Gene Symbol: ARA1
Description: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1
Alias: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1
Species: Saccharomyces cerevisiae S288c
Kim S, Huh W, Lee B, Kang S. D-arabinose dehydrogenase and its gene from Saccharomyces cerevisiae. Biochim Biophys Acta. 1998;1429:29-39 pubmed
..This enzyme is the first heterodimeric protein of aldo-keto reductase family. In the deletion mutant of this gene, D-arabinose dehydrogenase activity and D-erythroascorbic acid were not detected. ..
Petrash J, Murthy B, Young M, Morris K, Rikimaru L, Griest T, et al
. Functional genomic studies of aldo-keto reductases. Chem Biol Interact. 2001;130-132:673-83 pubmed
..Ongoing studies are aimed at characterizing the phenotypes of yeast strains containing single and multiple knockouts of the AR-like genes. ..
Izawa S, Sato M, Yokoigawa K, Inoue Y. Intracellular glycerol influences resistance to freeze stress in Saccharomyces cerevisiae: analysis of a quadruple mutant in glycerol dehydrogenase genes and glycerol-enriched cells. Appl Microbiol Biotechnol. 2004;66:108-14 pubmed
..Through analysis of a quadruple-knockout mutant of glycerol dehydrogenase genes (ara1 Delta gcy1 Delta gre3 Delta ypr1 Delta) in Saccharomyces cerevisiae, we revealed that the decrease in glycerol ..
van Bergen B, Strasser R, Cyr N, Sheppard J, Jardim A. Alpha,beta-dicarbonyl reduction by Saccharomyces D-arabinose dehydrogenase. Biochim Biophys Acta. 2006;1760:1636-45 pubmed
..was purified from Saccharomyces cerevisiae and identified as the cytosolic enzyme D-Arabinose dehydrogenase (ARA1) by MALDI-TOF/TOF...
Amako K, Fujita K, Shimohata T, Hasegawa E, Kishimoto R, Goda K. NAD+-specific D-arabinose dehydrogenase and its contribution to erythroascorbic acid production in Saccharomyces cerevisiae. FEBS Lett. 2006;580:6428-34 pubmed
..conspicuous increase in intracellular eAsA by exogenous d-arabinose feeding, while the double knockout mutant of ARA1 and ARA2 still retained measurable amount of eAsA...
Gonzalez E, Fernández M, Marco D, Calam E, Sumoy L, Parés X, et al
. Role of Saccharomyces cerevisiae oxidoreductases Bdh1p and Ara1p in the metabolism of acetoin and 2,3-butanediol. Appl Environ Microbiol. 2010;76:670-9 pubmed publisher
..Furthermore, we have expressed Bdh2p with a histidine tag and have shown it to be inactive toward 2,3-butanediol. A whole-genome expression analysis with microarrays demonstrates that BDH1 and BDH2 are reciprocally regulated. ..
Hu X, Guo P, Ma J, Li W. Structures of Saccharomyces cerevisiae D-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013;69:1190-5 pubmed publisher
The primary role of yeast Ara1, previously mis-annotated as a D-arabinose dehydrogenase, is to catalyze the reduction of a variety of toxic ?,?-dicarbonyl compounds using NADPH as a cofactor at physiological pH levels...