Gene Symbol: CIA1
Description: iron-sulfur cluster assembly protein CIA1
Alias: iron-sulfur cluster assembly protein CIA1
Species: Saccharomyces cerevisiae S288c
Balk J, Aguilar Netz D, Tepper K, Pierik A, Lill R. The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Mol Cell Biol. 2005;25:10833-41 pubmed
..Here, we have identified and functionally characterized a novel WD40 repeat protein, designated Cia1, as an essential component required for Fe/S cluster assembly in vivo on cytosolic and nuclear, but not ..
Srinivasan V, Netz D, Webert H, Mascarenhas J, Pierik A, Michel H, et al
. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Structure. 2007;15:1246-57 pubmed
The WD40-repeat protein Cia1 is an essential, conserved member of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery in eukaryotes. Here, we report the crystal structure of Saccharomyces cerevisiae Cia1 to 1.7 A resolution...
Grether M, Herskowitz I. Genetic and biochemical characterization of the yeast spo12 protein. Mol Biol Cell. 1999;10:3689-703 pubmed
..We observed that a spo12 mutation is synthetically lethal in vegetative cells with a mutation in HCT1, a gene necessary for cells to exit mitosis, suggesting that Spo12p may have a role in exit from mitosis. ..
Endo H, Kawashima S, Sato L, Lai M, Enomoto T, Seki M, et al
. Chromatin dynamics mediated by histone modifiers and histone chaperones in postreplicative recombination. Genes Cells. 2010;15:945-58 pubmed publisher
..Here, histone H3 Lys56 acetylation, mediated by the histone acetyltransferase Rtt109 and the histone chaperone Cia1/Asf1, is shown to be required for postreplicative sister chromatid recombination...
Padmanabhan B, Kataoka K, Umehara T, Adachi N, Yokoyama S, Horikoshi M. Structural similarity between histone chaperone Cia1p/Asf1p and DNA-binding protein NF-kappaB. J Biochem. 2005;138:821-9 pubmed
Huang B, Lu J, Byström A. A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. RNA. 2008;14:2183-94 pubmed publisher
..Like the absence of the mcm(5) side chain, the lack of the s(2) group renders tRNA(mcm5s2UUC Glu) less sensitive to gamma-toxin, reinforcing the importance of the wobble nucleoside mcm(5)s(2)U for tRNA cleavage by gamma-toxin. ..