Atm1p

Summary

Gene Symbol: Atm1p
Description: ATP-binding cassette Fe/S cluster precursor transporter ATM1
Alias: ATP-binding cassette Fe/S cluster precursor transporter ATM1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Kispal G, Csere P, Guiard B, Lill R. The ABC transporter Atm1p is required for mitochondrial iron homeostasis. FEBS Lett. 1997;418:346-50 pubmed
    The function of the ABC transporter Atm1p located in the mitochondrial inner membrane is not yet known. To study its cellular role, we analyzed a mutant in which ATM1 was disrupted...
  2. Kuhnke G, Neumann K, Muhlenhoff U, Lill R. Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds. Mol Membr Biol. 2006;23:173-84 pubmed
    The ATP binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs crucial roles in both the biogenesis of cytosolic/nuclear iron-sulfur proteins and cellular iron homeostasis...
  3. Kispal G, Csere P, Prohl C, Lill R. The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J. 1999;18:3981-9 pubmed
    ..The ATP-binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs an essential function only in the generation of cytosolic Fe/S ..
  4. Sipos K, Lange H, Fekete Z, Ullmann P, Lill R, Kispal G. Maturation of cytosolic iron-sulfur proteins requires glutathione. J Biol Chem. 2002;277:26944-9 pubmed
    ..Together, our data demonstrate that glutathione, in addition to its protective role against oxidative damage, performs a novel and specific function in the maturation of cytosolic Fe/S proteins. ..
  5. Leighton J, Schatz G. An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J. 1995;14:188-95 pubmed
    ..This gene, termed ATM1, encodes a putative 'half-transporter' of 694 amino acids. Atm1p is synthesized with an N-terminal mitochondrial matrix-targeting signal and is located in the mitochondrial inner ..
  6. Srinivasan V, Pierik A, Lill R. Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science. 2014;343:1137-40 pubmed publisher
    ..The resulting protein stabilization may be a common structural feature of all ABC exporters. ..
  7. Cheng Y, Chen R. Assembly and quality control of the protein phosphatase 1 holoenzyme involves the Cdc48-Shp1 chaperone. J Cell Sci. 2015;128:1180-92 pubmed publisher
    ..Our data suggest that Cdc48-Shp1 functions as a molecular chaperone for the structural integrity of PP1 complex in general and that it specifically promotes the assembly of Glc7-Sds22-Ypi1 for nuclear import. ..
  8. Chloupkova M, Reaves S, LeBard L, Koeller D. The mitochondrial ABC transporter Atm1p functions as a homodimer. FEBS Lett. 2004;569:65-9 pubmed
    ..In this study, we have evaluated the role of conserved sequence elements in Atm1p in its function and dimerization in vivo...
  9. Miao R, Kim H, Koppolu U, Ellis E, Scott R, Lindahl P. Biophysical characterization of the iron in mitochondria from Atm1p-depleted Saccharomyces cerevisiae. Biochemistry. 2009;48:9556-68 pubmed publisher
    b>Atm1p is an ABC transporter localized in the mitochondrial inner membrane; it functions to export an unknown species into the cytosol and is involved in cellular iron metabolism...

More Information

Publications13

  1. Schaedler T, Thornton J, Kruse I, Schwarzlander M, Meyer A, van Veen H, et al. A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly. J Biol Chem. 2014;289:23264-74 pubmed publisher
    ..We propose that mitochondria export glutathione polysulfide, containing glutathione and persulfide, for iron-sulfur cluster assembly in the cytosol. ..
  2. Chen C, Cowan J. Characterization of Saccharomyces cerevisiae Atm1p: functional studies of an ABC7 type transporter. Biochim Biophys Acta. 2006;1760:1857-65 pubmed
    Saccharomyces cerevisiae Atm1p has been cloned, over-expressed and purified from a yeast expression system. The sequence includes both the soluble ATPase and transmembrane-spanning domains...
  3. Zhang Y, Lyver E, Nakamaru Ogiso E, Yoon H, Amutha B, Lee D, et al. Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis. Mol Cell Biol. 2008;28:5569-82 pubmed publisher
  4. Chloupkova M, LeBard L, Koeller D. MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress. J Mol Biol. 2003;331:155-65 pubmed
    ..b>Atm1p is an ATP-binding cassette (ABC) transporter localized to the mitochondrial inner membrane...