Gene Symbol: CAB3
Description: phosphopantothenoylcysteine decarboxylase complex subunit CAB3
Alias: phosphopantothenoylcysteine decarboxylase complex subunit CAB3
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Di Como C, Bose R, Arndt K. Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants. Genetics. 1995;139:95-107 pubmed
  2. Olzhausen J, Schübbe S, Schüller H. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet. 2009;55:163-73 pubmed publisher
    ..Comparative expression analyses showed that some CoA biosynthetic genes are weakly de-repressed with ethanol as a carbon source compared with glucose. ..
  3. Olzhausen J, Moritz T, Neetz T, Schüller H. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2013;13:565-73 pubmed publisher
    ..In addition, nonessential genes SIS2 and VHS3 similar to CAB3 are also involved...
  4. Rodriguez P, Ali R, Serrano R. CtCdc55p and CtHa13p: two putative regulatory proteins from Candida tropicalis with long acidic domains. Yeast. 1996;12:1321-9 pubmed
    ..cerevisiae cdc55 mutant. The presence of acidic domains in different putative regulatory proteins may suggest a role for this type of domain in molecular interactions. ..
  5. Tatusov R, Galperin M, Natale D, Koonin E. The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res. 2000;28:33-6 pubmed
    ..The COG database is accompanied by the COGNITOR program that is used to fit new proteins into the COGs and can be applied to functional and phylogenetic annotation of newly sequenced genomes. ..
  6. Ruiz A, González A, Munoz I, Serrano R, Abrie J, Strauss E, et al. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol. 2009;5:920-8 pubmed publisher
    ..Our results unveil Hal3 and Vhs3 as moonlighting proteins involved in both CoA biosynthesis and protein phosphatase regulation. ..
  7. Abrie J, Molero C, Ariño J, Strauss E. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Sci Rep. 2015;5:15774 pubmed publisher
    ..proteins, acting both as inhibitors of the serine/threonine protein phosphatase Ppz1 and as subunits (together with Cab3) of the unique heterotrimeric phosphopantothenoylcysteine decarboxylase (PPCDC) enzyme of Hemiascomycetous yeast...