Gene Symbol: CIA1
Description: iron-sulfur cluster assembly protein CIA1
Alias: iron-sulfur cluster assembly protein CIA1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Balk J, Aguilar Netz D, Tepper K, Pierik A, Lill R. The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Mol Cell Biol. 2005;25:10833-41 pubmed
    ..Here, we have identified and functionally characterized a novel WD40 repeat protein, designated Cia1, as an essential component required for Fe/S cluster assembly in vivo on cytosolic and nuclear, but not ..
  2. Srinivasan V, Netz D, Webert H, Mascarenhas J, Pierik A, Michel H, et al. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Structure. 2007;15:1246-57 pubmed
    The WD40-repeat protein Cia1 is an essential, conserved member of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery in eukaryotes. Here, we report the crystal structure of Saccharomyces cerevisiae Cia1 to 1.7 A resolution...
  3. Grether M, Herskowitz I. Genetic and biochemical characterization of the yeast spo12 protein. Mol Biol Cell. 1999;10:3689-703 pubmed
    ..We observed that a spo12 mutation is synthetically lethal in vegetative cells with a mutation in HCT1, a gene necessary for cells to exit mitosis, suggesting that Spo12p may have a role in exit from mitosis. ..
  4. Endo H, Kawashima S, Sato L, Lai M, Enomoto T, Seki M, et al. Chromatin dynamics mediated by histone modifiers and histone chaperones in postreplicative recombination. Genes Cells. 2010;15:945-58 pubmed publisher
    ..Here, histone H3 Lys56 acetylation, mediated by the histone acetyltransferase Rtt109 and the histone chaperone Cia1/Asf1, is shown to be required for postreplicative sister chromatid recombination...
  5. Padmanabhan B, Kataoka K, Umehara T, Adachi N, Yokoyama S, Horikoshi M. Structural similarity between histone chaperone Cia1p/Asf1p and DNA-binding protein NF-kappaB. J Biochem. 2005;138:821-9 pubmed
  6. Huang B, Lu J, Byström A. A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. RNA. 2008;14:2183-94 pubmed publisher
    ..Like the absence of the mcm(5) side chain, the lack of the s(2) group renders tRNA(mcm5s2UUC Glu) less sensitive to gamma-toxin, reinforcing the importance of the wobble nucleoside mcm(5)s(2)U for tRNA cleavage by gamma-toxin. ..