone deacetylase complex helps to prevent premature activation of the S phase in daughter cells. ..
  55. Schneider B, Yang Q, Futcher A. Linkage of replication to start by the Cdk inhibitor Sic1. Science. 1996;272:560-2 pubmed
    ..the only nonredundant essential function of Clns, because a sic1 deletion rescued the inviability of the cln1 cln2 cln3 triple mutant. In sic1 mutants, DNA replication became uncoupled from budding...
  56. Laman H, Balderes D, Shore D. Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae. Mol Cell Biol. 1995;15:3608-17 pubmed
    ..Mutations in different cyclin genes (CLN3, CLB5, and CLB2) and two cell cycle transcriptional regulators (SWI4 and MBP1) also suppress the silencing defect ..
  57. Martin Yken H, Dagkessamanskaia A, de Groot P, Ram A, Klis F, Francois J. Saccharomyces cerevisiae YCRO17c/CWH43 encodes a putative sensor/transporter protein upstream of the BCK2 branch of the PKC1-dependent cell wall integrity pathway. Yeast. 2001;18:827-40 pubmed
    ..expression of genes encoding downstream proteins of the PKC1 pathway However, unlike BCK2, whose disruption in a cln3 mutant resulted in growth arrest in G(1), no growth defect was observed in a double cwh43 cln3 mutants...
  58. Miller M, Cross F, Groeger A, Jameson K. Identification of novel and conserved functional and structural elements of the G1 cyclin Cln3 important for interactions with the CDK Cdc28 in Saccharomyces cerevisiae. Yeast. 2005;22:1021-36 pubmed
    Regions of the budding yeast G1 cyclin Cln3 were characterized using mutational analysis and viability assays to identify functionally relevant and novel mutant alleles of CLN3...
  59. Goranov A, Cook M, Ricicova M, Ben Ari G, Gonzalez C, Hansen C, et al. The rate of cell growth is governed by cell cycle stage. Genes Dev. 2009;23:1408-22 pubmed publisher
    ..Our study uncovers a fundamental relationship whereby cell cycle position regulates growth. ..
  60. Irie K, Nomoto S, Miyajima I, Matsumoto K. SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae. Cell. 1991;65:785-95 pubmed
    ..However, GPA1Val50 cells do not recover from division arrest in the absence of both CLN1 and CLN3, which encode G1 cyclins, indicating that the recovery-promoting activity of GPA1Val50 requires the function of G1 ..
  61. Truman A, Kristjansdottir K, Wolfgeher D, Hasin N, Polier S, Zhang H, et al. CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression. Cell. 2012;151:1308-18 pubmed publisher
    ..T36 phosphorylation triggers displacement of Ydj1, allowing Ssa1 to bind the G1 cyclin Cln3 and promote its degradation...
  62. Palumbo P, Vanoni M, Cusimano V, Busti S, Marano F, Manes C, et al. Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate. Nat Commun. 2016;7:11372 pubmed publisher
    ..b>Cln3-Cdk1, whose nuclear amount is proportional to cell size, and then Cln1,2-Cdk1, randomly phosphorylate both decoy ..