Gene Symbol: ALR1
Description: Mg(2+) transporter ALR1
Alias: SWC3, Mg(2+) transporter ALR1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. MacDiarmid C, Gardner R. Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. J Biol Chem. 1998;273:1727-32 pubmed
    ..We describe the isolation of two yeast genes (ALR1 and ALR2) which confer increased tolerance to Al3+ and Ga3+ ions when overexpressed while increasing strain ..
  2. Wachek M, Aichinger M, Stadler J, Schweyen R, Graschopf A. Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane. FEBS J. 2006;273:4236-49 pubmed
    ..Homologs of Alr1p are restricted to fungi and some protozoa. Alr1-type proteins are distant relatives of the mitochondrial and bacterial Mg(2+)-transport proteins, Mrs2p and CorA, ..
  3. Pisat N, Pandey A, MacDiarmid C. MNR2 regulates intracellular magnesium storage in Saccharomyces cerevisiae. Genetics. 2009;183:873-84 pubmed publisher
    ..genome encodes four characterized members of the CorA Mg transporter superfamily located in the plasma membrane (Alr1 and Alr2) or the mitochondrial inner membrane (Mrs2 and Lpe10)...
  4. Lee J, Gardner R. Residues of the yeast ALR1 protein that are critical for magnesium uptake. Curr Genet. 2006;49:7-20 pubmed
    Mutagenesis was used to study the function by the ALR1 (aluminium resistance) gene, which encodes the major Mg(2+) uptake system in yeast...
  5. Johansson M, Jacobson A. Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake. Genes Dev. 2010;24:1491-5 pubmed publisher
    ..Alr1p levels increase because an upstream ORF in ALR1 mRNA targets the transcript for NMD...
  6. Tran H, Steger D, Iyer V, Johnson A. The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor. EMBO J. 2000;19:2323-31 pubmed
    ..Taken together, these results suggest that Chd1p functions as a nucleosome remodeling factor, and that Chd1p may share overlapping roles with the SWI-SNF complex to regulate transcription. ..
  7. Gregan J, Kolisek M, Schweyen R. Mitochondrial Mg(2+) homeostasis is critical for group II intron splicing in vivo. Genes Dev. 2001;15:2229-37 pubmed
    ..It explains finally why protein factors modulating Mg(2+) homeostasis had been identified in genetic screens for bona fide RNA splicing factors. ..
  8. da Costa B, Cornish K, Keasling J. Manipulation of intracellular magnesium levels in Saccharomyces cerevisiae with deletion of magnesium transporters. Appl Microbiol Biotechnol. 2007;77:411-25 pubmed
    ..It is known that Saccharomyces cerevisiae has two magnesium transporters (ALR1 and ALR2) across the plasma membrane. We created S...
  9. Lim P, Pisat N, Gadhia N, Pandey A, Donovan F, Stein L, et al. Regulation of Alr1 Mg transporter activity by intracellular magnesium. PLoS ONE. 2011;6:e20896 pubmed publisher
    ..In yeast, Mg uptake is primarily mediated by the Alr1 transporter, which also allows low affinity uptake of other divalent cations such as Ni(2+), Mn(2+), Zn(2+) and Co(..

More Information


  1. Daithankar V, Wang W, Trujillo J, Thorpe C. Flavin-linked Erv-family sulfhydryl oxidases release superoxide anion during catalytic turnover. Biochemistry. 2012;51:265-72 pubmed publisher
    ..Aspects of the mechanism and possible physiological significance of superoxide release from these Erv-domain flavoproteins are discussed. ..
  2. Liu G, Martin D, Gardner R, Ryan P. Large Mg(2+)-dependent currents are associated with the increased expression of ALR1 in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2002;213:231-7 pubmed
    Two genes in Saccharomyces cerevisiae, ALR1 and ALR2, encode proteins putatively involved in Mg(2+) uptake. The present study supports this role for ALR1 and provides the first electrophysiological characterisation of this protein...
  3. Brandina I, Smirnov A, Kolesnikova O, Entelis N, Krasheninnikov I, Martin R, et al. tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system. FEBS Lett. 2007;581:4248-54 pubmed
    ..This result suggests a functional link between UPS and tRNA mitochondrial import in yeast and indicates on the existence of negative and positive import regulators. ..