ALA1

Summary

Gene Symbol: ALA1
Description: alanine--tRNA ligase
Alias: CDC64, alanine--tRNA ligase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Ripmaster T, Shiba K, Schimmel P. Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen. Proc Natl Acad Sci U S A. 1995;92:4932-6 pubmed
    ..U70 base pair. An ala1 disrupted allele demonstrated that the gene is essential and that, therefore, ALA1 encodes an enzyme required for ..
  2. Huang H, Tang H, Chao H, Yeh L, Wang C. An unusual pattern of protein expression and localization of yeast alanyl-tRNA synthetase isoforms. Mol Microbiol. 2006;60:189-98 pubmed
    ..cerevisiae the mitochondrial and cytoplasmic forms of alanyl-tRNA synthetase are encoded by a single nuclear gene, ALA1, through alternative use of in-frame successive ACG triplets and a downstream AUG triplet...
  3. Chang K, Lin G, Men L, Wang C. Redundancy of non-AUG initiators. A clever mechanism to enhance the efficiency of translation in yeast. J Biol Chem. 2006;281:7775-83 pubmed
    It was recently shown that ALA1, the only alanyl-tRNA synthetase gene in Saccharomyces cerevisiae, uses two successive ACG triplets as the translation initiators for its mitochondrial form...