BRN1

Summary

Gene Symbol: BRN1
Description: condensin subunit BRN1
Alias: condensin subunit BRN1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Strunnikov A, Hogan E, Koshland D. SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family. Genes Dev. 1995;9:587-99 pubmed
  2. D Ambrosio C, Kelly G, Shirahige K, Uhlmann F. Condensin-dependent rDNA decatenation introduces a temporal pattern to chromosome segregation. Curr Biol. 2008;18:1084-9 pubmed publisher
    ..Regulation of decatenation therefore provides a means to fine tune the segregation timing of chromosomes in mitosis. ..
  3. Freeman L, Aragon Alcaide L, Strunnikov A. The condensin complex governs chromosome condensation and mitotic transmission of rDNA. J Cell Biol. 2000;149:811-24 pubmed
    ..Thus, the rDNA array is the first identified set of DNA sequences specifically bound by condensin in vivo. The biological role of higher-order chromosome structure in S. cerevisiae is discussed. ..
  4. St Pierre J, Douziech M, Bazile F, Pascariu M, Bonneil E, Sauvé V, et al. Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity. Mol Cell. 2009;34:416-26 pubmed publisher
    ..Our results reveal the existence of a regulatory mechanism essential for the promotion of genome integrity through the stimulation of chromosome condensation in late mitosis. ..
  5. Mahendrawada L, Rai R, Kothiwal D, Laloraya S. Interplay between Top1 and Mms21/Nse2 mediated sumoylation in stable maintenance of long chromosomes. Curr Genet. 2017;63:627-645 pubmed publisher
  6. Doughty T, Arsenault H, Benanti J. Levels of Ycg1 Limit Condensin Function during the Cell Cycle. PLoS Genet. 2016;12:e1006216 pubmed publisher
  7. Haeusler R, Pratt Hyatt M, Good P, Gipson T, Engelke D. Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev. 2008;22:2204-14 pubmed publisher
    ..These observations suggest a widespread role for condensin in gene organization and packaging of the interphase yeast nucleus. ..
  8. Bertazzi D, Kurtulmus B, Pereira G. The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4. J Cell Biol. 2011;193:1033-48 pubmed publisher
    ..This Lte1-mediated exclusion of Kin4 from the dSPB is essential for proper mitotic exit of cells with a correctly aligned spindle. Therefore, Lte1 promotes mitotic exit by inhibiting Kin4 activity at the dSPB. ..
  9. D Ambrosio C, Schmidt C, Katou Y, Kelly G, Itoh T, Shirahige K, et al. Identification of cis-acting sites for condensin loading onto budding yeast chromosomes. Genes Dev. 2008;22:2215-27 pubmed publisher
    ..This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis...

More Information

Publications19

  1. Li Z, Vizeacoumar F, Bahr S, Li J, Warringer J, Vizeacoumar F, et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol. 2011;29:361-7 pubmed publisher
    ..This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes. ..
  2. Jaquenoud M, Peter M. Gic2p may link activated Cdc42p to components involved in actin polarization, including Bni1p and Bud6p (Aip3p). Mol Cell Biol. 2000;20:6244-58 pubmed
    ..We propose that at bud emergence, Gic2p functions as an adaptor which may link activated Cdc42p to components involved in actin organization and polarized growth, including Bni1p, Spa2p, and Bud6p. ..
  3. Ouspenski I, Cabello O, Brinkley B. Chromosome condensation factor Brn1p is required for chromatid separation in mitosis. Mol Biol Cell. 2000;11:1305-13 pubmed
    This work describes BRN1, the budding yeast homologue of Drosophila Barren and Xenopus condensin subunit XCAP-H...
  4. Yong Gonzalez V, Wang B, Butylin P, Ouspenski I, Strunnikov A. Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids. Genes Cells. 2007;12:1075-90 pubmed
    ..These findings show that, in addition to its essential role in rDNA segregation, condensin mediates segregation of the whole genome by maintaining the centromere structure in Saccharomyces cerevisiae. ..
  5. Varela E, Shimada K, Laroche T, Leroy D, Gasser S. Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression. EMBO J. 2009;28:1562-75 pubmed publisher
    ..We have localized the Condensin subunit Brn1 to a compact spiral of rDNA in mitotic budding yeast cells...
  6. Johzuka K, Horiuchi T. The cis element and factors required for condensin recruitment to chromosomes. Mol Cell. 2009;34:26-35 pubmed publisher
    ..Our study also suggests that recruitment of condensin onto chromosomes requires cis elements and recruiters that physically interact with condensin. ..
  7. Butylin P, Strunnikov A. [Functional characteristics of the individual genomic condensin binding sites of Saccharomyces cerevisiae using minichromosome mitotic segregation stability model]. Tsitologiia. 2008;50:788-93 pubmed
    ..This approach allowed us to find out what was the individual contribution of condensin binding sites in securing mitotic stability of the minichromosomes. ..
  8. Lavoie B, Hogan E, Koshland D. In vivo dissection of the chromosome condensation machinery: reversibility of condensation distinguishes contributions of condensin and cohesin. J Cell Biol. 2002;156:805-15 pubmed
    ..Finally, we provide the first evidence of a mechanistic link between condensin and cohesin function. A model discussing the functional interplay between cohesin and condensin is presented. ..
  9. Charbin A, Bouchoux C, Uhlmann F. Condensin aids sister chromatid decatenation by topoisomerase II. Nucleic Acids Res. 2014;42:340-8 pubmed publisher
    ..Our results provide evidence that condensin prevents deleterious anaphase bridges during chromosome segregation by promoting sister chromatid decatenation. ..
  10. Laflamme G, Tremblay Boudreault T, Roy M, Andersen P, Bonneil E, Atchia K, et al. Structural maintenance of chromosome (SMC) proteins link microtubule stability to genome integrity. J Biol Chem. 2014;289:27418-31 pubmed publisher
    ..Collectively, these findings demonstrate that SMC proteins can bind to and stabilize microtubules and that SMC-microtubule interactions are essential to establish a robust system to maintain genome integrity. ..