CDC11

Summary

Gene Symbol: CDC11
Description: septin CDC11
Alias: PSL9, septin CDC11
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Sinha I, Wang Y, Philp R, Li C, Yap W, Wang Y. Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development. Dev Cell. 2007;13:421-32 pubmed
    ..Ccn1 and Hgc1, rapidly establishes and persistently maintains phosphorylation of the septin cytoskeleton protein Cdc11 for hyphal development...
  2. Hartwell L. Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res. 1971;69:265-76 pubmed
  3. Iwase M, Luo J, Bi E, Toh e A. Shs1 plays separable roles in septin organization and cytokinesis in Saccharomyces cerevisiae. Genetics. 2007;177:215-29 pubmed
    In Saccharomyces cerevisiae, five septins (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1/Sep7) form the septin ring at the bud neck during vegetative growth...
  4. Bouquin N, Barral Y, Courbeyrette R, Blondel M, Snyder M, Mann C. Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae. J Cell Sci. 2000;113 ( Pt 8):1435-45 pubmed
    ..Elm1 is a protein kinase, thought to be a negative regulator of pseudo-hyphal growth. We show that Cdc11, one of the septins, is delocalised in the mutant, indicating that septin localisation is partly controlled by ..
  5. Carroll C, Altman R, Schieltz D, Yates J, Kellogg D. The septins are required for the mitosis-specific activation of the Gin4 kinase. J Cell Biol. 1998;143:709-17 pubmed
    ..These results demonstrate that the septins in budding yeast play an integral role in the mitosis-specific regulation of the Gin4 kinase and that they carry out functions early in mitosis. ..
  6. Garcia G, Bertin A, Li Z, Song Y, McMurray M, Thorner J, et al. Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation. J Cell Biol. 2011;195:993-1004 pubmed publisher
    ..In budding yeast, five mitotic septins (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1), which are essential for cytokinesis, transition during bud growth from a patch to a collar, ..
  7. Bertin A, McMurray M, Grob P, Park S, Garcia G, Patanwala I, et al. Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A. 2008;105:8274-9 pubmed publisher
    Mitotic yeast cells express five septins (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1/Sep7). Only Shs1 is nonessential. The four essential septins form a complex containing two copies of each, but their arrangement was not known...
  8. Iwase M, Luo J, Nagaraj S, Longtine M, Kim H, Haarer B, et al. Role of a Cdc42p effector pathway in recruitment of the yeast septins to the presumptive bud site. Mol Biol Cell. 2006;17:1110-25 pubmed
    ..Two-hybrid, in vitro protein binding, and coimmunoprecipitation data indicate that this role involves a direct interaction of the Gic proteins with the septin Cdc12p. ..
  9. Farkasovsky M, Herter P, Voss B, Wittinghofer A. Nucleotide binding and filament assembly of recombinant yeast septin complexes. Biol Chem. 2005;386:643-56 pubmed
    ..In the yeast Saccharomyces cerevisiae, the septins encoded by CDC3, CDC10, CDC11, and CDC12 form a high-molecular-weight complex, localized at the cytoplasmic face of the plasma membrane in the ..

More Information

Publications53

  1. Versele M, Gullbrand B, Shulewitz M, Cid V, Bahmanyar S, Chen R, et al. Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell. 2004;15:4568-83 pubmed
    Mitotic yeast (Saccharomyces cerevisiae) cells express five related septins (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1) that form a cortical filamentous collar at the mother-bud neck necessary for normal morphogenesis and cytokinesis...
  2. Casamayor A, Snyder M. Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization, and function. Mol Cell Biol. 2003;23:2762-77 pubmed
    ..We have studied the role of each domain in the Saccharomyces cerevisiae septin Cdc11 and found that the three domains are responsible for distinct and sometimes overlapping functions...
  3. Iwase M, Toh e A. Nis1 encoded by YNL078W: a new neck protein of Saccharomyces cerevisiae. Genes Genet Syst. 2001;76:335-43 pubmed
    ..GFP-Nis1 is localized in the nucleus throughout the cell cycle and in the bud neck at G2/M phase in a septin-dependent manner. Altogether, the findings suggest that Nis1 may play a non-essential role in the mitotic signaling network. ..
  4. Lee P, Song S, Ro H, Park C, Lippincott J, Li R, et al. Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae. Mol Cell Biol. 2002;22:6906-20 pubmed
    ..Overexpression of BNI5 also suppressed the growth defects of cdc10-1, cdc11-6, and sep7Delta strains...
