ALE1

Summary

Gene Symbol: ALE1
Description: Ale1p
Alias: LCA1, LPT1, SLC4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast
    Mohammed Benghezal
    Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Biol Chem 282:30845-55. 2007
  2. ncbi Identification and characterization of the major lysophosphatidylethanolamine acyltransferase in Saccharomyces cerevisiae
    Wayne R Riekhof
    Department of Medicine, Program in Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 282:28344-52. 2007
  3. ncbi Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae
    Shilpa Jain
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:30562-9. 2007
  4. ncbi LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae
    Hisanori Tamaki
    Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima, Japan
    J Biol Chem 282:34288-98. 2007
  5. ncbi Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: the role of P-type ATPases in transport and a broad specificity acyltransferase in acylation
    Wayne R Riekhof
    Department of Medicine, Program in Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 282:36853-61. 2007
  6. ncbi The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover
    Qilin Chen
    Plant Biotechnology Institute, National Research Council Canada, 110 Gymnasium Place, Saskatoon, SK, Canada
    FEBS Lett 581:5511-6. 2007
  7. doi Phosphatidylethanolamine synthesized by four different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae
    Irmgard Schuiki
    Institute of Biochemistry, Graz University of Technology, Petersgasse 12 2, A 8010 Graz, Austria
    Biochim Biophys Acta 1801:480-6. 2010
  8. pmc Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1
    Kailash Gulshan
    Department of Molecular Physiology and Biophysics, Carver College of Medicine, 6 530 Bowen Science Building, University of Iowa, Iowa City, IA 52246, USA
    Traffic 12:1257-68. 2011
  9. pmc Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae
    Martin Pagac
    Department of Biology, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Biol Chem 286:36438-47. 2011

Scientific Experts

  • Hisanori Tamaki
  • Wayne R Riekhof
  • Martin Pagac
  • Kailash Gulshan
  • Irmgard Schuiki
  • Carole Roubaty
  • Andreas Conzelmann
  • Dennis R Voelker
  • Qilin Chen
  • James Wu
  • Mohammed Benghezal
  • Shilpa Jain
  • Hector Vazquez de la Mora
  • Christine Vionnet
  • W Scott Moye-Rowley
  • Cécile Duperrex
  • Tibor Czabany
  • Claudia Hrastnik
  • Gunther Daum
  • Martina Schnabl
  • Robert C Murphy
  • Brian Seiler
  • Zhifu Zheng
  • Jens Knudsen
  • Vijayanath Veepuri
  • Simona Zarini
  • Jennifer L Jones
  • Michael Kazachkov
  • Charles Boone
  • Michael Costanzo
  • Jitao Zou
  • Miguel A Gijón
  • Neha Bhagwat
  • Peter Oelkers
  • NaTaza Stanford

Detail Information

Publications9

  1. ncbi SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast
    Mohammed Benghezal
    Department of Medicine, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Biol Chem 282:30845-55. 2007
    ..Here we show that SLC4 (Yor175c), a gene of hitherto unknown function, encodes a second 1-acyl-sn-glycerol-3-phosphate acyltransferase...
  2. ncbi Identification and characterization of the major lysophosphatidylethanolamine acyltransferase in Saccharomyces cerevisiae
    Wayne R Riekhof
    Department of Medicine, Program in Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 282:28344-52. 2007
    ..reading frame, YOR175C, encodes the major acyl-CoA-dependent LPEAT activity in yeast and henceforth refer to it as ALE1 (acyltransferase for lyso-PtdEtn)...
  3. ncbi Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae
    Shilpa Jain
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:30562-9. 2007
    ..One of the genes identified by the screen, LPT1, was found to encode for an acyltransferase that uses a variety of lysophospholipid species, including 1-acyl-sn-..
  4. ncbi LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae
    Hisanori Tamaki
    Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima, Japan
    J Biol Chem 282:34288-98. 2007
    ..has been predicted to be a member of the membrane-bound O-acyltransferase superfamily, and we designated the gene LPT1. An Lpt1-green fluorescent protein fusion protein localized at the endoplasmic reticulum...
  5. ncbi Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: the role of P-type ATPases in transport and a broad specificity acyltransferase in acylation
    Wayne R Riekhof
    Department of Medicine, Program in Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 282:36853-61. 2007
    ..These results establish a new pathway for the net synthesis of PtdCho in yeast and provide new tools for the study of PtdCho synthesis, transport, and remodeling...
  6. ncbi The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover
    Qilin Chen
    Plant Biotechnology Institute, National Research Council Canada, 110 Gymnasium Place, Saskatoon, SK, Canada
    FEBS Lett 581:5511-6. 2007
    ..In this report, we provide evidence demonstrating that yeast YOR175c, herein designated as LCA1, encodes a key component of the Lands cycle, the acyl-CoA: lysophosphatidylcholine acyltransferase (LPCAT)...
  7. doi Phosphatidylethanolamine synthesized by four different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae
    Irmgard Schuiki
    Institute of Biochemistry, Graz University of Technology, Petersgasse 12 2, A 8010 Graz, Austria
    Biochim Biophys Acta 1801:480-6. 2010
    ..In summary, the PE level in the plasma membrane is strongly influenced by total cellular PE synthesis, but fine tuned by selective assembly mechanisms...
  8. pmc Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1
    Kailash Gulshan
    Department of Molecular Physiology and Biophysics, Carver College of Medicine, 6 530 Bowen Science Building, University of Iowa, Iowa City, IA 52246, USA
    Traffic 12:1257-68. 2011
    ..Our data describe a novel vacuolar route for lipid remodeling and reutilization in addition to previously described enzymatic avenues in the cytoplasm...
  9. pmc Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae
    Martin Pagac
    Department of Biology, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Biol Chem 286:36438-47. 2011
    ..The implications of these findings are discussed...