Genomes and Genes
Gene Symbol: BI4
Description: intron-encoded RNA maturase bI4
Alias: intron-encoded RNA maturase bI4
Species: Saccharomyces cerevisiae S288c
- Rho S, Lincecum T, Martinis S. An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing. EMBO J. 2002;21:6874-81 pubmedYeast mitochondrial leucyl-tRNA synthetase (LeuRS) binds to the bI4 intron and collaborates with the bI4 maturase to aid excision of the group I intron...
- Goguel V, Perea J, Jacq C. Synthesis and function of the mitochondrial intron--encoded bI4 RNA maturase from Saccharomyces cerevisiae. Effects of upstream frame-shift mutations. Curr Genet. 1989;16:241-6 pubmedWe have analyzed the expression and function of the intron-encoded bI4 maturase when frame-shift mutations in the upstream exon alter the translational process...
- Labouesse M, Netter P, Schroeder R. Molecular basis of the 'box effect', A maturase deficiency leading to the absence of splicing of two introns located in two split genes of yeast mitochondrial DNA. Eur J Biochem. 1984;144:85-93 pubmed..to excise the fourth intron of oxi3 from the cytochrome oxidase subunit I pre-mRNA; the absence of a functional bI4 mRNA maturase, a trans-acting factor encoded by the fourth intron of the cob-box gene explains this phenomenon...
- Boniecki M, Rho S, Tukalo M, Hsu J, Romero E, Martinis S. Leucyl-tRNA synthetase-dependent and -independent activation of a group I intron. J Biol Chem. 2009;284:26243-50 pubmed publisher..Intracellular experiments have suggested that it works in collaboration with a maturase that is encoded within the bI4 intron...