  5. Frazier J, Wong M, Longtine M, Pringle J, Mann M, Mitchison T, et al. Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function. J Cell Biol. 1998;143:737-49 pubmed
    ..between these filaments and the neck filaments, we purified septin complexes from cells deleted for CDC10 or CDC11. These complexes were not capable of the polymerization exhibited by wild-type preparations, and analysis of the ..
  6. Egelhofer T, Villen J, McCusker D, Gygi S, Kellogg D. The septins function in G1 pathways that influence the pattern of cell growth in budding yeast. PLoS ONE. 2008;3:e2022 pubmed publisher
    ..Phosphorylation of Shs1 by G1 cyclin-dependent kinases plays a role in events that influence Cdk1 inhibitory phosphorylation...
  7. Ford S, Pringle J. Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: localization of the CDC11 gene product and the timing of events at the budding site. Dev Genet. 1991;12:281-92 pubmed
    The Saccharomyces cerevisiae CDC3, CDC10, CDC11, and CDC12 genes encode a family of homologous proteins that are not closely related to other known proteins [Haarer BK, Ketcham SR, Ford SK, Ashcroft DJ, and Pringle JR (submitted)]...
  8. Nam S, Sung H, Kang S, Joo J, Lee S, Chung Y, et al. Phosphorylation-dependent septin interaction of Bni5 is important for cytokinesis. J Microbiol. 2007;45:227-33 pubmed
    ..Here, we provide evidence that Bni5 phosphorylation is important for interaction with septin component Cdc11 and for timely delocalization from septin filament at late mitosis...
  9. Mortensen E, McDonald H, Yates J, Kellogg D. Cell cycle-dependent assembly of a Gin4-septin complex. Mol Biol Cell. 2002;13:2091-105 pubmed
    ..complex, and we found that the majority of the Shs1 in the cell is tightly bound to the other septins Cdc3, Cdc10, Cdc11, and Cdc12...
  10. Johnson E, Blobel G. Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins. J Cell Biol. 1999;147:981-94 pubmed
    ..We have found that SUMO is attached to the septins Cdc3, Cdc11, and Shs1/Sep7 specifically during mitosis, with conjugates appearing shortly before anaphase onset and ..
  11. Longtine M, Demarini D, Valencik M, Al Awar O, Fares H, De Virgilio C, et al. The septins: roles in cytokinesis and other processes. Curr Opin Cell Biol. 1996;8:106-19 pubmed
    ..The septins also appear to be involved in various other aspects of the organization of the cell surface. ..
  12. Takahashi Y, Toh e A, Kikuchi Y. A novel factor required for the SUMO1/Smt3 conjugation of yeast septins. Gene. 2001;275:223-31 pubmed
    ..A conserved cysteine residue in the domain was essential for this conjugation. Furthermore, Siz1 was localized at the mother-bud neck in the M-phase and physically bound to both E2 and the target proteins. ..
  13. McMurray M, Bertin A, Garcia G, Lam L, Nogales E, Thorner J. Septin filament formation is essential in budding yeast. Dev Cell. 2011;20:540-9 pubmed publisher
    ..In Saccharomyces cerevisiae, four septins form an apolar hetero-octamer (Cdc11-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3-Cdc12-Cdc11) that associates end-to-end to form filaments...
  14. Barral Y, Mermall V, Mooseker M, Snyder M. Compartmentalization of the cell cortex by septins is required for maintenance of cell polarity in yeast. Mol Cell. 2000;5:841-51 pubmed
    ..We propose that septins maintain cell polarity by specifying a boundary between cortical domains. ..
  15. Schmidt M, Varma A, Drgon T, Bowers B, Cabib E. Septins, under Cla4p regulation, and the chitin ring are required for neck integrity in budding yeast. Mol Biol Cell. 2003;14:2128-41 pubmed
    CLA4, encoding a protein kinase of the PAK type, and CDC11, encoding a septin, were isolated in a screen for synthetic lethality with CHS3, which encodes the chitin synthase III catalytic moiety...
  16. Fares H, Goetsch L, Pringle J. Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiae. J Cell Biol. 1996;132:399-411 pubmed
    The Saccharomyces cerevisiae CDC3, CDC10, CDC11, and CDC12 genes encode a family of related proteins, the septins, which are involved in cell division and the organization of the cell surface during vegetative growth...
  17. Longtine M, Theesfeld C, McMillan J, Weaver E, Pringle J, Lew D. Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol. 2000;20:4049-61 pubmed
    ..e., after a bud has formed). ..
  18. Booth E, Sterling S, Dovala D, Nogales E, Thorner J. Effects of Bni5 Binding on Septin Filament Organization. J Mol Biol. 2016;428:4962-4980 pubmed publisher
    ..We found that the interaction of Bni5 with the terminal subunit (Cdc11) at the junctions between adjacent hetero-octamers in paired filaments is highly cooperative...
