Gene Symbol: ATF1
Description: alcohol O-acetyltransferase
Alias: alcohol O-acetyltransferase
Species: Saccharomyces cerevisiae S288c
Products:     ATF1

Top Publications

  1. Lilly M, Lambrechts M, Pretorius I. Effect of increased yeast alcohol acetyltransferase activity on flavor profiles of wine and distillates. Appl Environ Microbiol. 2000;66:744-53 pubmed
    ..blanc wines and distillates from Colombar base wines, we have overexpressed the alcohol acetyltransferase gene (ATF1) of S. cerevisiae...
  2. Mason A, Dufour J. Alcohol acetyltransferases and the significance of ester synthesis in yeast. Yeast. 2000;16:1287-98 pubmed
    ..In particular, control mechanisms that underpin the oxygen-mediated regulation of ATF1 gene transcription appear to be closely linked to those involved in the regulation of fatty acid metabolism...
  3. Verstrepen K, Van Laere S, Vercammen J, Derdelinckx G, Dufour J, Pretorius I, et al. The Saccharomyces cerevisiae alcohol acetyl transferase Atf1p is localized in lipid particles. Yeast. 2004;21:367-77 pubmed
    ..reveal the subcellular localization of Atf1p and further unravel the possible physiological role of this protein, ATF1::GFP fusion constructs were overexpressed in brewer's yeast...
  4. Ano A, Suehiro D, Cha aim K, Aritomi K, Phonimdaeng P, Nontaso N, et al. Combinatorial gene overexpression and recessive mutant gene introduction in sake yeast. Biosci Biotechnol Biochem. 2009;73:633-40 pubmed
    ..Moreover, none of these sake strains had extraneous sequences, and they are thus suitable for use in commercial applications. ..
  5. Ayer A, Tan S, Grant C, Meyer A, Dawes I, Perrone G. The critical role of glutathione in maintenance of the mitochondrial genome. Free Radic Biol Med. 2010;49:1956-68 pubmed publisher
    ..GSH may also modulate the redox environment of the IMS. The implications of altered GSH homeostasis for maintenance of mtDNA, compartmental redox, and the pathophysiology of certain diseases are discussed. ..
  6. Steyer D, Erny C, Claudel P, Riveill G, Karst F, Legras J. Genetic analysis of geraniol metabolism during fermentation. Food Microbiol. 2013;33:228-34 pubmed publisher
    ..We demonstrated both by gene overexpression and gene-deletion the involvement of ATF1 enzyme but not ATF2 in the acetylation of terpenols...
  7. Christiaens J, Franco L, Cools T, De Meester L, Michiels J, Wenseleers T, et al. The fungal aroma gene ATF1 promotes dispersal of yeast cells through insect vectors. Cell Rep. 2014;9:425-32 pubmed publisher
    ..including isoamyl acetate and ethyl acetate, are produced by a dedicated enzyme, the alcohol acetyl transferase Atf1. However, despite much research, the physiological role of acetate ester formation in yeast remains unknown...
  8. Zhao J, Li C, Zhang Y, Shen Y, Hou J, Bao X. Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae. Microb Cell Fact. 2017;16:17 pubmed publisher
    ..The deletion of OYE2 (encoding an NADPH oxidoreductase) or ATF1 (encoding an alcohol acetyltransferase) both involving endogenous conversion of geraniol to other terpenoids, ..
  9. Fujii T, Nagasawa N, Iwamatsu A, Bogaki T, Tamai Y, Hamachi M. Molecular cloning, sequence analysis, and expression of the yeast alcohol acetyltransferase gene. Appl Environ Microbiol. 1994;60:2786-92 pubmed
    The ATF1 gene, which encodes alcohol acetyltransferase (AATase), was cloned from Saccharomyces cerevisiae and brewery lager yeast (Saccharomyces uvarum). The nucleotide sequence of the ATF1 gene isolated from S. cerevisiae was determined...

More Information


  1. Verstrepen K, Van Laere S, Vanderhaegen B, Derdelinckx G, Dufour J, Pretorius I, et al. Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters. Appl Environ Microbiol. 2003;69:5228-37 pubmed
    ..Analysis of the fermentation products confirmed that the expression levels of ATF1 and ATF2 greatly affect the production of ethyl acetate and isoamyl acetate...
  2. PĂ©rez Sampietro M, Serra Cardona A, Canadell D, Casas C, Arino J, Herrero E. The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system. Sci Rep. 2016;6:32836 pubmed publisher
    ..We propose that the absence of Aft2 leads to enhanced Pho90 function, involving both Spl2-dependent and independent events and resulting in selenite hyperaccumulation and toxicity. ..
  3. Li W, Wang J, Zhang C, Ma H, Xiao D. Regulation of Saccharomyces cerevisiae genetic engineering on the production of acetate esters and higher alcohols during Chinese Baijiu fermentation. J Ind Microbiol Biotechnol. 2017;44:949-960 pubmed publisher
    ..Various mutants have been constructed to investigate the interactions of ATF1 overexpression, IAH1 deletion, and BAT2 deletion on the production of acetate esters and higher alcohols...