Gene Symbol: ARO10
Description: phenylpyruvate decarboxylase ARO10
Alias: phenylpyruvate decarboxylase ARO10
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Dickinson J, Salgado L, Hewlins M. The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae. J Biol Chem. 2003;278:8028-34 pubmed
  2. Jensen O, Podtelejnikov A, Sagliocco F, Wilm M, Vorm O, Mortensen P, et al. Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc Natl Acad Sci U S A. 1996;93:14440-5 pubmed
    ..This study establishes that mass spectrometry provides the required throughput, the certainty of identification, and the general applicability to serve as the method of choice to connect genome and proteome. ..
  3. Dickinson J, Harrison S, Dickinson J, Hewlins M. An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae. J Biol Chem. 2000;275:10937-42 pubmed
  4. Perp├Ęte P, Duthoit O, De Maeyer S, Imray L, Lawton A, Stavropoulos K, et al. Methionine catabolism in Saccharomyces cerevisiae. FEMS Yeast Res. 2006;6:48-56 pubmed
    ..Hence, methionine catabolism is more complex and economical than the other amino acid catabolic pathways in yeast, which use the Ehrlich pathway and result solely in the formation of a fusel alcohol. ..
  5. Kneen M, Stan R, Yep A, Tyler R, Saehuan C, McLeish M. Characterization of a thiamin diphosphate-dependent phenylpyruvate decarboxylase from Saccharomyces cerevisiae. FEBS J. 2011;278:1842-53 pubmed publisher
    The product of the ARO10 gene from Saccharomyces cerevisiae was initially identified as a thiamine diphosphate-dependent phenylpyruvate decarboxylase with a broad substrate specificity...
  6. Lee K, Sung C, Kim B, Hahn J. Activation of Aro80 transcription factor by heat-induced aromatic amino acid influx in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2013;438:43-7 pubmed publisher
    In Saccharomyces cerevisiae, transcription of ARO9 and ARO10 genes, involved in the catabolism of aromatic amino acids, is activated by Aro80 transcription factor in response to aromatic amino acids...
  7. Vuralhan Z, Morais M, Tai S, Piper M, Pronk J. Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae. Appl Environ Microbiol. 2003;69:4534-41 pubmed genes encoding thiamine diphosphate-dependent decarboxylases that could encode this activity: YDR380w/ARO10, YDL080C/THI3, PDC1, PDC5, and PDC6...
  8. Yin S, Zhou H, Xiao X, Lang T, Liang J, Wang C. Improving 2-phenylethanol production via Ehrlich pathway using genetic engineered Saccharomyces cerevisiae strains. Curr Microbiol. 2015;70:762-7 pubmed publisher
    ..The gene ARO8 encoding transaminase and the gene ARO10 encoding decarboxylase in the Ehrlich pathway were expressed in Saccharomyces cerevisiae S288c...
  9. Yin S, Lang T, Xiao X, Liu L, Sun B, Wang C. Significant enhancement of methionol production by co-expression of the aminotransferase gene ARO8 and the decarboxylase gene ARO10 in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2015;362: pubmed publisher
    ..In this work, two aminotransferase genes ARO8 and ARO9 and one decarboxylase gene ARO10 were introduced into S. cerevisiae S288c, respectively, via an expression vector...

More Information


  1. Yu A, Pratomo Juwono N, Foo J, Leong S, Chang M. Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids. Metab Eng. 2016;34:36-43 pubmed publisher
    ..We envision that this strategy could also be applied to the production of other chemicals in S. cerevisiae and may be extended to other microbes for strain improvement. ..