  19. Versele M, Thorner J. Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol. 2004;164:701-15 pubmed
    Assembly at the mother-bud neck of a filamentous collar containing five septins (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1) is necessary for proper morphogenesis and cytokinesis...
  20. Shirai C, Mizuta K. SUMO mediates interaction of Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, with a RING finger protein Ris1p. Biosci Biotechnol Biochem. 2008;72:1881-6 pubmed
    ..A SUMO-binding motif of Ris1p was required for interaction with Ebp2p. These results suggest that SUMO mediates the interaction between Ebp2p and SUMO related proteins and that Ebp2p switches its interaction partners via sumoylation. ..
  21. Weems A, MCMURRAY M. The step-wise pathway of septin hetero-octamer assembly in budding yeast. elife. 2017;6: pubmed publisher
    ..assay, we find that a stepwise assembly pathway produces the two species of budding yeast septin hetero-octamers: Cdc11/Shs1-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3-Cdc12-Cdc11/Shs1...
  22. Sung H, Chul Han K, Chul Kim J, Wan Oh K, Su Yoo H, Tae Hong J, et al. A set of epitope-tagging integration vectors for functional analysis in Saccharomyces cerevisiae. FEMS Yeast Res. 2005;5:943-50 pubmed
    ..To confirm function and expression of C-terminal-tagged proteins, we used Cdc11, a component of the septin filament that encircles the mother bud neck and consists of five major proteins: Cdc3, ..
  23. Johnson C, Weems A, Brewer J, Thorner J, McMurray M. Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast. Mol Biol Cell. 2015;26:1323-44 pubmed publisher
    ..These findings provide new roles for chaperone-mediated kinetic partitioning of non-native proteins and may help explain the etiology of septin-linked human diseases. ..
  24. Pablo Hernando M, Arnaiz Pita Y, Tachikawa H, del Rey F, Neiman A, Vazquez de Aldana C. Septins localize to microtubules during nutritional limitation in Saccharomyces cerevisiae. BMC Cell Biol. 2008;9:55 pubmed publisher
    ..that nutrient limitation triggers a change in the localization of at least two vegetative septins (Cdc10 and Cdc11) from the bud neck to the microtubules...
  25. Booth E, Vane E, Dovala D, Thorner J. A Förster Resonance Energy Transfer (FRET)-based System Provides Insight into the Ordered Assembly of Yeast Septin Hetero-octamers. J Biol Chem. 2015;290:28388-401 pubmed publisher
    ..In mitotically growing yeast cells, five septin subunits are expressed (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1) and assemble into two types of rods that differ only in their terminal subunit: Cdc11-Cdc12-Cdc3-..
  26. Oh Y, Schreiter J, Nishihama R, Wloka C, Bi E. Targeting and functional mechanisms of the cytokinesis-related F-BAR protein Hof1 during the cell cycle. Mol Biol Cell. 2013;24:1305-20 pubmed publisher
  27. Finnigan G, Booth E, Duvalyan A, Liao E, Thorner J. The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae. Genetics. 2015;200:843-62 pubmed publisher
    ..demonstrated that the C-terminal extensions (CTEs) of the alternative terminal subunits of septin heterooctamers, Cdc11 and Shs1, share a role required for optimal septin function in vivo...
  28. Brausemann A, Gerhardt S, Schott A, Einsle O, Große Berkenbusch A, Johnsson N, et al. Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae. J Struct Biol. 2016;193:157-161 pubmed publisher
    ..We present here the first crystal structure of Cdc11, the terminal subunit of the octameric rod and discuss its structure in relation to its human homologues...
  29. Finnigan G, Takagi J, Cho C, Thorner J. Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae. Genetics. 2015;200:821-41 pubmed publisher
    ..The two most related and recently evolved subunits appear to be Cdc11 and Shs1, and the basic building blocks for assembling septin structures are hetero-octameric rods (Cdc11-Cdc12-..
  30. Finnigan G, Sterling S, Duvalyan A, Liao E, Sargsyan A, Garcia G, et al. Coordinate action of distinct sequence elements localizes checkpoint kinase Hsl1 to the septin collar at the bud neck in Saccharomyces cerevisiae. Mol Biol Cell. 2016;27:2213-33 pubmed publisher
  31. Chahwan R, Gravel S, Matsusaka T, Jackson S. Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins. Cell Cycle. 2013;12:1000-8 pubmed publisher
    ..We show that Dma2 has ubiquitin ligase activity, and that septins Shs1 and Cdc11 are likely direct in vivo targets...
