CAB2

Summary

Gene Symbol: CAB2
Description: phosphopantothenate--cysteine ligase CAB2
Alias: phosphopantothenate--cysteine ligase CAB2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, De Crecy Lagard V, et al. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J Biol Chem. 2002;277:21431-9 pubmed
    ..This enzyme was previously suggested as a point of CoA biosynthesis regulation, and we have observed significant differences in mRNA levels of the corresponding human gene in normal and tumor cells by Northern blot analysis. ..
  2. Olzhausen J, Schübbe S, Schüller H. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet. 2009;55:163-73 pubmed publisher
    ..Comparative expression analyses showed that some CoA biosynthetic genes are weakly de-repressed with ethanol as a carbon source compared with glucose. ..
  3. Olzhausen J, Moritz T, Neetz T, Schüller H. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2013;13:565-73 pubmed publisher
    ..We thus systematically investigated interactions among Cab proteins. Our results show that Cab2, Cab3, Cab4, and Cab5 indeed bind to each other, with Cab3 as the sole protein, which can interact with itself and ..