Gene Symbol: BCK2
Description: Bck2p
Alias: CTR7, Bck2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Lee K, Hines L, Levin D. A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway. Mol Cell Biol. 1993;13:5843-53 pubmed
    ..The other suppressor gene, designated BCK2 (for bypass of C kinase), is predicted to encode a 92-kDa protein that is rich in serine and threonine residues...
  2. Di Como C, Chang H, Arndt K. Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2. Mol Cell Biol. 1995;15:1835-46 pubmed
    ..The members of one of these complementation groups have mutations in the BCK2 gene...
  3. Epstein C, Cross F. Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START. Mol Cell Biol. 1994;14:2041-7 pubmed
    ..at a low copy number; the gene responsible was distinct from BYC1 and was identical to the recently described BCK2 gene...
  4. Wijnen H, Futcher B. Genetic analysis of the shared role of CLN3 and BCK2 at the G(1)-S transition in Saccharomyces cerevisiae. Genetics. 1999;153:1131-43 pubmed
    ..Activation of SBF and MBF depends on the G(1) cyclin Cln3 and a largely uncharacterized protein called Bck2. We show here that the induction of SBF/MBF target genes by Bck2 depends partly, but not wholly, on SBF and MBF...
  5. Kuravi V, Kurischko C, Puri M, Luca F. Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock. Mol Biol Cell. 2011;22:4892-907 pubmed publisher
    ..Here we establish that Cbk1 is critical for heat shock and cell wall stress signaling via Bck2, a protein associated with the Pkc1-Mpk1 cell integrity pathway...
  6. Ferrezuelo F, Aldea M, Futcher B. Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast. Cell Cycle. 2009;8:239-52 pubmed
    ..b>Bck2 becomes essential in the absence of Cln3, the most upstream activator of this transcriptional program...
  7. Martin Yken H, Dagkessamanskaia A, Talibi D, Francois J. KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2, a gene involved in cell cycle progression in Saccharomyces cerevisiae. Curr Genet. 2002;41:323-32 pubmed
    ..The evidence that KNR4 is a member of the PKC1 pathway and genetically interacts with BCK2, a gene involved together with Cln3-Cdc28 in the G1 to S transition phase of the cell cycle, was as follows...
  8. Munoz I, Simon E, Casals N, Clotet J, Arino J. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast. 2003;20:157-69 pubmed
    ..The screening yielded several genes known to perform key roles in cell cycle events, such as CLN3, BCK2 or SWI4, thus proving its usefulness as a tool for this type of studies...
  9. Costanzo M, Schub O, Andrews B. G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1. Mol Cell Biol. 2003;23:5064-77 pubmed
    ..Chromatin immunoprecipitation experiments confirm that Stb1 localizes to promoters of MBF-regulated genes. Our data indicate that, contrary to previous models, MBF and SBF have unique components and might be distinctly regulated. ..

More Information


  1. Costanzo M, Nishikawa J, Tang X, Millman J, Schub O, Breitkreuz K, et al. CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Cell. 2004;117:899-913 pubmed
    ..Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription. These findings harmonize G1/S control in eukaryotes. ..
  2. de Bruin R, McDonald W, Kalashnikova T, Yates J, Wittenberg C. Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5. Cell. 2004;117:887-98 pubmed
    ..Like mammalian Rb, Whi5 is a G1-specific transcriptional repressor antagonized by CDK. ..
  3. Pathak R, Bogomolnaya L, Guo J, Polymenis M. Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:1627-38 pubmed
    ..Our findings identify two gene products with a probable regulatory role in the timing of initiation of cell division. ..
  4. Valachovic M, Bareither B, Shah Alam Bhuiyan M, Eckstein J, Barbuch R, Balderes D, et al. Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles. Genetics. 2006;173:1893-908 pubmed
    ..We show that deletion of YND1, like deletion of GDA1, alters the sphingolipid profiles, suggesting that changes in sphingolipids compensate for lethality produced by changes in sterol composition and abundance. ..
  5. Robinson K, Koepke J, Kharodawala M, Lopes J. A network of yeast basic helix-loop-helix interactions. Nucleic Acids Res. 2000;28:4460-6 pubmed
    ..Screening a yeast cDNA library identified three additional proteins that interact with Ino4p: Bck2p, YLR422W and YNR064C...
  6. Wang H, Carey L, Cai Y, Wijnen H, Futcher B. Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets. PLoS Biol. 2009;7:e1000189 pubmed publisher
    ..The cell may titrate Cln3 molecules against the number of SBF binding sites, and this could be the underlying basis of the size-control mechanism for Start. ..
  7. Martin Yken H, Dagkessamanskaia A, de Groot P, Ram A, Klis F, Francois J. Saccharomyces cerevisiae YCRO17c/CWH43 encodes a putative sensor/transporter protein upstream of the BCK2 branch of the PKC1-dependent cell wall integrity pathway. Yeast. 2001;18:827-40 pubmed
    ..Genetic analysis places CWH43 upstream of the BCK2 branch of the PKC1 signalling pathway, since cwh43 mutations were synthetic lethal with pkc1 deletion, whereas the ..
  8. Basmaji F, Martin Yken H, Durand F, Dagkessamanskaia A, Pichereaux C, Rossignol M, et al. The 'interactome' of the Knr4/Smi1, a protein implicated in coordinating cell wall synthesis with bud emergence in Saccharomyces cerevisiae. Mol Genet Genomics. 2006;275:217-30 pubmed
  9. Artiles K, Anastasia S, McCusker D, Kellogg D. The Rts1 regulatory subunit of protein phosphatase 2A is required for control of G1 cyclin transcription and nutrient modulation of cell size. PLoS Genet. 2009;5:e1000727 pubmed publisher
    ..Together, these observations demonstrate that Rts1 is a key player in pathways that link nutrient availability, cell size, and G1 cyclin transcription. Since Rts1 is highly conserved, it may function in similar pathways in vertebrates. ..
  10. Flick K, Wittenberg C. Multiple pathways for suppression of mutants affecting G1-specific transcription in Saccharomyces cerevisiae. Genetics. 2005;169:37-49 pubmed
    ..Together with additional characterization these findings indicate that multiple independent pathways are sufficient for proliferation in the absence of G(1)-specific transcriptional activators. ..
  11. Andrews P, Stark M. Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae. J Cell Sci. 2000;113 ( Pt 3):507-20 pubmed
    ..Dephosphorylation by PP1 therefore functions positively to promote cell integrity, bud morphology and polarization of the actin cytoskeleton and glc7-10 cells require higher levels of Pkc1p activity to sustain these functions. ..
  12. Bastajian N, Friesen H, Andrews B. Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast. PLoS Genet. 2013;9:e1003507 pubmed publisher
    The Bck2 protein is a potent genetic regulator of cell-cycle-dependent gene expression in budding yeast...
  13. Adames N, Schuck P, Chen K, Murali T, Tyson J, Peccoud J. Experimental testing of a new integrated model of the budding yeast Start transition. Mol Biol Cell. 2015;26:3966-84 pubmed publisher
    ..Our study demonstrates the advantages of combining model design, simulation, and testing in a coordinated effort to better understand a complex biological network. ..