Gene Symbol: CHA1
Description: L-serine/L-threonine ammonia-lyase CHA1
Alias: L-serine/L-threonine ammonia-lyase CHA1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Grauslund M, Didion T, Kielland Brandt M, Andersen H. BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiae. Biochim Biophys Acta. 1995;1269:275-80 pubmed
    To select the gene coding for an isoleucine permease, an isoleucine dependent strain (ilv1 cha1) was transformed with a yeast genomic multicopy library, and colonies growing at a low isoleucine concentration were selected...
  2. Montefusco D, Newcomb B, Gandy J, Brice S, Matmati N, Cowart L, et al. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. J Biol Chem. 2012;287:9280-9 pubmed publisher
    ..One of these heat-induced genes is the serine deamidase/dehydratase Cha1 known to be regulated by increased serine availability...
  3. Ramos F, Wiame J. Occurrence of a catabolic L-serine (L-threonine) deaminase in Saccharomyces cerevisiae. Eur J Biochem. 1982;123:571-6 pubmed
    ..These two enzymes, which thus can be easily differentiated by means of their regulations, display a limited ability to compensate for one another's absence and appear to play clearly distinct roles under normal physiological conditions. ..
  4. Chen X, Wang X, Kaufman B, Butow R. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science. 2005;307:714-7 pubmed
    ..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance. ..
  5. He Q, Battistella L, Morse R. Mediator requirement downstream of chromatin remodeling during transcriptional activation of CHA1 in yeast. J Biol Chem. 2008;283:5276-86 pubmed
    ..Here we have used the yeast CHA1 gene to study the role of Mediator in chromatin remodeling and recruitment of the transcription machinery...
  6. He Q, Yu C, Morse R. Dispersed mutations in histone H3 that affect transcriptional repression and chromatin structure of the CHA1 promoter in Saccharomyces cerevisiae. Eukaryot Cell. 2008;7:1649-60 pubmed publisher prevent the constitutively bound activator Cha4 from remodeling chromatin and activating transcription at the CHA1 gene in Saccharomyces cerevisiae...
  7. Leung A, Cajigas I, Jia P, Ezhkova E, Brickner J, Zhao Z, et al. Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat. Mol Biol Cell. 2011;22:2741-53 pubmed publisher
    ..Our data reveal that H2B ubiquitylation/H3K4 methylation play an important role in limiting ectopic association of silencing proteins with euchromatic genes important for cell wall integrity and the response to heat. ..