Gene Symbol: BUD3
Description: Bud3p
Alias: YCL012W, Bud3p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Kang P, Angerman E, Jung C, Park H. Bud4 mediates the cell-type-specific assembly of the axial landmark in budding yeast. J Cell Sci. 2012;125:3840-9 pubmed publisher
    ..Haploid a and ? cells bud in the axial budding pattern, which depends on a transient marker and requires proteins Bud3, Bud4, Axl1 and Axl2...
  2. Chant J, Mischke M, Mitchell E, Herskowitz I, Pringle J. Role of Bud3p in producing the axial budding pattern of yeast. J Cell Biol. 1995;129:767-78 pubmed
    ..The sequence of BUD3 predicts a product (Bud3p) of 1635 amino acids with no strong or instructive similarities to previously known proteins...
  3. Kang P, Hood Degrenier J, Park H. Coupling of septins to the axial landmark by Bud4 in budding yeast. J Cell Sci. 2013;126:1218-26 pubmed publisher
    ..Instead, this C-terminal region is crucial for association of Bud4 with Bud3 and other components of the axial landmark...
  4. Gao X, Sperber L, Kane S, Tong Z, Tong A, Boone C, et al. Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle. Mol Biol Cell. 2007;18:2542-60 pubmed
    ..it is not known when and how Axl2p functions together with other components of the axial landmark, such as Bud3p and Bud4p, to direct axial budding...
  5. Roemer T, Madden K, Chang J, Snyder M. Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein. Genes Dev. 1996;10:777-93 pubmed
    ..Genetic analysis indicates that AXL2 falls into the same epistasis group as BUD3. Axl2p is predicted to be a type I transmembrane protein...
  6. Chant J, Herskowitz I. Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway. Cell. 1991;65:1203-12 pubmed
    ..as the previously identified gene RSR1) or BUD2 lead to a random budding pattern in all cell types; mutations in BUD3 or BUD4 lead to a bipolar pattern in all cell types...
  7. Wu H, Guo J, Zhou Y, Gao X. The anillin-related region of Bud4 is the major functional determinant for Bud4's function in septin organization during bud growth and axial bud site selection in budding yeast. Eukaryot Cell. 2015;14:241-51 pubmed publisher
    ..We show that this region interacts with the C terminus of Bud3 and the two segments depend on each other for association with the septins...
  8. Panni S, Montecchi Palazzi L, Kiemer L, Cabibbo A, Paoluzi S, Santonico E, et al. Combining peptide recognition specificity and context information for the prediction of the 14-3-3-mediated interactome in S. cerevisiae and H. sapiens. Proteomics. 2011;11:128-43 pubmed publisher
    ..Our approach provides an orthogonal reliability assessment and maps with high confidence the 14-3-3 peptide target on the partner proteins. ..
  9. Dagkessamanskaia A, Durand F, Uversky V, Binda M, Lopez F, El Azzouzi K, et al. Functional dissection of an intrinsically disordered protein: understanding the roles of different domains of Knr4 protein in protein-protein interactions. Protein Sci. 2010;19:1376-85 pubmed publisher

More Information


  1. Eluère R, Varlet I, Bernadac A, Simon M. Cdk and the anillin homolog Bud4 define a new pathway regulating septin organization in yeast. Cell Cycle. 2012;11:151-8 pubmed publisher
    ..Bud4 acts with Bud3 in this pathway and in parallel with septin phosphorylation by the p21-activated kinase Cla4 and the septin-..
  2. Cullen P, Sprague G. The roles of bud-site-selection proteins during haploid invasive growth in yeast. Mol Biol Cell. 2002;13:2990-3004 pubmed
    ..Three of the four known proteins required for axial budding, Bud3p, Bud4p, and Axl2p, were expressed and localized appropriately in glucose-limiting conditions...
  3. Elia L, Marsh L. A role for a protease in morphogenic responses during yeast cell fusion. J Cell Biol. 1998;142:1473-85 pubmed
    ..Two other bud site selection genes, RSR1, encoding a small GTPase, and BUD3, were also required for efficient cell fusion...
  4. Chiroli E, Rancati G, Catusi I, Lucchini G, Piatti S. Cdc14 inhibition by the spindle assembly checkpoint prevents unscheduled centrosome separation in budding yeast. Mol Biol Cell. 2009;20:2626-37 pubmed publisher
    ..We propose that, besides inhibiting sister chromatid separation, the SAC preserves the accurate transmission of chromosomes also by preventing SPBs to migrate far apart until the conditions to assemble a bipolar spindle are satisfied. ..
  5. Bailly E, Cabantous S, Sondaz D, Bernadac A, Simon M. Differential cellular localization among mitotic cyclins from Saccharomyces cerevisiae: a new role for the axial budding protein Bud3 in targeting Clb2 to the mother-bud neck. J Cell Sci. 2003;116:4119-30 pubmed
    ..Clb2 co-localizes with the bud site selection protein Bud3. Consistent with a role of Bud3 in targeting Clb2 to the bud neck, we report a two-hybrid interaction between these ..
  6. Kang P, Lee M, Park H. Bud3 activates Cdc42 to establish a proper growth site in budding yeast. J Cell Biol. 2014;206:19-28 pubmed publisher
    ..and live-cell imaging, we show that cell polarization to a proper growth site requires activation of Cdc42 by Bud3 in haploid budding yeast...
  7. Thompson D, Stahl F. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Genetics. 1999;153:621-41 pubmed
    ..lethal phenotype in diploid SPO13 meiosis in our strain background, and they identify alleles of UBR1, INP52, BUD3, PET122, ELA1, and MSC1-MSC3...
  8. Kao L, Wang Y, Chen Y, Tseng S, Jhang J, Chen Y, et al. Global analysis of cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis. Mol Cell Proteomics. 2014;13:594-605 pubmed publisher
    ..two events, and through functional studies we discovered that Cdc14-mediated dephosphorylation of Smc4 and Bud3 is essential for proper mitosis and cytokinesis, respectively...
  9. Madden K, Snyder M. Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol. 1998;52:687-744 pubmed
    ..Since many of the components important for polarized cell growth are conserved in other organisms, the basic mechanisms mediating polarized cell growth are likely to be universal among eukaryotes. ..