Genomes and Genes
Gene Symbol: CIT1
Description: citrate (Si)-synthase CIT1
Alias: LYS6, citrate (Si)-synthase CIT1
Species: Saccharomyces cerevisiae S288c
- Lee Y, Jang J, Kim K, Maeng P. TCA cycle-independent acetate metabolism via the glyoxylate cycle in Saccharomyces cerevisiae. Yeast. 2011;28:153-66 pubmed publisherIn Saccharomyces cerevisiae, the accepted theory is that due to TCA cycle dysfunction, the ?cit1 mutant lacking the mitochondrial enzyme citrate synthase (Cit1) cannot grow on acetate, regardless of the presence of the peroxisomal ..
- Lee Y, Hoe K, Maeng P. Yeast cells lacking the CIT1-encoded mitochondrial citrate synthase are hypersusceptible to heat- or aging-induced apoptosis. Mol Biol Cell. 2007;18:3556-67 pubmed..cerevisiae, the initial reaction of the tricarboxylic acid cycle is catalyzed by the mitochondrial citrate synthase Cit1. The function of Cit1 has previously been studied mainly in terms of acetate utilization and metabolon construction...
- Graybill E, Rouhier M, Kirby C, Hawes J. Functional comparison of citrate synthase isoforms from S. cerevisiae. Arch Biochem Biophys. 2007;465:26-37 pubmed..gene has been identified as a dual specificity mitochondrial citrate and methylcitrate synthase and that of the CIT1 gene as a specific citrate synthase...
- Lee J, Cho S, Lee H, Lee C, Bae K, Maeng P. Identification of a cryptic N-terminal signal in Saccharomyces cerevisiae peroxisomal citrate synthase that functions in both peroxisomal and mitochondrial targeting. J Biochem. 2000;128:1059-72 pubmed..Both fusions, Cit1::Cit2 and Cit2::Cit1, complemented the glutamate auxotrophy caused by the double-disruption of the CIT1 and CIT2 ..
- McAlister Henn L, Small W. Molecular genetics of yeast TCA cycle isozymes. Prog Nucleic Acid Res Mol Biol. 1997;57:317-39 pubmed
- Small W, Brodeur R, Sandor A, Fedorova N, Li G, Butow R, et al. Enzymatic and metabolic studies on retrograde regulation mutants of yeast. Biochemistry. 1995;34:5569-76 pubmed
- Lee J, Lee Y, Lee C, Maeng P. Mutational and functional analysis of the cryptic N-terminal targeting signal for both mitochondria and peroxisomes in yeast peroxisomal citrate synthase Cit2p. J Biochem. 2006;140:121-33 pubmed..It is thus suggested that the potential of the N-terminal segment as an ambidextrous targeting signal can be unmasked by deletion of PTS1. ..
- Grandier Vazeille X, Bathany K, Chaignepain S, Camougrand N, Manon S, Schmitter J. Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Biochemistry. 2001;40:9758-69 pubmed..The association of these proteins is discussed in terms of NADH-channeling. ..
- Vélot C, Lebreton S, Morgunov I, Usher K, Srere P. Metabolic effects of mislocalized mitochondrial and peroxisomal citrate synthases in yeast Saccharomyces cerevisiae. Biochemistry. 1999;38:16195-204 pubmedGenes CIT1 and CIT2 from Saccharomyces cerevisiae encode mitochondrial and peroxisomal citrate synthases involved in the Krebs tricarboxylic acid (TCA) cycle and glyoxylate pathway, respectively...
- Beaufour M, Godin F, Vallee B, Cadene M, Bénédetti H. Interaction proteomics suggests a new role for the Tfs1 protein in yeast. J Proteome Res. 2012;11:3211-8 pubmed publisher..Integration of these results with known functional partners of Tfs1p shows that two subnetworks meet through the Tfs1p node, suggesting that it may act as a bridge between cell signaling and intermediate metabolism in yeast. ..
- Belenky P, Camacho D, Collins J. Fungicidal drugs induce a common oxidative-damage cellular death pathway. Cell Rep. 2013;3:350-8 pubmed publisher..Lastly, we demonstrate that DNA damage plays a critical role in antifungal-induced cellular death and that blocking DNA-repair mechanisms potentiates fungicidal activity. ..