Gene Symbol: ARG80
Description: Arg80p
Alias: ARGR1, Arg80p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Ricci A, Genereaux J, Brandl C. Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium. Mol Cell Biol. 2002;22:4033-42 pubmed
    ..This suggests that SAGA has a dual role at ARG1, acting to repress transcription in rich medium and activate transcription in minimal medium. ..
  2. Dubois E, Bercy J, Messenguy F. Characterization of two genes, ARGRI and ARGRIII required for specific regulation of arginine metabolism in yeast. Mol Gen Genet. 1987;207:142-8 pubmed
    ..The transcription of both genes is not affected by the presence of arginine in the growth medium. ..
  3. Stundon J, Zakian V. Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase. G3 (Bethesda). 2015;5:2913-8 pubmed publisher
    ..This study identified eleven genes that were synthetic lethal (APM1, ARG80, CDH1, GCR1, GTO3, PRK1, RAD10, SKT5, SOP4, UMP1, and YCK1) and three genes that were synthetic sick (DEF1, YIP4, ..
  4. Amar N, Messenguy F, El Bakkoury M, Dubois E. ArgRII, a component of the ArgR-Mcm1 complex involved in the control of arginine metabolism in Saccharomyces cerevisiae, is the sensor of arginine. Mol Cell Biol. 2000;20:2087-97 pubmed
  5. Messenguy F, Vierendeels F, Scherens B, Dubois E. In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex. J Bacteriol. 2000;182:3158-64 pubmed
    ..Our data also show that the deletion of the UME6 gene impairs cell growth more strongly than the deletion of the SIN3 or RPD3 gene, especially in the Sigma1278b background. ..
  6. Jamai A, Dubois E, Vershon A, Messenguy F. Swapping functional specificity of a MADS box protein: residues required for Arg80 regulation of arginine metabolism. Mol Cell Biol. 2002;22:5741-52 pubmed
    b>Arg80 and Mcm1, two members of the MADS box family of DNA-binding proteins, regulate the metabolism of arginine in association with Arg81, the arginine sensor...
  7. Bechet J, Greenson M, Wiame J. Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae. Eur J Biochem. 1970;12:31-9 pubmed
  8. Kovari L, Fourie M, Park H, Kovari I, van Vuuren H, Cooper T. Analysis of the inducer-responsive CAR1 upstream activation sequence (UASI) and the factors required for its operation. Yeast. 1993;9:835-45 pubmed
    ..of arginase (CAR1) enzyme activity and steady-state CAR1 mRNA in Saccharomyces cerevisiae requires wild-type ARG80/ARGRI and ARG81/ARGRII gene products...
  9. El Bakkoury M, Dubois E, Messenguy F. Recruitment of the yeast MADS-box proteins, ArgRI and Mcm1 by the pleiotropic factor ArgRIII is required for their stability. Mol Microbiol. 2000;35:15-31 pubmed
    ..However, ArgRIII is likely to recruit other proteins in the yeast cell, as overexpression of Mcm1 does not compensate some physiological defects observed in an argRIII deletant strain. ..

More Information


  1. El Alami M, Messenguy F, Scherens B, Dubois E. Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. Mol Microbiol. 2003;49:457-68 pubmed
    ..Arg82p also controls expression of arginine-responsive genes by interacting with Arg80p and Mcm1p, and expression of Mcm1-dependent genes by interacting with Mcm1p...
  2. Yoon S, Govind C, Qiu H, Kim S, Dong J, Hinnebusch A. Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism. Proc Natl Acad Sci U S A. 2004;101:11713-8 pubmed
    ..Mcm1p and Arg80p were found in a soluble complex lacking Arg81p and Arg82p, and both Mcm1p and Arg80p were efficiently recruited to ..
  3. Crisucci E, Arndt K. Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter. Mol Cell Biol. 2012;32:1150-63 pubmed publisher
    ..This promoter-associated antisense transcription positively correlates with ARG1 sense transcription. Finally, our results indicate that Paf1 represses other genes through mechanisms similar to those used at the ARG1 gene. ..
  4. Bercy J, Dubois E, Messenguy F. Regulation of arginine metabolism in Saccharomyces cerevisiae: expression of the three ARGR regulatory genes and cellular localization of their products. Gene. 1987;55:277-85 pubmed
    ..However, some data suggest that the ARGRIII protein could control ARGRI activity. ..