Gene Symbol: CAT2
Description: carnitine O-acetyltransferase CAT2
Alias: YCAT, carnitine O-acetyltransferase CAT2
Species: Saccharomyces cerevisiae S288c
Kispal G, Sumegi B, Dietmeier K, Bock I, Gajdos G, Tomcsanyi T, et al
. Cloning and sequencing of a cDNA encoding Saccharomyces cerevisiae carnitine acetyltransferase. Use of the cDNA in gene disruption studies. J Biol Chem. 1993;268:1824-9 pubmed
..These results suggest diminished flux through the pyruvate dehydrogenase complex in the absence of mitochondrial CAT in yeast cells. ..
Swiegers J, Dippenaar N, Pretorius I, Bauer F. Carnitine-dependent metabolic activities in Saccharomyces cerevisiae: three carnitine acetyltransferases are essential in a carnitine-dependent strain. Yeast. 2001;18:585-95 pubmed
..Complementation of three of these mutants resulted in the cloning of three CAT encoding genes: CAT2, coding for the carnitine acetyltransferase associated with the peroxisomes and the mitochondria; YAT1, coding for ..
Zimmermann F, Kaufmann I, Rasenberger H, Haubetamann P. Genetics of carbon catabolite repression in Saccharomycess cerevisiae: genes involved in the derepression process. Mol Gen Genet. 1977;151:95-103 pubmed
..One was recessive, acted as a suppressor of cat1-1 and was called cat2-1, wild type CAT2; the other was dominant and allelic to CAT1 and designated CAT1-2d and cat2-1 caused an earlier ..
Violante S, IJlst L, van Lenthe H, de Almeida I, Wanders R, Ventura F. Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling. Biochim Biophys Acta. 2010;1802:728-32 pubmed publisher
Oeljeklaus S, Reinartz B, Wolf J, Wiese S, Tonillo J, Podwojski K, et al
. Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis. J Proteome Res. 2012;11:2567-80 pubmed publisher
Elgersma Y, van Roermund C, Wanders R, Tabak H. Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene. EMBO J. 1995;14:3472-9 pubmed
..Both proteins are encoded by the same gene, YCAT, which encodes a protein with a mitochondrial targeting signal (MTS) at the N-terminus, and a peroxisomal targeting ..
Hiltunen J, Mursula A, Rottensteiner H, Wierenga R, Kastaniotis A, Gurvitz A. The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev. 2003;27:35-64 pubmed
Franken J, Kroppenstedt S, Swiegers J, Bauer F. Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection. Curr Genet. 2008;53:347-60 pubmed publisher
..double and triple deletions of the three CAT genes generally present identical phenotypes, but that the deletion of CAT2 decreases survival during oxidative stress in a carnitine-independent manner...