CAT2

Summary

Gene Symbol: CAT2
Description: carnitine O-acetyltransferase CAT2
Alias: YCAT, carnitine O-acetyltransferase CAT2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Kispal G, Sumegi B, Dietmeier K, Bock I, Gajdos G, Tomcsanyi T, et al. Cloning and sequencing of a cDNA encoding Saccharomyces cerevisiae carnitine acetyltransferase. Use of the cDNA in gene disruption studies. J Biol Chem. 1993;268:1824-9 pubmed
    ..These results suggest diminished flux through the pyruvate dehydrogenase complex in the absence of mitochondrial CAT in yeast cells. ..
  2. Swiegers J, Dippenaar N, Pretorius I, Bauer F. Carnitine-dependent metabolic activities in Saccharomyces cerevisiae: three carnitine acetyltransferases are essential in a carnitine-dependent strain. Yeast. 2001;18:585-95 pubmed
    ..Complementation of three of these mutants resulted in the cloning of three CAT encoding genes: CAT2, coding for the carnitine acetyltransferase associated with the peroxisomes and the mitochondria; YAT1, coding for ..
  3. Zimmermann F, Kaufmann I, Rasenberger H, Haubetamann P. Genetics of carbon catabolite repression in Saccharomycess cerevisiae: genes involved in the derepression process. Mol Gen Genet. 1977;151:95-103 pubmed
    ..One was recessive, acted as a suppressor of cat1-1 and was called cat2-1, wild type CAT2; the other was dominant and allelic to CAT1 and designated CAT1-2d and cat2-1 caused an earlier ..
  4. Violante S, IJlst L, van Lenthe H, de Almeida I, Wanders R, Ventura F. Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling. Biochim Biophys Acta. 2010;1802:728-32 pubmed publisher
  5. Oeljeklaus S, Reinartz B, Wolf J, Wiese S, Tonillo J, Podwojski K, et al. Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis. J Proteome Res. 2012;11:2567-80 pubmed publisher
  6. Elgersma Y, van Roermund C, Wanders R, Tabak H. Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene. EMBO J. 1995;14:3472-9 pubmed
    ..Both proteins are encoded by the same gene, YCAT, which encodes a protein with a mitochondrial targeting signal (MTS) at the N-terminus, and a peroxisomal targeting ..
  7. Hiltunen J, Mursula A, Rottensteiner H, Wierenga R, Kastaniotis A, Gurvitz A. The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev. 2003;27:35-64 pubmed
  8. Franken J, Kroppenstedt S, Swiegers J, Bauer F. Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection. Curr Genet. 2008;53:347-60 pubmed publisher
    ..double and triple deletions of the three CAT genes generally present identical phenotypes, but that the deletion of CAT2 decreases survival during oxidative stress in a carnitine-independent manner...