  32. Elmore Z, Donaher M, Matson B, Murphy H, Westerbeck J, Kerscher O. Sumo-dependent substrate targeting of the SUMO protease Ulp1. BMC Biol. 2011;9:74 pubmed publisher
    ..Furthermore, we found that a substrate-trapping Ulp1(3)(C580S) interacts robustly with human SUMO1, SUMO2 and SUMO2 chains, making it a potentially useful tool for the analysis and purification of SUMO-modified proteins. ..
  33. Okuzaki D, Nojima H. Kcc4 associates with septin proteins of Saccharomyces cerevisiae. FEBS Lett. 2001;489:197-201 pubmed
    ..From the results obtained here, we suggest that Cdc11 is the primary association partner of Kcc4.
  34. Renz C, Johnsson N, Gronemeyer T. An efficient protocol for the purification and labeling of entire yeast septin rods from E.coli for quantitative in vitro experimentation. BMC Biotechnol. 2013;13:60 pubmed publisher
    ..In yeast, they comprise a family of proteins (Cdc3, Cdc10, Cdc11, Cdc12, Shs1) that form a co-polymeric, ring-like structure beneath the membrane...
  35. Okada S, Leda M, Hanna J, Savage N, Bi E, Goryachev A. Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis. Dev Cell. 2013;26:148-61 pubmed publisher
    ..Our findings define a fundamental mechanism underlying eukaryotic cell fate differentiation. ..
  36. Hanrahan J, Snyder M. Cytoskeletal activation of a checkpoint kinase. Mol Cell. 2003;12:663-73 pubmed
    ..lie near and overlap the inhibitory domain; these are important for Hsl1 function, and binding of two septins, Cdc11 and Cdc12, relieves the autoinhibition imposed by the kinase inhibitory domain in vitro...
  37. García Rodriguez L, Duran A, Roncero C. Calcofluor antifungal action depends on chitin and a functional high-osmolarity glycerol response (HOG) pathway: evidence for a physiological role of the Saccharomyces cerevisiae HOG pathway under noninducing conditions. J Bacteriol. 2000;182:2428-37 pubmed
  38. Song S, Lee K. A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis. J Cell Biol. 2001;152:451-69 pubmed
    ..The polo-box-dependent interactions between Cdc5 and septins (Cdc11 and Cdc12) and genetic interactions between the dominant-negative cdc5DeltaN and Cyk2/Hof1 or Myo1 suggest that ..
  39. de Val N, McMurray M, Lam L, Hsiung C, Bertin A, Nogales E, et al. Native cysteine residues are dispensable for the structure and function of all five yeast mitotic septins. Proteins. 2013;81:1964-79 pubmed publisher
    ..mutagenesis was used, first, to replace the native Cys residues in Cdc3 (C124 C253 C279), Cdc10 (C266), Cdc11 (C43 C137 C138), Cdc12 (C40 C278), and Shs1 (C29 C148) with Ala, Ser, Val, or Phe...
  40. Madden K, Snyder M. Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol. 1998;52:687-744 pubmed
    ..Since many of the components important for polarized cell growth are conserved in other organisms, the basic mechanisms mediating polarized cell growth are likely to be universal among eukaryotes. ..
  41. Qiu W, Neo S, Yu X, Cai M. A novel septin-associated protein, Syp1p, is required for normal cell cycle-dependent septin cytoskeleton dynamics in yeast. Genetics. 2008;180:1445-57 pubmed publisher
    ..These results suggest that Syp1p is involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton in yeast. ..
  42. Nagaraj S, Rajendran A, Jackson C, Longtine M. Role of nucleotide binding in septin-septin interactions and septin localization in Saccharomyces cerevisiae. Mol Cell Biol. 2008;28:5120-37 pubmed publisher
    ..We find no evidence that nucleotide binding is specifically involved in the interaction of septins with septin-associated proteins. ..
  43. Garcia G, Finnigan G, Heasley L, Sterling S, Aggarwal A, Pearson C, et al. Assembly, molecular organization, and membrane-binding properties of development-specific septins. J Cell Biol. 2016;212:515-29 pubmed publisher
    ..is addressed in budding yeast, where during meiosis Spr3 and Spr28 replace the mitotic septin subunits Cdc12 and Cdc11 (and Shs1), respectively...
  44. Yuan S, Nie W, He F, Jia Z, Gao X. Kin2, the Budding Yeast Ortholog of Animal MARK/PAR-1 Kinases, Localizes to the Sites of Polarized Growth and May Regulate Septin Organization and the Cell Wall. PLoS ONE. 2016;11:e0153992 pubmed publisher
    ..Both TD1 and TD2 contribute to this function. Moreover, we find that the C-terminal region of Kin2 interacts with Cdc11, a septin subunit, and Pea2, a component of the polarisome that is known to play a role in septin organization...