ARG5,6

Summary

Gene Symbol: ARG5,6
Description: bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
Alias: bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Boonchird C, Messenguy F, Dubois E. Characterization of the yeast ARG5,6 gene: determination of the nucleotide sequence, analysis of the control region and of ARG5,6 transcript. Mol Gen Genet. 1991;226:154-66 pubmed
    ..Specific regulation involves two regions: one located between the putative TATA element and the transcriptional initiation site and the second between this site and the first ATG. ..
  2. Pauwels K, Abadjieva A, Hilven P, Stankiewicz A, Crabeel M. The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis. Eur J Biochem. 2003;270:1014-24 pubmed
    ..We conclude that the NAGS/NAGK metabolon promotes the co-ordination of the catalytic activities and feedback regulation of the first two, flux controlling, enzymes of the arginine pathway. ..
  3. Hall D, Zhu H, Zhu X, Royce T, Gerstein M, Snyder M. Regulation of gene expression by a metabolic enzyme. Science. 2004;306:482-4 pubmed
    ..Deletion of Arg5,6 causes altered transcript levels of both nuclear and mitochondrial target genes. These results indicate that metabolic enzymes can directly regulate eukaryotic gene expression. ..
  4. Merhi A, GĂ©rard N, Lauwers E, Prevost M, Andre B. Systematic mutational analysis of the intracellular regions of yeast Gap1 permease. PLoS ONE. 2011;6:e18457 pubmed publisher
    ..Interestingly, this direct vacuolar sorting seems to be independent of Gap1 ubiquitylation. This study illustrates the importance of multiple intracellular regions of Gap1 in its secretion, transport activity, and down-regulation. ..