Gene Symbol: ASI1
Description: putative ubiquitin-protein ligase ASI1
Species: Saccharomyces cerevisiae S288c
Forsberg H, Hammar M, Andreasson C, Moliner A, Ljungdahl P. Suppressors of ssy1 and ptr3 null mutations define novel amino acid sensor-independent genes in Saccharomyces cerevisiae. Genetics. 2001;158:973-88 pubmed
..Mutations in the class I genes (ASI1, ASI2, ASI3, TUP1, SSN6, ASI13) derepress the transcription of AAP genes...
Boban M, Zargari A, Andréasson C, Heessen S, Thyberg J, Ljungdahl P. Asi1 is an inner nuclear membrane protein that restricts promoter access of two latent transcription factors. J Cell Biol. 2006;173:695-707 pubmed
..In this study, we report that Asi1 is an integral component of the inner nuclear membrane that maintains the latent characteristics of unprocessed ..
Zargari A, Boban M, Heessen S, Andréasson C, Thyberg J, Ljungdahl P. Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function in concert to maintain the latent properties of transcription factors Stp1 and Stp2. J Biol Chem. 2007;282:594-605 pubmed
..We recently reported that the inner nuclear membrane protein Asi1 is required to prevent unprocessed forms of Stp1 and Stp2, which ectopically enter the nucleus, from binding SPS ..
Boban M, Ljungdahl P. Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae. Genetics. 2007;176:2087-97 pubmed
..Stp1 and Stp2 "leak" into the nucleus, and the concerted action of inner nuclear membrane proteins Asi1, Asi2, and Asi3 restricts their promoter access...
Omnus D, Ljungdahl P. Latency of transcription factor Stp1 depends on a modular regulatory motif that functions as cytoplasmic retention determinant and nuclear degron. Mol Biol Cell. 2014;25:3823-33 pubmed publisher
..However, Stp1 latency depends on three inner nuclear membrane proteins, Asi1, Asi2, and Asi3...
Khmelinskii A, Blaszczak E, Pantazopoulou M, Fischer B, Omnus D, Le Dez G, et al
. Protein quality control at the inner nuclear membrane. Nature. 2014;516:410-3 pubmed publisher
..at the INM in yeast (Saccharomyces cerevisiae) mediated by the Asi complex consisting of the RING domain proteins Asi1 and Asi3 (ref. 4)...
Foresti O, Rodríguez Vaello V, Funaya C, Carvalho P. Quality control of inner nuclear membrane proteins by the Asi complex. Science. 2014;346:751-5 pubmed publisher
..This branch involved the integral membrane proteins Asi1, Asi2, and Asi3, which assembled into an Asi complex...