Gene Symbol: CCE1
Description: cruciform cutting endonuclease
Alias: MGT1, cruciform cutting endonuclease
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Mookerjee S, Sia E. Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae. Mutat Res. 2006;595:91-106 pubmed
    ..We present new evidence that the putative recombination genes CCE1, DIN7, and MHR1 have overlapping function with the mismatch repair homolog MSH1 in point mutation avoidance and ..
  2. Armakola M, Higgins M, Figley M, Barmada S, Scarborough E, Diaz Z, et al. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012;44:1302-9 pubmed publisher
    ..Our findings provide insight into TDP-43-mediated cytotoxicity and suggest that decreasing Dbr1 activity could be a potential therapeutic approach for ALS. ..
  3. Samoilova E, Krasheninnikov I, Levitskii S. Interaction between Saccharomyces cerevisiae Mitochondrial DNA-Binding Protein Abf2p and Cce1p Resolvase. Biochemistry (Mosc). 2016;81:1111-1117 pubmed
    ..These data suggest the existence of an alternative homologous recombination pathway in yeast mitochondria. ..
  4. Sembongi H, Di Re M, Bokori Brown M, Holt I. The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA. Hum Mol Genet. 2007;16:2306-14 pubmed
    ..Therefore, the yeast CCE1 gene, encoding a Holliday junction resolvase, was introduced into cells carrying partially duplicated or partially ..
  5. Ezekiel U, Zassenhaus H. Localization of a cruciform cutting endonuclease to yeast mitochondria. Mol Gen Genet. 1993;240:414-8 pubmed
    We have found a cruciform cutting endonuclease in the yeast, Saccharomyces cerevisiae, which localizes to the mitochondria...
  6. Ling F, Shibata T. Recombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA. EMBO J. 2002;21:4730-40 pubmed
    ..These results suggest a mechanism for mtDNA inheritance similar to that operating in the replication and packaging of phage DNA. ..