Gene Symbol: CIN5
Description: Cin5p
Alias: HAL6, YAP4, Cin5p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Mendizabal I, Rios G, Mulet J, Serrano R, de Larrinoa I. Yeast putative transcription factors involved in salt tolerance. FEBS Lett. 1998;425:323-8 pubmed
    Four putative yeast transcription factors (Hal6-9p) have been identified which upon overexpression in multicopy plasmids increase sodium and lithium tolerance...
  2. Jackson T, Kwon E, Chachulska A, Hyman L. Novel roles for elongin C in yeast. Biochim Biophys Acta. 2000;1491:161-76 pubmed
    ..This suggests a novel role for Elongin C and provides insights into additional potential functions in mammalian cells. ..
  3. Furuchi T, Ishikawa H, Miura N, Ishizuka M, Kajiya K, Kuge S, et al. Two nuclear proteins, Cin5 and Ydr259c, confer resistance to cisplatin in Saccharomyces cerevisiae. Mol Pharmacol. 2001;59:470-4 pubmed
    ..We isolated two genes, CIN5 and YDR259c, that increased resistance to cisplatin when overexpressed in Saccharomyces cerevisiae...
  4. Delling U, Raymond M, Schurr E. Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugs. Antimicrob Agents Chemother. 1998;42:1034-41 pubmed
    ..Overexpression of the yeast genes CIN5 (a member of the family of bZIP transcription factors), STII (a Hsp90 cochaperone), and YOR273c (a member of the ..
  5. Fernandes L, Rodrigues Pousada C, Struhl K. Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol. 1997;17:6982-93 pubmed
    ..In addition, unlike other yap mutations tested, yap4 (cin5) mutations affect chromosome stability, and they suppress the cold-sensitive phenotype of yap1 mutant strains...
  6. Zakrzewska A, Boorsma A, Brul S, Hellingwerf K, Klis F. Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan. Eukaryot Cell. 2005;4:703-15 pubmed
    ..The first was a rapid and stable Cin5p-mediated response. Cin5p/Yap4p is a transcription factor involved in various stress responses...
  7. Fordyce P, Gerber D, Tran D, Zheng J, Li H, Derisi J, et al. De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis. Nat Biotechnol. 2010;28:970-5 pubmed publisher
    ..We expect that these data and future use of this technique will provide information essential for understanding transcription factor specificity, improving identification of regulatory sites and reconstructing regulatory interactions. ..
  8. Pereira J, Pimentel C, Amaral C, Menezes R, Rodrigues Pousada C. Yap4 PKA- and GSK3-dependent phosphorylation affects its stability but not its nuclear localization. Yeast. 2009;26:641-53 pubmed publisher
    b>Yap4 is a nuclear-resident transcription factor induced in Saccharomyces cerevisiae when exposed to several stress conditions, which include mild hyperosmotic and oxidative stress, temperature shift or metal exposure...
  9. Basmaji F, Martin Yken H, Durand F, Dagkessamanskaia A, Pichereaux C, Rossignol M, et al. The 'interactome' of the Knr4/Smi1, a protein implicated in coordinating cell wall synthesis with bud emergence in Saccharomyces cerevisiae. Mol Genet Genomics. 2006;275:217-30 pubmed

More Information


  1. Fu J, Hou J, Chen L, Wang M, Shen Y, Zhang Z, et al. The yeast BDF1 regulates endocytosis via LSP1 under salt stress. Curr Microbiol. 2015;70:671-8 pubmed publisher
    ..The results revealed that LSP1, an upstream component of endocytosis pathway, and CIN5, a transcription factor that mediates cellular resistance to stresses, can enhance salt resistance of bdf1∆...
  2. Gulshan K, Thommandru B, Moye Rowley W. Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4. J Biol Chem. 2012;287:26796-805 pubmed publisher
    ..These data uncover a new, conserved pathway for regulation of the oxidative stress response that serves to temporally limit the duration of Yap1-dependent transcriptional activation. ..
  3. Hanlon S, Rizzo J, Tatomer D, Lieb J, Buck M. The stress response factors Yap6, Cin5, Phd1, and Skn7 direct targeting of the conserved co-repressor Tup1-Ssn6 in S. cerevisiae. PLoS ONE. 2011;6:e19060 pubmed publisher
    ..Four top candidates, Cin5, Skn7, Phd1, and Yap6, all known to be associated with stress response gene regulation, were experimentally ..
  4. Sollner S, Schober M, Wagner A, Prem A, Lorkova L, Palfey B, et al. Quinone reductase acts as a redox switch of the 20S yeast proteasome. EMBO Rep. 2009;10:65-70 pubmed publisher
    ..of the FMN cofactor by either NADH or light irradiation results in the binding of the b-Zip transcription factor Yap4 to the Lot6-proteasome complex, indicating that recruitment of the transcription factor depends on the redox state ..
  5. Lacefield S, Magendantz M, Solomon F. Consequences of defective tubulin folding on heterodimer levels, mitosis and spindle morphology in Saccharomyces cerevisiae. Genetics. 2006;173:635-46 pubmed
  6. Nevitt T, Pereira J, Azevedo D, Guerreiro P, Rodrigues Pousada C. Expression of YAP4 in Saccharomyces cerevisiae under osmotic stress. Biochem J. 2004;379:367-74 pubmed
    b>YAP4, a member of the yeast activator protein ( YAP ) gene family, is induced in response to osmotic shock in the yeast Saccharomyces cerevisiae. The null mutant displays mild and moderate growth sensitivity at 0.4 M and 0...
  7. Dagkessamanskaia A, Martin Yken H, Basmaji F, Briza P, Francois J. Interaction of Knr4 protein, a protein involved in cell wall synthesis, with tyrosine tRNA synthetase encoded by TYS1 in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2001;200:53-8 pubmed
    ..Altogether, these data provide novel functions of Knr4p and Tys1p to those that were known before. ..
  8. Wang Z, Danziger S, Heavner B, Ma S, Smith J, Li S, et al. Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast. PLoS Comput Biol. 2017;13:e1005489 pubmed publisher
    ..With experimental validation, these novel genetic interactions involving the pyruvate dehydrogenase complex suggested a new role for fatty acid-responsive factor Oaf1 in regulating acetyl-CoA production in glucose grown cells. ..