Gene Symbol: BAS1
Description: Bas1p
Alias: Bas1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Pinson B, Vaur S, Sagot I, Coulpier F, Lemoine S, Daignan Fornier B. Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways. Genes Dev. 2009;23:1399-407 pubmed publisher
    ..AICAR binds both Pho2p and Pho4p transcription factors and stimulates the interaction between Pho2p and either Bas1p or Pho4p in vivo...
  2. Daignan Fornier B, Fink G. Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2. Proc Natl Acad Sci U S A. 1992;89:6746-50 pubmed
    We have found cross-pathway regulation between purine and histidine biosynthesis in yeast. The transcription factors BAS1 and BAS2/PHO2, which are also regulators of the histidine pathway, participate in the regulation of the purine ..
  3. Zhu X, Keeney S. High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions in Saccharomyces cerevisiae. Genetics. 2015;201:525-42 pubmed publisher
    ..Here, we examine at high resolution the contributions of two TFs to genome-wide DSB distributions: Bas1, which was known to regulate DSB activity at some loci, and Ino4, for which some binding sites were known to be ..
  4. Arndt K, Styles C, Fink G. Multiple global regulators control HIS4 transcription in yeast. Science. 1987;237:874-80 pubmed
    ..The basal level transcription of the HIS4 gene is under the control of two genes, BAS1 and BAS2, which are also required for the control of purine biosynthesis...
  5. Saint Marc C, Hürlimann H, Daignan Fornier B, Pinson B. Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae. Curr Genet. 2015;61:633-40 pubmed publisher
    ..In addition, we uncovered a new methionine auxotrophy for the ade3 bas1 double mutant that can be rescued by overexpressing the SHM2 gene...
  6. Martinez J, Bordel S, Hong K, Nielsen J. Gcn4p and the Crabtree effect of yeast: drawing the causal model of the Crabtree effect in Saccharomyces cerevisiae and explaining evolutionary trade-offs of adaptation to galactose through systems biology. FEMS Yeast Res. 2014;14:654-62 pubmed publisher
    ..cerevisiae strains growing on galactose and glucose, it was inferred that the transcription factors Bas1p, Pho2p, and Gcn4p play a central role in the regulatory events causing the Crabtree effect in S. cerevisiae...
  7. Servant G, Pinson B, Tchalikian Cosson A, Coulpier F, Lemoine S, Pennetier C, et al. Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress. Nucleic Acids Res. 2012;40:5271-82 pubmed publisher
  8. Rebora K, Desmoucelles C, Borne F, Pinson B, Daignan Fornier B. Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate. Mol Cell Biol. 2001;21:7901-12 pubmed
    ..AMP biosynthesis genes (ADE genes) are transcriptionally activated in the absence of extracellular purines by the Bas1p and Bas2p (Pho2p) transcription factors...
  9. Rossmann M, Luo W, Tsaponina O, Chabes A, Stillman B. A common telomeric gene silencing assay is affected by nucleotide metabolism. Mol Cell. 2011;42:127-36 pubmed publisher
    ..We conclude that metabolic changes caused by the drug employed and certain mutants being studied are incompatible with the use of certain prototrophic markers for TPEV. ..

More Information


  1. Mieczkowski P, Dominska M, Buck M, Gerton J, Lieb J, Petes T. Global analysis of the relationship between the binding of the Bas1p transcription factor and meiosis-specific double-strand DNA breaks in Saccharomyces cerevisiae. Mol Cell Biol. 2006;26:1014-27 pubmed
    ..The hot spot activity associated with the HIS4 gene requires the Bas1p transcription factor...
  2. Som I, Mitsch R, Urbanowski J, Rolfes R. DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces cerevisiae. Eukaryot Cell. 2005;4:1725-35 pubmed
    ..Derepression requires the transcriptional activators Bas1 and Pho2, as well as the biosynthetic intermediates 5'-phosphoribosyl-4-succinocarboxamide-5-aminoimidazole (SAICAR)..
  3. Joo Y, Kim J, Baek J, Seong K, Han K, Song J, et al. Cooperative regulation of ADE3 transcription by Gcn4p and Bas1p in Saccharomyces cerevisiae. Eukaryot Cell. 2009;8:1268-77 pubmed publisher
    ..Through gene deletion studies of Gcn4p and Bas1p, it was established that both factors are involved in the transcriptional regulation of the ADE3 gene...
  4. Subramanian M, Qiao W, Khanam N, Wilkins O, Der S, Lalich J, et al. Transcriptional regulation of the one-carbon metabolism regulon in Saccharomyces cerevisiae by Bas1p. Mol Microbiol. 2005;57:53-69 pubmed
    ..genes identified a conserved sequence, TGACTC, a known binding site for the transcription factors Gcn4p and Bas1p. Loss of BAS1 abolished or significantly reduced the repression of these genes in response to glycine removal but ..
  5. Hannum C, Kulaeva O, Sun H, Urbanowski J, Wendus A, Stillman D, et al. Functional mapping of Bas2. Identification of activation and Bas1-interaction domains. J Biol Chem. 2002;277:34003-9 pubmed
    ..and histidine biosynthesis, phosphate utilization, and the HO endonuclease by acting with co-regulator proteins Bas1, Pho4, and Swi5...
  6. Tsoi B, Beckhouse A, Gelling C, Raftery M, Chiu J, Tsoi A, et al. Essential role of one-carbon metabolism and Gcn4p and Bas1p transcriptional regulators during adaptation to anaerobic growth of Saccharomyces cerevisiae. J Biol Chem. 2009;284:11205-15 pubmed publisher
    ..In addition, the one-carbon metabolism and purine biosynthesis transcriptional regulator Bas1p were strictly required for anaerobic growth on minimal medium, and this was similarly due to l-serine limitation ..
  7. Pinson B, Kongsrud T, Ording E, Johansen L, Daignan Fornier B, Gabrielsen O. Signaling through regulated transcription factor interaction: mapping of a regulatory interaction domain in the Myb-related Bas1p. Nucleic Acids Res. 2000;28:4665-73 pubmed
    ..An example where this cooperation seems to be directly exploited for regulation is the Bas1p/Bas2p couple in yeast...
  8. Pinson B, Gabrielsen O, Daignan Fornier B. Redox regulation of AMP synthesis in yeast: a role of the Bas1p and Bas2p transcription factors. Mol Microbiol. 2000;36:1460-9 pubmed
    ..To get an insight into the molecular mechanisms of this new transcriptional regulation, the role of the Bas1p and Bas2p transcription factors, known to activate expression of the ADE genes, was investigated...
  9. Pinson B, Sagot I, Borne F, Gabrielsen O, Daignan Fornier B. Mutations in the yeast Myb-like protein Bas1p resulting in discrimination between promoters in vivo but notin vitro. Nucleic Acids Res. 1998;26:3977-85 pubmed
    b>Bas1p is a yeast transcription factor that activates expression of purine and histidine biosynthesis genes in response to extracellular purine limitation...
  10. Tice Baldwin K, Fink G, Arndt K. BAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2. Science. 1989;246:931-5 pubmed
    The BAS1 and BAS2 proteins are both required for activation of GCN4-independent (basal) HIS4 transcription in yeast. BAS1 has an NH2-terminal region similar to those of the myb proto-oncogene family...