Gene Symbol: ARE2
Description: sterol acyltransferase
Alias: SAT1, sterol acyltransferase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Yang H, Bard M, Bruner D, Gleeson A, Deckelbaum R, Aljinovic G, et al. Sterol esterification in yeast: a two-gene process. Science. 1996;272:1353-6 pubmed
    ..Here, two genes are identified, ARE1 and ARE2, that encode ACAT-related enzymes in yeast...
  2. Zweytick D, Leitner E, Kohlwein S, Yu C, Rothblatt J, Daum G. Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem. 2000;267:1075-82 pubmed
    ..Deletion of either ARE1 or ARE2 has no effect on cell viability, and are1are2 double mutants grow in a similar manner to wild-type despite the ..
  3. Petschnigg J, Wolinski H, Kolb D, Zellnig G, Kurat C, Natter K, et al. Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast. J Biol Chem. 2009;284:30981-93 pubmed publisher
  4. Garbarino J, Padamsee M, Wilcox L, Oelkers P, D Ambrosio D, Ruggles K, et al. Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J Biol Chem. 2009;284:30994-1005 pubmed publisher
    ..In metazoans, many of these processes are implicated in insulin secretion thus linking lipotoxicity with early aspects of pancreatic beta-cell dysfunction, diabetes, and the metabolic syndrome. ..
  5. Tinkelenberg A, Liu Y, Alcantara F, Khan S, Guo Z, Bard M, et al. Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem. 2000;275:40667-70 pubmed
    ..The genes are predicted to encode transmembrane proteins with potential zinc-binding motifs. We propose that ARV1 is a novel mediator of eukaryotic sterol homeostasis. ..
  6. Adeyo O, Horn P, Lee S, Binns D, Chandrahas A, Chapman K, et al. The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets. J Cell Biol. 2011;192:1043-55 pubmed publisher
    ..Overall, this study provides strong evidence that DAG generated by Pah1p is important for droplet biogenesis. ..
  7. Voynova N, Vionnet C, Ejsing C, Conzelmann A. A novel pathway of ceramide metabolism in Saccharomyces cerevisiae. Biochem J. 2012;447:103-14 pubmed publisher
    ..Acylceramides are mobilized when cells are diluted into fresh medium in the presence of cerulenin, an inhibitor of fatty acid biosynthesis. ..
  8. Li D, Song J, Li H, Shan M, Liang Y, Zhu J, et al. Storage lipid synthesis is necessary for autophagy induced by nitrogen starvation. FEBS Lett. 2015;589:269-76 pubmed publisher
    ..Finally, we demonstrate that lipid droplets transiently interact with Atg8-containing membranes. Our study reveals a novel connection linking neutral lipid metabolism, lipid droplets and autophagy. ..
  9. Barbosa A, Sembongi H, Su W, Abreu S, Reggiori F, Carman G, et al. Lipid partitioning at the nuclear envelope controls membrane biogenesis. Mol Biol Cell. 2015;26:3641-57 pubmed publisher
    ..We propose that, in response to growth signals, activation of Pah1 at the nuclear envelope acts as a switch to control the balance between membrane biogenesis and lipid storage. ..

More Information


  1. Klein I, Klug L, Schmidt C, Zandl M, Korber M, Daum G, et al. Regulation of the yeast triacylglycerol lipases Tgl4p and Tgl5p by the presence/absence of nonpolar lipids. Mol Biol Cell. 2016;27:2014-24 pubmed publisher
    ..These results suggest that Tgl3p, Tgl4p, and Tgl5p, although they exhibit similar functions, act as independent entities. ..
  2. Sandager L, Gustavsson M, Stahl U, Dahlqvist A, Wiberg E, Banas A, et al. Storage lipid synthesis is non-essential in yeast. J Biol Chem. 2002;277:6478-82 pubmed
    ..We have used single and multiple gene disruptions to study storage lipid synthesis in yeast. Four genes, ARE1, ARE2, DGA1, and LRO1, were found to contribute to TAG synthesis...
  3. Hodge C, Choudhary V, Wolyniak M, Scarcelli J, Schneiter R, Cole C. Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum. J Cell Sci. 2010;123:141-51 pubmed publisher
    ..These data indicate that Brr6 has an essential function in regulating lipid homeostasis in the NE-ER, thereby impacting NPC formation and nucleocytoplasmic transport. ..
  4. Foresti O, Ruggiano A, Hannibal Bach H, Ejsing C, Carvalho P. Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4. elife. 2013;2:e00953 pubmed publisher
    ..DOI: ..
  5. Gulati S, Balderes D, Kim C, Guo Z, Wilcox L, Area Gomez E, et al. ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification. FASEB J. 2015;29:4682-94 pubmed publisher
  6. Lone M, Atkinson A, Hodge C, Cottier S, Martínez Montañés F, Maithel S, et al. Yeast Integral Membrane Proteins Apq12, Brl1, and Brr6 Form a Complex Important for Regulation of Membrane Homeostasis and Nuclear Pore Complex Biogenesis. Eukaryot Cell. 2015;14:1217-27 pubmed publisher
    ..We suggest that the defects in nuclear pore complex biogenesis and mRNA export seen in these mutants are consequences of defects in maintaining the biophysical properties of the NE. ..
  7. Jacquier N, Choudhary V, Mari M, Toulmay A, Reggiori F, Schneiter R. Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Sci. 2011;124:2424-37 pubmed publisher
    ..These observations indicate that LDs are functionally connected to the ER membrane and that this connection allows the efficient partitioning of membrane proteins between the two compartments. ..